| Literature DB >> 28329310 |
Sulggi Lee1, Helen Byakwaga2, Yap Boum2, Tricia H Burdo3, Kenneth C Williams4, Michael M Lederman5, Yong Huang1, Russell P Tracy6, Huyen Cao7, Jessica E Haberer8,9, Annet Kembabazi2, David R Bangsberg10, Jeffrey N Martin1, Peter W Hunt1.
Abstract
The plasma kynurenine/tryptophan (KT) ratio, a marker of adaptive immune defects, strongly predicts mortality during treated human immunodeficiency virus (HIV) disease in Ugandans as compared to US-based populations. Here, the KT ratio and T-cell and plasma biomarkers of immune activation were measured among 535 HIV-infected Ugandans prior to ART initiation and at month 6 of viral suppression. The month 6 KT ratio (adjusted hazard ratio [aHR], 2.74), soluble CD14 level (aHR, 2.32), interleukin 6 level (aHR, 2.34), and D-dimer level (aHR, 1.95) were associated with mortality occurring ≥6 months after ART initiation. The KT ratio remained significantly predictive of mortality even after adjustment for the additional biomarkers, suggesting an independent contribution to clinical outcomes in resource-limited settings.Entities:
Keywords: Africa.; D-dimer; HIV; IL-6; antiretroviral therapy; kynurenine; mortality; sCD14; tryptophan
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Year: 2017 PMID： 28329310 PMCID： PMC5853335 DOI： 10.1093/infdis/jix113
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226