Literature DB >> 2829941

Enkephalinase inhibition: regulation of ethanol intake in genetically predisposed mice.

K Blum1, A H Briggs, M C Trachtenberg, L Delallo, J E Wallace.   

Abstract

This is the first report of alteration in alcohol intake in mice with a genetic predisposition to alcohol preference and known to have innate brain enkephalin deficiencies. We have been able to significantly attenuate both volitional and forced ethanol intake respectively by acute and chronic treatment with hydrocinnamic acid and D-phenylalanine, known carboxypeptidase (enkephalinase) inhibitors. Since these agents, through their enkephalinase inhibitory activity, raise brain enkephalin levels, we propose that excessive alcohol intake can be regulated by alteration of endogenous brain opioid peptides.

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Year:  1987        PMID： 2829941     DOI： 10.1016/0741-8329(87)90084-x

Source DB:  PubMed          Journal:  Alcohol        ISSN： 0741-8329            Impact factor:   2.405


  24 in total

1.  Importance of delta opioid receptors in maintaining high alcohol drinking.

Authors:  J C Froehlich; M Zweifel; J Harts; L Lumeng; T K Li
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

2.  Fifty Years in the Development of a Glutaminergic-Dopaminergic Optimization Complex (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome: A Pictorial.

Authors:  K Blum; M Febo; R D Badgaiyan
Journal:  Austin Addict Sci       Date:  2016-10-12

3.  Hypothesizing That Neuropharmacological and Neuroimaging Studies of Glutaminergic-Dopaminergic Optimization Complex (KB220Z) Are Associated With "Dopamine Homeostasis" in Reward Deficiency Syndrome (RDS).

Authors:  Kenneth Blum; Marcelo Febo; Lyle Fried; Mona Li; Kristina Dushaj; Eric R Braverman; Thomas McLaughlin; Bruce Steinberg; Rajendra D Badgaiyan
Journal:  Subst Use Misuse       Date:  2016-12-29       Impact factor: 2.164

Review 4.  Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use.

Authors:  Jessica R Barson; Irene Morganstern; Sarah F Leibowitz
Journal:  ILAR J       Date:  2012

5.  Acute ethanol administration differentially alters enkephalinase and aminopeptidase N activity and mRNA levels in regions of the nigrostriatal pathway.

Authors:  Marcela Morales-Mulia; Patricia de Gortari; María-Isabel Amaya; Milagros Méndez
Journal:  J Mol Neurosci       Date:  2012-06-12       Impact factor: 3.444

6.  Activity and expression of enkephalinase and aminopeptidase N in regions of the mesocorticolimbic system are selectively modified by acute ethanol administration.

Authors:  Marcela Morales-Mulia; Patricia de Gortari; María-Isabel Amaya; Milagros Méndez
Journal:  J Mol Neurosci       Date:  2011-08-26       Impact factor: 3.444

7.  Nicotinamide Adenine Dinucleotide (NAD+) and Enkephalinase Inhibition (IV1114589NAD) Infusions Significantly Attenuate Psychiatric Burden Sequalae in Substance Use Disorder (SUD) in Fifty Cases.

Authors:  Kenneth Blum; David Han; David Baron; Shan Kazmi; Igor Elman; Luis Llanos Gomez; Marjorie C Gondre-Lewis; Panyotis K Thanos; Eric R Braverman; Rajendra D Badgaiyan
Journal:  Curr Psychiatry Res Rev       Date:  2022-06-21

8.  Early intervention of intravenous KB220IV--neuroadaptagen amino-acid therapy (NAAT) improves behavioral outcomes in a residential addiction treatment program: a pilot study.

Authors:  Merlene Miller; Amanda L C Chen; Stan D Stokes; Susan Silverman; Abdalla Bowirrat; Matthew Manka; Debra Manka; David K Miller; Kenneth Perrine; Thomas J H Chen; John A Bailey; William Downs; Roger L Waite; Margaret A Madigan; Eric R Braverman; Uma Damle; Mallory Kerner; John Giordano; Siobhan Morse; Marlene Oscar-Berman; Debmalya Barh; Kenneth Blum
Journal:  J Psychoactive Drugs       Date:  2012 Nov-Dec

9.  Neurogenetics and Nutrigenomics of Neuro-Nutrient Therapy for Reward Deficiency Syndrome (RDS): Clinical Ramifications as a Function of Molecular Neurobiological Mechanisms.

Authors:  Kenneth Blum; Marlene Oscar-Berman; Elizabeth Stuller; David Miller; John Giordano; Siobhan Morse; Lee McCormick; William B Downs; Roger L Waite; Debmalya Barh; Dennis Neal; Eric R Braverman; Raquel Lohmann; Joan Borsten; Mary Hauser; David Han; Yijun Liu; Manya Helman; Thomas Simpatico
Journal:  J Addict Res Ther       Date:  2012-11-27

Review 10.  Isoquinolines, beta-carbolines and alcohol drinking: involvement of opioid and dopaminergic mechanisms.

Authors:  R D Myers
Journal:  Experientia       Date:  1989-05-15
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