Toril Marie Terum1,2,3,4, John Roger Andersen1,4, Arvid Rongve3,5, Dag Aarsland2,6, Ellen J Svendsboe2,7,8, Ingelin Testad2,6. 1. Westeren Norway University of Applied Science, Førde, Norway. 2. Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway. 3. Department of Clinical Medicine, University of Bergen, Bergen, Norway. 4. Center of Health Research, Førde Hospital Trust, Førde, Norway. 5. Department of Research and Innovation, Helse Fonna, Haugesund, Norway. 6. Wolfson Centre for Age-Related Diseases, King's College London, London, UK. 7. Department of Nursing, Westeren Norway University of Applied Science, Stord, Norway. 8. Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Huddinge, Sweden.
Abstract
OBJECTIVE: Neuropsychiatric symptoms (NPSs) are common in dementia, and they have been identified as important care-recipient variables in terms of their impact on caregiver burden. The aim of this review was to describe how individual NPSs in dementia, assessed using the Neuropsychiatric Inventory, are associated with caregiver burden. METHODS: We performed a systematic review of English language, peer-reviewed articles retrieved from MEDLINE, PSYCINFO, and EMBASE. RESULTS: A total of 13 studies met the inclusion criteria. Four studies examined the association between individual NPSs and caregiver burden using the Spearman rank correlation test, while three used Pearson's correlation test. Of the remaining studies, five used multiple regression analyses and one the chi-squared test. The majority of included studies did not differentiate between dementia subtypes in the analysis or mainly included only caregivers of people with Alzheimer's disease. The Clinical Dementia Rating score and mean Mini-Mental State Examination score indicate mild to moderate dementia. The majority of caregivers were women, most of whom were children (53.8%) or spouses (36%). The data indicated that irritability, followed by agitation, sleep disturbances, anxiety, apathy, and delusion seem to impact caregiver burden the most. CONCLUSION: Our principal finding is that irritability, agitation, sleep disturbances, anxiety, apathy, and delusion seem to exert the most impact on caregiver burden. Heterogeneity in the measures and statistical analyses used, however, makes it difficult to make conclusive interpretations. Future research in this field would benefit from standardization of the scientific methodology in use.
OBJECTIVE:Neuropsychiatric symptoms (NPSs) are common in dementia, and they have been identified as important care-recipient variables in terms of their impact on caregiver burden. The aim of this review was to describe how individual NPSs in dementia, assessed using the Neuropsychiatric Inventory, are associated with caregiver burden. METHODS: We performed a systematic review of English language, peer-reviewed articles retrieved from MEDLINE, PSYCINFO, and EMBASE. RESULTS: A total of 13 studies met the inclusion criteria. Four studies examined the association between individual NPSs and caregiver burden using the Spearman rank correlation test, while three used Pearson's correlation test. Of the remaining studies, five used multiple regression analyses and one the chi-squared test. The majority of included studies did not differentiate between dementia subtypes in the analysis or mainly included only caregivers of people with Alzheimer's disease. The Clinical Dementia Rating score and mean Mini-Mental State Examination score indicate mild to moderate dementia. The majority of caregivers were women, most of whom were children (53.8%) or spouses (36%). The data indicated that irritability, followed by agitation, sleep disturbances, anxiety, apathy, and delusion seem to impact caregiver burden the most. CONCLUSION: Our principal finding is that irritability, agitation, sleep disturbances, anxiety, apathy, and delusion seem to exert the most impact on caregiver burden. Heterogeneity in the measures and statistical analyses used, however, makes it difficult to make conclusive interpretations. Future research in this field would benefit from standardization of the scientific methodology in use.
Authors: Ye Tao; Matthew E Peters; Lea T Drye; Davangere P Devanand; Jacobo E Mintzer; Bruce G Pollock; Anton P Porsteinsson; Paul B Rosenberg; Lon S Schneider; David M Shade; Daniel Weintraub; Jerome Yesavage; Constantine G Lyketsos; Cynthia A Munro Journal: Am J Alzheimers Dis Other Demen Date: 2018-07-03 Impact factor: 2.035
Authors: Elizabeth K Vernon; Bryce Cooley; William Rozum; Gail B Rattinger; Stephanie Behrens; Joshua Matyi; Elizabeth Fauth; Constantine G Lyketsos; JoAnn T Tschanz Journal: Am J Geriatr Psychiatry Date: 2018-12-01 Impact factor: 4.105
Authors: Lucas S Broster; Shonna L Jenkins; Sarah D Holmes; Matthew G Edwards; Gregory A Jicha; Yang Jiang Journal: Neuropsychologia Date: 2018-05-07 Impact factor: 3.139