Photoacoustic imaging (PAI) is a rapidly growing field which offers high spatial resolution and high contrast for deep-tissue imaging in vivo. PAI is nonionizing and noninvasive and combines the optical resolution of fluorescence imaging with the spatial resolution of ultrasound imaging. In particular, the development of exogenous PA contrast agents has gained significant momentum of late with a vastly expanding complexity of dye materials under investigation ranging from small molecules to macromolecular proteins, polymeric and inorganic nanoparticles. The goal of this review is to survey the current state of the art in molecular photoacoustic contrast agents (MPACs) for applications in biomedical imaging. The fundamental design principles of MPACs are presented and a review of prior reports spanning from early-to-current literature is put forth.
Photoacoustic imaging (pan class="Gene">PAI) is a rapidly growing field which offers high spatial resolution and high contrast for deep-tissue imaging in vivo. PAI is nonionizing and noninvasive and combines the optical resolution of fluorescence imaging with the spatial resolution of ultrasound imaging. In particular, the development of exogenous PA contrast agents has gained significant momentum of late with a vastly expanding complexity of dye materials under investigation ranging from small molecules to macromolecular proteins, polymeric and inorganic nanoparticles. The goal of this review is to survey the current state of the art in molecular photoacoustic contrast agents (MPACs) for applications in biomedical imaging. The fundamental design principles of MPACs are presented and a review of prior reports spanning from early-to-current literature is put forth.
Authors: Zheng Zhao; Chao Chen; Wenting Wu; Fenfen Wang; Lili Du; Xiaoyan Zhang; Yu Xiong; Xuewen He; Yuanjing Cai; Ryan T K Kwok; Jacky W Y Lam; Xike Gao; Pingchuan Sun; David Lee Phillips; Dan Ding; Ben Zhong Tang Journal: Nat Commun Date: 2019-02-15 Impact factor: 14.919
Authors: Helen R Salinas; Dominie L Miyasato; Olga E Eremina; Rodolfo Perez; Karen L Gonzalez; Alexander T Czaja; Sean Burkitt; Arjun Aron; Augusta Fernando; Lauro S Ojeda; Kimberly N Larson; Ahmed W Mohamed; Jos L Campbell; Beth A Goins; Cristina Zavaleta Journal: Biomater Sci Date: 2020-08-19 Impact factor: 6.843