Literature DB >> 28315368

The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer.

Jennifer M Spangle1, Thomas M Roberts2, Jean J Zhao3.   

Abstract

The PI3-kinase/AKT pathway integrates signals from external cellular stimuli to regulate essential cellular functions, and is frequently aberrantly activated in human cancers. Recent research demonstrates that tight regulation of the epigenome is critical in preserving and restricting transcriptional activation, which can impact cellular growth and proliferation. In this review we examine mechanisms by which the PI3K/AKT pathway regulates the epigenome to promote oncogenesis, and highlight how connections between PI3K/AKT and the epigenome may impact the future therapeutic treatment of cancers featuring a hyperactivated PI3K/AKT pathway.
Copyright © 2017 Elsevier B.V. All rights reserved.

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Year:  2017        PMID： 28315368      PMCID： PMC5548615          DOI： 10.1016/j.bbcan.2017.03.002

Source DB:  PubMed          Journal:  Biochim Biophys Acta Rev Cancer        ISSN： 0304-419X            Impact factor:   10.680


  69 in total

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Review 3.  New and emerging HDAC inhibitors for cancer treatment.

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8.  PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer.

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  44 in total

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Journal:  Mol Neurobiol       Date:  2021-01-22       Impact factor: 5.590

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Authors:  Jennifer M Spangle; Thomas M Roberts
Journal:  J Mol Med (Berl)       Date:  2017-06-06       Impact factor: 4.599

Review 3.  Signaling Pathways in Leukemic Stem Cells.

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Journal:  Cell Cycle       Date:  2022-05-31       Impact factor: 5.173

6.  Morphine inhibits the promotion of inflammatory microenvironment on chronic tibial cancer pain through the PI3K-Akt-NF-κB pathway.

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7.  Long non-coding RNA GPR65-1 is up-regulated in gastric cancer and promotes tumor growth through the PTEN-AKT-slug signaling pathway.

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Review 10.  Migration and Adhesion of B-Lymphocytes to Specific Microenvironments in Mantle Cell Lymphoma: Interplay between Signaling Pathways and the Epigenetic Landscape.

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