| Literature DB >> 2835674 |
V Cherington1, M Brown, E Paucha, J St Louis, B M Spiegelman, T M Roberts.
Abstract
Wild-type simian virus 40 large T antigen is very effective at blocking adipocyte differentiation in 3T3-F442A cells as assayed by triglyceride accumulation, induction of glycerophosphate dehydrogenase activity, and expression of mRNAs for glycerophosphate dehydrogenase, the adipocyte serine protease adipsin, and the putative lipid-binding protein adipocyte P2. Point mutants defective for either origin-specific DNA binding or transformation blocked differentiation as completely as wild type.Entities:
Mesh:
Substances:
Year: 1988 PMID: 2835674 PMCID: PMC363287 DOI: 10.1128/mcb.8.3.1380-1384.1988
Source DB: PubMed Journal: Mol Cell Biol ISSN: 0270-7306 Impact factor: 4.272