Scarlett Lin Gomez1,2, Julie Von Behren3, Meg McKinley3, Christina A Clarke3,4, Salma Shariff-Marco3,4, Iona Cheng3,4, Peggy Reynolds3,4, Sally L Glaser3,4. 1. Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA, 94538, USA. scarlett@cpic.org. 2. Stanford Cancer Institute, Stanford, CA, USA. scarlett@cpic.org. 3. Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA, 94538, USA. 4. Stanford Cancer Institute, Stanford, CA, USA.
Abstract
PURPOSE: In contrast to other US racial/ethnic groups, Asian Americans (AA) have experienced steadily increasing breast cancer rates in recent decades. To better understand potential contributors to this increase, we examined incidence trends by age and stage among women from seven AA ethnic groups in California from 1988 to 2013, and incidence patterns by subtype and age at diagnosis for the years 2009 through 2013. METHODS: Joinpoint regression was applied to California Cancer Registry data to calculate annual percentage change (APC) for incidence trends. Incidence rate ratios were used to compare rates for AA ethnic groups relative to non-Hispanic whites (NHW). RESULTS: All AA groups except Japanese experienced incidence increases, with the largest among Koreans in 1988-2006 (APC 4.7, 95% CI 3.8, 5.7) and Southeast Asians in 1988-2013 (APC 2.5, 95% CI 0.8, 4.2). Among women younger than age 50, large increases occurred for Vietnamese and other Southeast Asians; among women over age 50, increasing trends occurred in all AA ethnic groups. Rates increased for distant-stage disease among Filipinas (2.2% per year, 95% CI 0.4, 3.9). Compared to NHW, Filipinas and older Vietnamese had higher incidence rates of some HER2+ subtypes. CONCLUSIONS: Breast cancer incidence rates have risen rapidly among California AA, with the greatest increases in Koreans and Southeast Asians. Culturally tailored efforts to increase awareness of and attention to breast cancer risk factors are needed. Given the relatively higher rates of HER2-overexpressing subtypes in some AA ethnicities, research including these groups and their potentially unique exposures may help elucidate disease etiology.
PURPOSE: In contrast to other US racial/ethnic groups, Asian Americans (AA) have experienced steadily increasing breast cancer rates in recent decades. To better understand potential contributors to this increase, we examined incidence trends by age and stage among women from seven AA ethnic groups in California from 1988 to 2013, and incidence patterns by subtype and age at diagnosis for the years 2009 through 2013. METHODS: Joinpoint regression was applied to California Cancer Registry data to calculate annual percentage change (APC) for incidence trends. Incidence rate ratios were used to compare rates for AA ethnic groups relative to non-Hispanic whites (NHW). RESULTS: All AA groups except Japanese experienced incidence increases, with the largest among Koreans in 1988-2006 (APC 4.7, 95% CI 3.8, 5.7) and Southeast Asians in 1988-2013 (APC 2.5, 95% CI 0.8, 4.2). Among women younger than age 50, large increases occurred for Vietnamese and other Southeast Asians; among women over age 50, increasing trends occurred in all AA ethnic groups. Rates increased for distant-stage disease among Filipinas (2.2% per year, 95% CI 0.4, 3.9). Compared to NHW, Filipinas and older Vietnamese had higher incidence rates of some HER2+ subtypes. CONCLUSIONS: Breast cancer incidence rates have risen rapidly among California AA, with the greatest increases in Koreans and Southeast Asians. Culturally tailored efforts to increase awareness of and attention to breast cancer risk factors are needed. Given the relatively higher rates of HER2-overexpressing subtypes in some AA ethnicities, research including these groups and their potentially unique exposures may help elucidate disease etiology.
Entities:
Keywords:
Asian; Asian American; Breast cancer; HER2–Neu; Subtype; Trend
Authors: Carol E DeSantis; Stacey A Fedewa; Ann Goding Sauer; Joan L Kramer; Robert A Smith; Ahmedin Jemal Journal: CA Cancer J Clin Date: 2015-10-29 Impact factor: 508.702
Authors: Limin X Clegg; Marsha E Reichman; Benjamin F Hankey; Barry A Miller; Yi D Lin; Norman J Johnson; Stephen M Schwartz; Leslie Bernstein; Vivien W Chen; Marc T Goodman; Scarlett L Gomez; John J Graff; Charles F Lynch; Charles C Lin; Brenda K Edwards Journal: Cancer Causes Control Date: 2007-01-11 Impact factor: 2.506
Authors: Lu Chen; Christopher I Li; Mei-Tzu C Tang; Peggy Porter; Deirdre A Hill; Charles L Wiggins; Linda S Cook Journal: Cancer Epidemiol Biomarkers Prev Date: 2016-06-15 Impact factor: 4.254
Authors: Julia S Sisti; Laura C Collins; Andrew H Beck; Rulla M Tamimi; Bernard A Rosner; A Heather Eliassen Journal: Int J Cancer Date: 2016-02-08 Impact factor: 7.396
Authors: Scarlett Lin Gomez; Anne-Michelle Noone; Daphne Y Lichtensztajn; Steve Scoppa; James T Gibson; Lihua Liu; Cyllene Morris; Sandy Kwong; Kari Fish; Lynne R Wilkens; Marc T Goodman; Dennis Deapen; Barry A Miller Journal: J Natl Cancer Inst Date: 2013-07-22 Impact factor: 13.506
Authors: Joel S Parker; Michael Mullins; Maggie C U Cheang; Samuel Leung; David Voduc; Tammi Vickery; Sherri Davies; Christiane Fauron; Xiaping He; Zhiyuan Hu; John F Quackenbush; Inge J Stijleman; Juan Palazzo; J S Marron; Andrew B Nobel; Elaine Mardis; Torsten O Nielsen; Matthew J Ellis; Charles M Perou; Philip S Bernard Journal: J Clin Oncol Date: 2009-02-09 Impact factor: 44.544
Authors: Eunjung Lee; Namphuong Doanvo; MiHee Lee; Zayar Soe; Alice W Lee; Cam Van Doan; Dennis Deapen; Giske Ursin; Darcy Spicer; Peggy Reynolds; Anna H Wu Journal: Cancer Causes Control Date: 2020-01-08 Impact factor: 2.506
Authors: Meredith L Shoemaker; Mary C White; Manxia Wu; Hannah K Weir; Isabelle Romieu Journal: Breast Cancer Res Treat Date: 2018-02-14 Impact factor: 4.872
Authors: Esther M John; Lisa M Hines; Amanda I Phipps; Jocelyn Koo; Teri A Longacre; Sue A Ingles; Kathy B Baumgartner; Martha L Slattery; Anna H Wu Journal: Int J Cancer Date: 2018-01-30 Impact factor: 7.396