| Literature DB >> 32212069 |
Mira Wang1, Joshua D Miller1, Shalean M Collins1, Marianne V Santoso1, Pauline Wekesa2, Hideaki Okochi3, Maricianah Onono2, Sheri Weiser3, Monica Gandhi3, Sera L Young4,5.
Abstract
Food insecurity (FI), low social support, and low health-related quality of life (HRQoL) are associated with self-reported nonadherence to antiretroviral therapy (ART) among postpartum women, but these relationships have not been evaluated using objective adherence indicators. Hair samples were therefore analyzed among 83 postpartum Kenyan women living with HIV on efavirenz and nevirapine ART drug regimens in an observational cohort (NCT02974972). FI (0-27), social support (0-40), and HRQoL (8-40) in the prior month were also assessed. In multivariable models, each point increase in FI and decrease in HRQoL were associated with a 45.1% (95% CI: -64.3%, -15.6%) and 10.5% decrease (95% CI: 1.0%, 22.1%) in hair ART drug concentrations respectively, when social support was held constant. A significant interaction between social support and FI (β = 0.02, p = 0.017) indicated that greater social support was predicted to mitigate the negative impacts of FI on ART adherence. Addressing these modifiable barriers could improve ART adherence during this critical period.Entities:
Keywords: Antiretroviral adherence; Food insecurity; Hair ART drug concentrations; Postpartum; Social support
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Year: 2020 PMID： 32212069 PMCID： PMC7483232 DOI： 10.1007/s10461-020-02839-9
Source DB: PubMed Journal: AIDS Behav ISSN： 1090-7165