Literature DB >> 28361454

Self-Report and Dry Blood Spot Measurement of Antiretroviral Medications as Markers of Adherence in Pregnant Women in Rural South Africa.

Maria L Alcaide1, Shandir Ramlagan2, Violeta J Rodriguez3, Ryan Cook3,4, Karl Peltzer2,5,6, Stephen M Weiss3, Sibusiso Sifunda2, Deborah L Jones3.   

Abstract

Antiretroviral (ARV) adherence is essential to prevent mother-to-child transmission of HIV. This study compared self-reported adherence versus ARV detection in dried blood spots (DBS) among N = 392 HIV-infected pregnant women in South Africa (SA). Women completed two self-reported adherence measures [visual analog scale (VAS), AIDS Clinical Trials Group Adherence (ACTG)]. Adherence was 89% (VAS), 80% (ACTG), and 74% (DBS). Self-report measures marginally agreed with DBS (VAS: Kappa = 0.101, Area under the ROC curve (AUROC) = 0.543; ACTG: Kappa  = 0.081, AUROC = 0.538). Self-reported adherence was overestimated and agreement with DBS was poor. Validation of self-reported ARV adherence among pregnant HIV+ women in SA is needed.

Entities:  

Keywords:  Adherence; Antiretrovirals; HIV; Measurement; South Africa; Women

Mesh：

Substances：

Year:  2017        PMID： 28361454      PMCID： PMC5493507          DOI： 10.1007/s10461-017-1760-3

Source DB:  PubMed          Journal:  AIDS Behav        ISSN： 1090-7165


  10 in total

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Journal:  J Acquir Immune Defic Syndr       Date:  2013-03-01       Impact factor: 3.731

2.  Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. Patient Care Committee & Adherence Working Group of the Outcomes Committee of the Adult AIDS Clinical Trials Group (AACTG).

Authors:  M A Chesney; J R Ickovics; D B Chambers; A L Gifford; J Neidig; B Zwickl; A W Wu
Journal:  AIDS Care       Date:  2000-06

3.  Short communication: Tenofovir diphosphate in dried blood spots as an objective measure of adherence in HIV-infected women.

Authors:  Jose R Castillo-Mancilla; Kristina Searls; Patricia Caraway; Jia-Hua Zheng; Edward M Gardner; Julie Predhomme; Lane R Bushman; Peter L Anderson; Amie L Meditz
Journal:  AIDS Res Hum Retroviruses       Date:  2014-11-20       Impact factor: 2.205

4.  A simple single-item rating scale to measure medication adherence: further evidence for convergent validity.

Authors:  Seth C Kalichman; Christina M Amaral; Connie Swetzes; Michelle Jones; Rene Macy; Moira O Kalichman; Chauncey Cherry
Journal:  J Int Assoc Physicians AIDS Care (Chic)       Date:  2009 Nov-Dec

5.  Determinants of male involvement in the prevention of mother-to-child transmission of HIV programme in Eastern Uganda: a cross-sectional survey.

Authors:  Robert Byamugisha; James K Tumwine; Nulu Semiyaga; Thorkild Tylleskär
Journal:  Reprod Health       Date:  2010-06-23       Impact factor: 3.223

6.  Measuring adherence to antiretroviral therapy in a diverse population using a visual analogue scale.

Authors:  Thomas P Giordano; David Guzman; Richard Clark; Edwin D Charlebois; David R Bangsberg
Journal:  HIV Clin Trials       Date:  2004 Mar-Apr

7.  No New HIV Infections With Increasing Use of HIV Preexposure Prophylaxis in a Clinical Practice Setting.

Authors:  Jonathan E Volk; Julia L Marcus; Tony Phengrasamy; Derek Blechinger; Dong Phuong Nguyen; Stephen Follansbee; C Bradley Hare
Journal:  Clin Infect Dis       Date:  2015-09-01       Impact factor: 9.079

Review 8.  Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis.

Authors:  Jean B Nachega; Olalekan A Uthman; Jean Anderson; Karl Peltzer; Sarah Wampold; Mark F Cotton; Edward J Mills; Yuh-Shan Ho; Jeffrey S A Stringer; James A McIntyre; Lynne M Mofenson
Journal:  AIDS       Date:  2012-10-23       Impact factor: 4.177

9.  Preexposure prophylaxis for HIV infection among African women.

Authors:  Lut Van Damme; Amy Corneli; Khatija Ahmed; Kawango Agot; Johan Lombaard; Saidi Kapiga; Mookho Malahleha; Fredrick Owino; Rachel Manongi; Jacob Onyango; Lucky Temu; Modie Constance Monedi; Paul Mak'Oketch; Mankalimeng Makanda; Ilse Reblin; Shumani Elsie Makatu; Lisa Saylor; Haddie Kiernan; Stella Kirkendale; Christina Wong; Robert Grant; Angela Kashuba; Kavita Nanda; Justin Mandala; Katrien Fransen; Jennifer Deese; Tania Crucitti; Timothy D Mastro; Douglas Taylor
Journal:  N Engl J Med       Date:  2012-07-11       Impact factor: 91.245

10.  Implementing comprehensive prevention of mother-to-child transmission and HIV prevention for South African couples: study protocol for a randomized controlled trial.

Authors:  Deborah Jones; Karl Peltzer; Stephen M Weiss; Sibusiso Sifunda; Ntabozuko Dwane; Shandir Ramlagan; Ryan Cook; Gladys Matseke; Vincent Maduna; Andrew Spence
Journal:  Trials       Date:  2014-10-27       Impact factor: 2.279
  10 in total
  16 in total

1.  Tenofovir concentrations in hair strongly predict virologic suppression in breastfeeding women.

Authors:  Pamela M Murnane; Peter Bacchetti; Judith S Currier; Sean Brummel; Hideaki Okochi; Nhi Phung; Alexander Louie; Karen Kuncze; Risa M Hoffman; Teacler Nematadzira; Dean K Soko; Maxensia Owor; Friday Saidi; Patricia M Flynn; Mary G Fowler; Monica Gandhi
Journal:  AIDS       Date:  2019-08-01       Impact factor: 4.177

2.  Measuring Adherence to Antiretroviral Therapy via Hair Concentrations in India.

Authors:  Monica Gandhi; Sarita Devi; Peter Bacchetti; Sara Chandy; Elsa Heylen; Nhi Phung; Karen Kuncze; Hideaki Okochi; Ravi Kumar; Anura V Kurpad; Maria L Ekstrand
Journal:  J Acquir Immune Defic Syndr       Date:  2019-06-01       Impact factor: 3.731

3.  Distinct forms of migration and mobility are differentially associated with HIV treatment adherence.

Authors:  Pamela M Murnane; Monica Gandhi; Peter Bacchetti; Monica Getahun; Sarah A Gutin; Hideaki Okochi; Irene Maeri; Patrick Eyul; Daniel Omoding; Jaffer Okiring; Regina Tallerico; Alexander Louie; Adam Akullian; Moses R Kamya; Elizabeth A Bukusi; Edwin D Charlebois; Carol S Camlin
Journal:  AIDS       Date:  2022-03-04       Impact factor: 4.632

4.  Comparison of efavirenz levels in blood and hair with pharmacy refills as measures of adherence and predictors of viral suppression among people living with HIV in Nigeria.

Authors:  Monica Gandhi; Babafemi Taiwo; Jacinta N Nwogu; Samuel O Ngene; Chinedum P Babalola; Adeniyi Olagunju; Andrew Owen; Saye H Khoo; Olayinka A Kotila; Baiba Berzins; Hideaki Okochi; Regina Tallerico
Journal:  AIDS Res Ther       Date:  2022-07-10       Impact factor: 2.846

5.  Who's slipping through the cracks? A comprehensive individual, clinical and health system characterization of people with virological failure on first-line HIV treatment in Uganda and South Africa.

Authors:  Zahra Reynolds; Suzanne M McCluskey; Mahomed Yunus S Moosa; Rebecca F Gilbert; Selvan Pillay; Isaac Aturinda; Kevin L Ard; Winnie Muyindike; Nicholas Musinguzi; Godfrey Masette; Pravi Moodley; Jaysingh Brijkumar; Tamlyn Rautenberg; Gavin George; Brent A Johnson; Rajesh T Gandhi; Henry Sunpath; Vincent C Marconi; Mwebesa Bosco Bwana; Mark J Siedner
Journal:  HIV Med       Date:  2021-11-09       Impact factor: 3.094

Review 6.  Adherence Measurements in HIV: New Advancements in Pharmacologic Methods and Real-Time Monitoring.

Authors:  Jose R Castillo-Mancilla; Jessica E Haberer
Journal:  Curr HIV/AIDS Rep       Date:  2018-02       Impact factor: 5.071

7.  Social Support Mitigates Negative Impact of Food Insecurity on Antiretroviral Adherence Among Postpartum Women in Western Kenya.

Authors:  Mira Wang; Joshua D Miller; Shalean M Collins; Marianne V Santoso; Pauline Wekesa; Hideaki Okochi; Maricianah Onono; Sheri Weiser; Monica Gandhi; Sera L Young
Journal:  AIDS Behav       Date:  2020-10

8.  Alcohol Use and Antiretroviral Therapy Non-Adherence Among Adults Living with HIV/AIDS in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.

Authors:  Jennifer Velloza; Christopher G Kemp; Frances M Aunon; Megan K Ramaiya; Emma Creegan; Jane M Simoni
Journal:  AIDS Behav       Date:  2020-06

9.  Predictors of postpartum HIV care engagement for women enrolled in prevention of mother-to-child transmission (PMTCT) programs in Tanzania.

Authors:  Melissa H Watt; Cody Cichowitz; Godfrey Kisigo; Linda Minja; Brandon A Knettel; Elizabeth T Knippler; James Ngocho; Preeti Manavalan; Blandina T Mmbaga
Journal:  AIDS Care       Date:  2018-11-22

10.  Integrating HIV Preexposure Prophylaxis With Community-Based Syringe Services for Women Who Inject Drugs: Results From the Project SHE Demonstration Study.

Authors:  Alexis M Roth; Nguyen K Tran; Marisa Felsher; Annette B Gadegbeku; Brogan Piecara; Rachel Fox; Douglas S Krakower; Scarlett L Bellamy; K Rivet Amico; Jose A Benitez; Barbara Van Der Pol
Journal:  J Acquir Immune Defic Syndr       Date:  2021-03-01       Impact factor: 3.771
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