Literature DB >> 28318088

Twenty-five Years of DNA-Encoded Chemical Libraries.

Dario Neri1.   

Abstract

Reference library: The availability of DNA-encoded chemical libraries containing billions of compounds facilitates the discovery of binding molecules for pharmaceutical applications and for investigating biological processes. This Special Issue highlights the use of this library technology and some of the latest developments in the field.
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords:  DNA; chemical libraries; drug development; drug discovery

Mesh：

Substances：

Year:  2017        PMID： 28318088     DOI： 10.1002/cbic.201700130

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  7 in total

1.  Multistep Synthesis of 1,2,4-Oxadiazoles via DNA-Conjugated Aryl Nitrile Substrates.

Authors:  Huang-Chi Du; Madison C Bangs; Nicholas Simmons; Martin M Matzuk
Journal:  Bioconjug Chem       Date:  2019-04-10       Impact factor: 4.774

2.  Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support.

Authors:  Dillon T Flood; Shota Asai; Xuejing Zhang; Jie Wang; Leonard Yoon; Zoë C Adams; Blythe C Dillingham; Brittany B Sanchez; Julien C Vantourout; Mark E Flanagan; David W Piotrowski; Paul Richardson; Samantha A Green; Ryan A Shenvi; Jason S Chen; Phil S Baran; Philip E Dawson
Journal:  J Am Chem Soc       Date:  2019-06-12       Impact factor: 15.419

3.  RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis.

Authors:  Dillon T Flood; Xuejing Zhang; Xiang Fu; Zhenxiang Zhao; Shota Asai; Brittany B Sanchez; Emily J Sturgell; Julien C Vantourout; Paul Richardson; Mark E Flanagan; David W Piotrowski; Dominik K Kölmel; Jinqiao Wan; Mei-Hsuan Tsai; Jason S Chen; Phil S Baran; Philip E Dawson
Journal:  Angew Chem Int Ed Engl       Date:  2020-03-11       Impact factor: 15.336

4.  A Mild, DNA-Compatible Nitro Reduction Using B2(OH)4.

Authors:  Huang-Chi Du; Nicholas Simmons; John C Faver; Zhifeng Yu; Murugesan Palaniappan; Kevin Riehle; Martin M Matzuk
Journal:  Org Lett       Date:  2019-03-12       Impact factor: 6.005

5.  Merging C(sp3)-H activation with DNA-encoding.

Authors:  Zhoulong Fan; Shuai Zhao; Tao Liu; Peng-Xiang Shen; Zi-Ning Cui; Zhe Zhuang; Qian Shao; Jason S Chen; Anokha S Ratnayake; Mark E Flanagan; Dominik K Kölmel; David W Piotrowski; Paul Richardson; Jin-Quan Yu
Journal:  Chem Sci       Date:  2020-09-07       Impact factor: 9.825

6.  DNA-Encoded Library Hit Confirmation: Bridging the Gap Between On-DNA and Off-DNA Chemistry.

Authors:  Bing Xia; G Joseph Franklin; Xiaojie Lu; Katie L Bedard; LaShadric C Grady; Jennifer D Summerfield; Eric X Shi; Bryan W King; Kenneth E Lind; Cynthia Chiu; Eleanor Watts; Vera Bodmer; Xiaopeng Bai; Lisa A Marcaurelle
Journal:  ACS Med Chem Lett       Date:  2021-06-03       Impact factor: 4.632

7.  C-N Coupling of DNA-Conjugated (Hetero)aryl Bromides and Chlorides for DNA-Encoded Chemical Library Synthesis.

Authors:  Ying-Chu Chen; John C Faver; Angela F Ku; Gabriella Miklossy; Kevin Riehle; Kurt M Bohren; Melek N Ucisik; Martin M Matzuk; Zhifeng Yu; Nicholas Simmons
Journal:  Bioconjug Chem       Date:  2020-02-21       Impact factor: 4.774
  7 in total

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