| Literature DB >> 28324863 |
Longguang Tang1, Fuwu Zhang2, Fei Yu1, Wenjing Sun1, Menglin Song1, Xiaoyuan Chen2, Xianzhong Zhang3, Xiaolian Sun4.
Abstract
A novel nanoparticle self-assembled by polyethylene glycol (PEG) modified croconaine dye (CR780) is presented for photoacoustic (PA)/near-infrared (NIR) fluorescence imaging-guided photothermal therapy (PTT). The simple PEGylation made CR780 amphiphilic, and led to their self-assembly into well-defined and uniform nanostructures with size tunable by controlling the assembly conditions. The CR780-PEG5K not only displayed the strength of small molecules (including rapid distribution to different organs, fast renal clearance and minimal accumulation to normal tissues), but also demonstrated the advantages of nanomaterials (including high physiological stability, multimodal theranostic ability, high tumor accumulation and retention). These facilely synthesized molecular nanoprobes showed great clinical translation potential as a versatile theranostic agent.Entities:
Keywords: Controlled assembly; EPR effect; Molecular nanoprobe; Multimodality imaging; Photothermal therapy
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Year: 2017 PMID： 28324863 DOI： 10.1016/j.biomaterials.2017.03.009
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479