Skeletal and dentoalveolar changes after miniscrew-assisted rapid palatal expansion in young adults: A cone-beam computed tomography study.

OBJECTIVE: The aim of this study was to evaluate the skeletal and dentoalveolar changes after miniscrew-assisted rapid palatal expansion (MARPE) in young adults by cone-beam computed tomography (CBCT).
METHODS: This retrospective study included 14 patients (mean age, 20.1 years; range, 16-26 years) with maxillary transverse deficiency treated with MARPE. Skeletal and dentoalveolar changes were evaluated using CBCT images acquired before and after expansion. Statistical analyses were performed using paired t-test or Wilcoxon signed-rank test according to normality of the data.
RESULTS: The midpalatal suture was separated, and the maxilla exhibited statistically significant lateral movement (p < 0.05) after MARPE. Some of the landmarks had shifted forwards or upwards by a clinically irrelevant distance of less than 1 mm. The amount of expansion decreased in the superior direction, with values of 5.5, 3.2, 2.0, and 0.8 mm at the crown, cementoenamel junction, maxillary basal bone, and zygomatic arch levels, respectively (p < 0.05). The buccal bone thickness and height of the alveolar crest had decreased by 0.6-1.1 mm and 1.7-2.2 mm, respectively, with the premolars and molars exhibiting buccal tipping of 1.1°-2.9°.
CONCLUSIONS: Our results indicate that MARPE is an effective method for the correction of maxillary transverse deficiency without surgery in young adults.

INTRODUCTION

Rapid palatal expansion (RPE) has been widely used in the field of orthodontics since the mid-1960s for increasing the transverse dimensions of the maxilla in growing patients.1 Rapid palatal expansion enables the separation of the midpalatal suture, which is followed by skeletal orthopedic expansion.2 Surgically assisted RPE (SARPE) is a treatment modality that helps overcome increased resistance from the bony palate and zygomatic buttress in adults.34 However, SARPE has several limitations, including high cost, a complex treatment process, and surgical morbidity,5 and most patients are reluctant to undergo this surgical procedure. Therefore, several efforts have been made to minimize the surgical risks and limitations of RPE.

Previous histological studies have shown that the midpalatal suture begins to obliterate during the juvenile stage, with a marked degree of closure observed in the third decade of life.67 Therefore, conventional RPE can produce unwanted effects in adults, such as expansion failure, alveolar bone dehiscence, buccal crown tipping, root resorption, reduction in buccal bone thickness, and marginal bone loss.8 To minimize these side effects, orthopedic expansion of the basal bone is essential in non-growing patients.910

Nonsurgical maxillary expansion can be achieved through conventional, bone-anchored, or combination-type RPE. Bone-anchored devices have been reported to successfully expand the maxilla after lateral osteotomy. 411 To ensure expansion of the basal bone without surgical intervention and maintain the separated bone in consolidation, Lee et al.12 introduced miniscrew-assisted RPE (MARPE) and reported successful expansion of the maxilla through opening of the midpalatal suture.

Periapical or occlusal radiographs are adequate for assessing the opening of the midpalatal suture. However, the movements of each tooth and its alveolus are barely identifiable on conventional two-dimensional (2D) radiographs such as lateral or posteroanterior (PA) cephalograms. Cone-beam computed tomography (CBCT) allows imaging at relatively low radiation dosages and presents a clear view of bony structures, with minimal image distortion.13 Skeletal and dentoalveolar changes after conventional tooth-borne and tooth-bone-borne RPE have been investigated using CBCT in growing patients.141516 In contrast, there is limited information regarding nonsurgical expansion using bone-borne techniques such as MARPE in young adults. Therefore, CBCT can be used to accurately assess not only the changes in each tooth and its alveolus, but also quantitative three-dimensional (3D) changes in the maxillofacial complex after MARPE.17

The aim of the present study was to evaluate the following null hypothesis: short-term skeletal and dentoalveolar measurements obtained before and after MARPE in young adults do not differ significantly. To test the hypothesis, CBCT data acquired before and after MARPE were compared.

MATERIALS AND METHODS

Subjects

The CBCT records of 19 patients with maxillary constriction who had undergone maxillary expansion by MARPE between January 2012 and October 2013 and had a complete set of CBCT images acquired before (T1) and after (T2) expansion were retrieved from the archives of the Department of Orthodontics, Yonsei University Dental Hospital. Maxillary constriction was diagnosed at maxillomandibular transverse differential index values > 19.6 mm.18 Of the 19 patients, 5 were excluded on the basis of the following exclusion criteria: failure of opening of the midpalatal suture (n = 3), systemic diseases, craniofacial anomalies (n = 1), and history of orthodontic treatment (n = 1). Finally, 14 patients (male, 9; female, 5) with a mean age of 20.1 ± 2.4 years (range, 16–26 years) were retrospectively enrolled in the study. None of the subjects exhibited functional displacement. The mean duration of expansion was 27 days (range, 18–35 days), and the mean amount of expansion was 6.7 mm (range, 4.5–8.8 mm). The second set of CBCT images were acquired within 5 weeks (mean duration, 10.7 days; range, 1–35 days) of completion of expansion. The mean duration between T1 and T2 was 38 days (range, 24–66 days). This study was approved by the institutional review board of Yonsei University Dental Hospital (No. 2-2015-0017). Because of the retrospective nature of the study, the institutional review board waived the requirement for written informed consent from patients.

The MARPE device was fabricated by modifying the conventional hyrax-type RPE device.12 Four rigid connectors, composed of 0.8-mm stainless steel wire with helical hooks, were soldered onto the base of the conventional hyrax screw body (Hyrax® Click; Dentaurum, Ispringen, Germany). Two anterior hooks were positioned in the rugae area, and two posterior hooks were positioned in the para-midsagittal area. The MARPE device made passive contact with the underlying tissue. Following cementation of the appliance to the maxillary first premolars and molars, four orthodontic miniscrews (Orlus; Ortholution, Seoul, Korea), with a collar diameter of 1.8 mm and length of 7 mm, were placed at the center of each helical hook (Figure 1).12 Maxillary expansion was initiated on the day after MARPE device placement. The appliance was activated at a rate of one turn per day (0.2 mm per turn) until the required expansion was achieved.

Figure 1

Clinical application of miniscrew-assisted rapid palatal expansion.

Measurements

The CBCT device (Alphard VEGA; ASAHI Roentgen IND, Kyoto, Japan) was set at 5.0 mA and 80 kV, and images were acquired for 17 seconds, with a voxel size of 0.3 mm. During image acquisition, the patients were seated upright, with the Frankfort horizontal plane parallel to the floor and the patient's head stabilized by an ear rod. Patients were asked to open their mouth slightly during image acquisition to prevent overlapping of the maxillary and mandibular teeth. The images were imported as digital imaging and communications in medicine (DICOM) files using InVivo5® software (Anatomage, San Jose, CA, USA) and reoriented with the palatal plane parallel to the floor in the sagittal and coronal planes. Subsequent measurements were performed using the same software (InVivo5®).

Interpremolar (IPMW) and intermolar (IMW) widths, defined as the distances between the right and left buccal/mesiobuccal cusp tips of the first premolars and first molars, respectively, were measured on 3D tooth images (Figure 2). For measurement of transverse dimensions, 2D PA cephalograms were reconstructed perpendicular to the midsagittal plane. Bilateral landmarks (Z, N, J, MA, C6, and Ag) were identified in these images, and the distances between right and left corresponding landmarks were measured (Figure 3). The landmarks evaluated in this study and their definitions are summarized in Table 1.

Figure 2

Three-dimensional tooth models used for the cone-beam computed tomography assessment of interpremolar and intermolar widths after miniscrew-assisted rapid palatal expansion.

Solid arrow, interpremolar width; dashed arrow, intermolar width.

Figure 3

Two-dimensional posteroanterior cephalogram reconstructed from a three-dimensional skull model. Refer to Table 1 for the definitions of abbreviations.

Table 1

Definition of landmarks used in this study

Z, N, J, MA, C6, and Ag were identified on the reconstructed two-dimensional posteroanterior cephalogram of a three-dimensional skull model.

Alare, ectocanine, A-point, prosthion, ectomolare, and processus zygomaticus were defined according to the study by Magnusson et al.19

*Although A-point and prosthion were one-point landmarks before expansion, they were separated into right and left landmarks after expansion.

Three-dimensional skull images acquired at T1 and T2 were superimposed using a point-to-point and volumetric registration method with specifically normalized mutual data based on the anterior cranial base (Figure 4).19 Upon volumetric registration, the T1 and T2 images shared the same coordinate system, which compensated for discrepancies and minimized the risk of measurement errors. On each image, six pairs of bony landmarks were identified on the basis of a previous report,19 following which, each landmark was coordinated. Displacements in the maxilla were analyzed along the x, y, and z axes by calculating the deviation of each landmark between T1 and T2. The distances between right and left corresponding landmarks were measured, and the differences between the measurements in T1 and T2 were calculated.

Figure 4

Superimposition of three-dimensional cone-beam computed tomography images acquired before (white) and after (blue) miniscrew-assisted rapid palatal expansion.

1 and 2, alare, right and left; 3 and 4, A-point, right and left; 5 and 6, prosthion, right and left; 7 and 8, ectocanine, right and left; 9 and 10, ectomolare, right and left; 11 and 12, processus zygomaticus, right and left.

Two coronal scans were obtained perpendicular to the midsagittal plane, passing through the buccal/mesiobuccal cusp tips and furcations of the maxillary first premolars and molars. For the maxillary first premolars with a single root, coronal scans were obtained perpendicular to the midsagittal plane, passing through the buccal and palatal cusp tips. For measurement of nasal cavity and basal bone widths, the anterior-most slice showing the entire palatal roots of the maxillary right first premolars and molars was selected (Figure 5). On each image, the following parameters were measured: nasal cavity width, defined as the transverse width between the lateral-most points of each nasal cavity; basal bone width, defined as the transverse width between the right and left intersection points of the maxillary lateral border and a line passing through the nasal floor; interdental angle, defined as an angle between the right and left tooth axes determined by connecting the central fossa and palatal root apex; buccal bone thickness, defined as the distance from the buccal root surface to the outer border of the alveolar bone, along a horizontal line passing through the furcation; and buccal alveolar height, defined as the distance from the buccal/mesiobuccal cusp tip to the buccal alveolar crest. Buccal bone thickness and alveolar height were measured on the right and left sides, and the mean values of the two measurements were used for statistical analyses.

Figure 5

Coronal cone-beam computed tomography images acquired before expansion at furcations of the first premolar (left) and first molar (right).

a, buccal bone thickness; b, buccal alveolar height.

Buccal bone thickness and alveolar height were measured on the right and left sides, and the mean value of the two measurements was calculated.

Statistical analysis

The normality of data was determined using the Shapiro-Wilk test. Comparison of skeletal and dentoalveolar measurements before and after MARPE was performed using paired t-tests or Wilcoxon signed-rank tests, according to the normality of data distribution. Values of p < 0.05 were considered statistically significant. All statistical analyses were performed using the SPSS version 15.0 software (SPSS Inc., Chicago, IL, USA).

A single examiner performed all measurements. To determine the intraexaminer reliability, the same examiner reanalyzed seven randomly selected measurements within a 2-week interval. The resultant intraclass correlation coefficient (ICC) indicated high reliability (ICC > 0.90).

RESULTS

The IPMW and IMW had increased by 5.5 and 5.4 mm, respectively, after MARPE (p < 0.001; Table 2). The midpalatal suture was separated, and the maxilla exhibited statistically significant lateral movement (p < 0.05). The zygomatic arch and nasal cavity were widened by 0.8 and 1.4 mm, respectively, and the lateral contour of the maxillary alveolus exhibited an expansion of 2.0–3.2 mm (p < 0.001). The amount of expansion decreased with the superior positioning of anatomical structures, indicating a pyramidal pattern of maxillary expansion.

Table 2

Comparison of skeletal and dentoalveolar measurements before (T1) and after (T2) expansion (n = 14; mm)

Data are presented as mean ± standard deviation.

IPMW, Interpremolar width; IMW, intermolar width.

Please refer to Table 1 for the definition of each landmark.

Paired t-tests were performed according to the normality of the data; *p < 0.05, ‡p < 0.001.

According to the findings of superimposition of the 3D skull models, all of the evaluated landmarks exhibited significant lateral movement (p < 0.01; Table 3). The alare and ectocanine had shifted forward (p < 0.01), while the prosthion and ectomolare had shifted upward (p < 0.05). The distances between all of the right and left corresponding landmarks had increased after expansion (p < 0.01; Table 4).

Table 3

Displacement in the maxilla, assessed in the transverse (x), sagittal (y), and vertical (z) planes, after expansion (n = 28; mm)

IQR, Interquartile range.

Please refer to Table 1 for the definition of each landmark.

For the x coordinates, absolute values were used. For the y and z coordinates, positive values indicate backward and upward movements, respectively. Measurements were performed on both the right and left sides.

Comparison was performed using the Wilcoxon signed-rank nonparametric test; *p < 0.05, †p < 0.01, ‡p < 0.001.

Table 4

Changes in the distances between the right and left corresponding landmarks after expansion (n = 14; mm)

IQR, Interquartile range.

Please refer to Table 1 for the definition of each landmark.

Comparison was performed using the Wilcoxon signed-rank nonparametric tests; *p < 0.05, †p < 0.01.

Evaluation of coronal images of the first premolars and first molars demonstrated an increase in the nasal cavity width and basal bone width, buccal tipping of the maxillary first molars, and a decrease in the buccal bone thickness and alveolar bone height (p < 0.01; Table 5). The increase in width of the basal bone was greater compared to that of the nasal cavity, which further confirmed the pyramidal pattern of maxillary expansion.

Table 5

Comparison of transverse dimensions before (T1) and after (T2) expansion measured on two-dimensional coronal images (n = 14)

Data are presented as mean ± standard deviation.

PM1, Maxillary first premolar; M1, maxillary first molar.

*Wilcoxon signed-rank nonparametric test was performed because buccal alveolar height was not normally distributed. Other variables were analyzed by paired t-tests; †p < 0.01, ‡p < 0.001.

DISCUSSION

In the present study, we evaluated skeletal and dentoalveolar changes after MARPE in young adults with transverse maxillary discrepancy using CBCT. MARPE effectively achieved dentoalveolar as well as skeletal expansion by separation of the midpalatal suture. The increase in IMW width (5.4 mm) accounted for 37.0% of the skeletal expansion at the J-point (2.0 mm), 22.2% of the alveolar expansion at the cementoenamel junction (1.2 mm), and 40.7% of the dental expansion at the cusp tip (2.2 mm). Despite the decrease in thickness and height of the buccal alveolus and the buccal tipping of the maxillary first molar, the changes observed after MARPE in the present study were similar to those observed after conventional RPE and can be considered clinically insignificant.82021

Two-dimensional PA cephalograms and periapical or occlusal radiographs are considered adequate for ensuring the opening of the midpalatal suture. Apart from the increased radiation dose involved in CBCT, metal artifacts, voxel size, and superimposition errors may affect the spatial resolution of CBCT images, resulting in measurement errors. Nevertheless, the accuracy of CBCT has been well documented,131722 and several reports on the assessment of conventional RPE outcomes using computed tomography or CBCT in growing patients have been published.141516 In the present study, we evaluated CBCT data, the accuracy of which has been verified,1317 to analyze the 3D movements of anatomical landmarks as well as the changes in the buccal alveolar bone, which is not possible with 2D modalities.

The bone-borne nature of the MARPE device can result in skeletal and alveolar expansion in young adults despite the increased resistance of the midpalatal and circumaxillary sutures from the age of 14–16 years.623 Among the 19 patients treated by MARPE in the present study, only 3 exhibited failure of opening of the midpalatal suture and were excluded, resulting in a success rate of 84.2%. Skeletal expansion observed in the present study included the expansion of the zygomatic arch as well as nasal cavity. While the zygomatic arch expanded by less than 1 mm, the expansion of the nasal cavity was more evident and would have resulted in increased air flow and improved nasal breathing.224 Thus, in the coronal plane, maxillary expansion followed a pyramidal pattern, similar to the expansion pattern reported with conventional RPE or SARPE.82021

In the axial plane, however, the expansion did not demonstrate a pyramidal pattern, as previously reported.215 The amount of expansion was similar between the anterior and posterior regions at the crown (IPMW and IMW) and alveolar crest (prosthion, ectocanine, and ectomolare) levels. However, nasal cavity width in the premolar region had increased more obviously compared to that in the molar region, which may be attributed to the variations in nasal concha. Distribution of resistance from the maxilla might also cause parallel expansion. In similar age groups treated with SARPE, while parallel expansion of the maxilla was observed upon the release of pterygoid plates,11 the amount of anterior expansion was found to be greater than the amount of posterior expansion when only the pterygoid plates were not released.425

In the sagittal and vertical directions, MARPE did not result in clinically significant changes. On the 3D skull images, some of the landmarks exhibited forward or upward movements of less than 1 mm. These movements might have resulted from changes in not only circumaxillary sutures, but also the spheno-occipital synchondrosis and orbital structures.26

The activation force of an RPE device initially results in the compression of the periodontal ligament, bending of the alveolar bone, and tipping of the anchored teeth.2 Therefore, a 1°–24°-increase in molar inclination is inevitable, probably because of alveolar bending and/or tipping of the posterior teeth.27 Previous studies regarding RPE and SARPE reported buccal tipping of 4.95°–6.9° of the maxillary first molar.1528 These values are similar to those observed in the present study. The degree of buccal tipping of the first molar was greater compared to that of the first premolar. However, the first premolar exhibited similar or slightly greater increases in IMW, IPMW, nasal cavity, and basal bone widths than the first molar. Garib et al.21 also reported greater changes in the degree of molar inclination than that of premolar inclination. The higher density of the buccal cortical bone in the maxillary canine and premolar regions29 might have resulted in the greater buccal inclination of the first molar in comparison with that of the first premolar.

Tipping movements might cause changes in the alveolar bone.1030 In the present study, we observed decreases in buccal plate thickness (0.6–1.1 mm) and buccal alveolar crest height (1.7–2.2 mm) after MARPE. However, the buccal alveolar height might have been underestimated because of the tipping movements. In previous studies, RPE and SARPE were found to induce a similar decrease in buccal bone plate thickness.2021 In one of the previous studies,20 the teeth appeared to have moved through the alveolus, resulting in decreased buccal bone thickness and increased lingual bone thickness. Tipping movements, which indicate greater lateral movement at the cervical level than at the apical level, along with the decrease in the alveolar bone thickness, might lead to the decrease in buccal alveolar crest height, which can eventually result in gingival recession. In children, the decrease in buccal alveolar crest height at the maxillary first molar after conventional RPE was reported to be approximately 1.23 mm,31 which is comparable to the corresponding value observed in the present study. Despite the lack of evidence regarding alveolar bone loss and subsequent gingival recession due to RPE,32 the amount of marginal bone loss after RPE might be an indicator of future gingival recession, which calls for attention from the attending clinician.

The amount of appliance expansion (6.7 mm) was greater than the increase in the IPMW/IMW (5.5/5.4 mm). This could indicate errors in counting of the number of appliance turns, because the amount of expansion was calculated on the basis of patient reports. Alternatively, it could indicate deformation of the appliance. Because of the controversies regarding nonsurgical expansion in adults,23 we were unable to address the effects of conventional RPE in patients with maxillary constriction. Additionally, because of ethical considerations, we could not include a control group of untreated patients in our study. Our study sample comprised only 14 young adults, which places emphasis on the necessity of further prospective studies involving larger numbers of patients and long-term evaluation of stability and periodontal adaptation after MARPE.

CONCLUSION

The null hypothesis was rejected. Within the limitations of this study, our results suggest the following.

MARPE can be an effective treatment modality for the correction of maxillary transverse deficiency in young adults through separation of the midpalatal suture.

Maxillary expansion achieved with MARPE exhibits a pyramidal pattern. In the present study, the degrees of skeletal, alveolar, and dental expansion were 37.0%, 22.2%, and 40.7%, respectively.

Buccal tipping of maxillary teeth upon MARPE leads to the decrease in buccal alveolar bone thickness and crest height. Attending orthodontists should pay attention to these changes.