Literature DB >> 2829953

Hypokalaemia and other non-bronchial effects of inhaled fenoterol and salbutamol: a placebo-controlled dose-response study in healthy volunteers.

M Scheinin1, M Koulu, E Laurikainen, H Allonen.   

Abstract

1. The hypokalaemia-inducing effects of two widely used inhaled antiasthmatic beta 2-adrenoceptor agonists, fenoterol and salbutamol, were compared in six healthy male volunteers. 2. Each drug was administered in three different doses, 400, 600 and 800 micrograms, which were repeated three times with 30 min intervals (total doses 1200, 1800 and 2400 micrograms in 1 h). The treatments were given at 1 week intervals in random order in a single-blind fashion. 3. The concentration of potassium in plasma was dose-dependently reduced by both drugs with peak effects 75-90 min after the first inhalations. The hypokalaemic effect of fenoterol was significantly greater than that of equal doses of salbutamol (average +/- s.d. reductions of 1.13 +/- 0.32 and 0.67 +/- 0.25 mEq l-1, respectively, after the highest doses, P less than 0.05). Concomitantly, decreases were noted in the amplitude of the T-wave on the ECG. 4. The concentration of cyclic AMP in plasma was measured and used as an indicator of systemic beta 2-adrenoceptor agonistic effects of the drugs. Increases in cAMP were a close mirror image of the drugs' effects on potassium in plasma. 5. Plasma renin activity, noradrenaline in plasma and heart rate were also dose-dependently increased by the treatments, whereas blood pressure remained unaltered. 6. While the clinical significance of hypokalaemia induced by inhaled beta 2-adrenoceptor sympathomimetics still is a matter of debate, our results point to possible differences between therapeutically equipotent doses of fenoterol and salbutamol in their propensity to cause hypokalaemia and other acute non-bronchial effects.

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Year:  1987        PMID: 2829953      PMCID: PMC1386337          DOI: 10.1111/j.1365-2125.1987.tb03224.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN: 0306-5251            Impact factor:   4.335


  31 in total

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2.  Parenteral adrenergic bronchodilators and potassium.

Authors:  M Küng
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3.  The role of insulin in beta 2-receptor mediated hypokalemia.

Authors:  F Massara; M Porta; V Martina
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4.  Elevated plasma noradrenaline in response to beta-adrenoceptor stimulation in man.

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5.  The proper use of metered dose inhalers.

Authors:  S P Newman; S W Clarke
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6.  Treatment of attacks in hyperkalaemic familial periodic paralysis by inhalation of salbutamol.

Authors:  P Wang; T Clausen
Journal:  Lancet       Date:  1976-01-31       Impact factor: 79.321

7.  Effect of intravenous infusion of salbutamol on ventilatory response to carbon dioxide and hypoxia and on heart rate and plasma potassium in normal men.

Authors:  A G Leitch; L J Clancy; J F Costello; D C Flenley
Journal:  Br Med J       Date:  1976-02-14

8.  Efficacy of parenteral albuterol in the treatment of asthma. Comparison of its metabolic side effects with subcutaneous epinephrine.

Authors:  A S Rohr; S L Spector; G S Rachelefsky; R M Katz; S C Siegel
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9.  Cardiopulmonary effects of fenoterol and salbutamol aerosols.

Authors:  M K Tandon
Journal:  Chest       Date:  1980-03       Impact factor: 9.410

10.  Epinephrine and norepinephrine are cleared through beta-adrenergic, but not alpha-adrenergic, mechanisms in man.

Authors:  P E Cryer; R A Rizza; M W Haymond; J E Gerich
Journal:  Metabolism       Date:  1980-11       Impact factor: 8.694

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  36 in total

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Authors:  J G Maconochie; J K Forster
Journal:  Br J Clin Pharmacol       Date:  1992-03       Impact factor: 4.335

2.  Beta-adrenoceptor responses to inhaled salbutamol in normal subjects.

Authors:  B J Lipworth; D G McDevitt
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

Review 3.  Safety Considerations with Dual Bronchodilator Therapy in COPD: An Update.

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4.  Inhibition of monoamine oxidase by moclobemide: effects on monoamine metabolism and secretion of anterior pituitary hormones and cortisol in healthy volunteers.

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Journal:  Br J Clin Pharmacol       Date:  1989-02       Impact factor: 4.335

5.  Cardiovascular and hypokalaemic effects of inhaled salbutamol, fenoterol, and isoprenaline.

Authors:  J Crane; C Burgess; R Beasley
Journal:  Thorax       Date:  1989-02       Impact factor: 9.139

6.  K2P potassium channels, mysterious and paradoxically exciting.

Authors:  Steve A N Goldstein
Journal:  Sci Signal       Date:  2011-07-26       Impact factor: 8.192

7.  Fenoterol stimulates human erythropoietin production via activation of the renin angiotensin system.

Authors:  S M Freudenthaler; T Schenck; I Lucht; C H Gleiter
Journal:  Br J Clin Pharmacol       Date:  1999-10       Impact factor: 4.335

8.  The effects of the COMT inhibitor nitecapone for one week on exercise haemodynamics and catecholamine disposition.

Authors:  S Sundberg; M Scheinin; P Ojala-Karlsson; J Akkila; A Gordin
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953

9.  The cardiovascular effects of beta adrenergic agonist drugs administered by nebulisation.

Authors:  A Flatt; J Crane; G Purdie; T Kwong; R Beasley; C Burgess
Journal:  Postgrad Med J       Date:  1990-02       Impact factor: 2.401

10.  Salbutamol disposition and dynamics in conscious rabbits: influence of the route of administration and of the dose.

Authors:  S Perreault; H Ong; P du Souich
Journal:  J Pharmacokinet Biopharm       Date:  1992-10
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