Literature DB >> 28298421

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.

S Munir Alam1,2,3, Baptiste Aussedat4, Yusuf Vohra4, R Ryan Meyerhoff1,5, Evan M Cale6, William E Walkowicz4, Nathan A Radakovich6, Kara Anasti1, Lawrence Armand1, Robert Parks1, Laura Sutherland1, Richard Scearce1, M Gordon Joyce6, Marie Pancera6, Aliaksandr Druz6, Ivelin S Georgiev6, Tarra Von Holle1, Amanda Eaton1, Christopher Fox7, Steven G Reed7, Mark Louder6, Robert T Bailer6, Lynn Morris8,9, Salim S Abdool-Karim8,9, Myron Cohen10, Hua-Xin Liao1,2, David C Montefiori1,2,11, Peter K Park4, Alberto Fernández-Tejada4, Kevin Wiehe1, Sampa Santra12, Thomas B Kepler13, Kevin O Saunders1,11, Joseph Sodroski14, Peter D Kwong6, John R Mascola6, Mattia Bonsignori1,2, M Anthony Moody1,5,15, Samuel Danishefsky4, Barton F Haynes1,2,5.   

Abstract

A goal for an HIV-1 vaccine is to overcome virus variability by inducing broadly neutralizing antibodies (bnAbs). One key target of bnAbs is the glycan-polypeptide at the base of the envelope (Env) third variable loop (V3). We have designed and synthesized a homogeneous minimal immunogen with high-mannose glycans reflective of a native Env V3-glycan bnAb epitope (Man9-V3). V3-glycan bnAbs bound to Man9-V3 glycopeptide and native-like gp140 trimers with similar affinities. Fluorophore-labeled Man9-V3 glycopeptides bound to bnAb memory B cells and were able to be used to isolate a V3-glycan bnAb from an HIV-1-infected individual. In rhesus macaques, immunization with Man9-V3 induced V3-glycan-targeted antibodies. Thus, the Man9-V3 glycopeptide closely mimics an HIV-1 V3-glycan bnAb epitope and can be used to isolate V3-glycan bnAbs.
Copyright © 2017, American Association for the Advancement of Science.

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Year:  2017        PMID： 28298421      PMCID： PMC5562351          DOI： 10.1126/scitranslmed.aai7521

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  41 in total

1.  Direct synthesis of beta-mannans. A hexameric [-->3)-beta-D-Man-(1](3) subunit of the antigenic polysaccharides from Leptospira biflexa and the octameric (1-->2)-linked beta-D-mannan of the Candida albicans phospholipomannan. X-ray crystal structure of a protected tetramer.

Authors:  D Crich; H Li; Q Yao; D J Wink; R D Sommer; A L Rheingold
Journal:  J Am Chem Soc       Date:  2001-06-20       Impact factor: 15.419

2.  An advance in the chemical synthesis of homogeneous N-linked glycopolypeptides by convergent aspartylation.

Authors:  Ping Wang; Baptiste Aussedat; Yusufbhai Vohra; Samuel J Danishefsky
Journal:  Angew Chem Int Ed Engl       Date:  2012-09-25       Impact factor: 15.336

3.  Enzyme digests eliminate nonfunctional Env from HIV-1 particle surfaces, leaving native Env trimers intact and viral infectivity unaffected.

Authors:  Ema T Crooks; Tommy Tong; Keiko Osawa; James M Binley
Journal:  J Virol       Date:  2011-04-06       Impact factor: 5.103

4.  Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals.

Authors:  Johannes F Scheid; Hugo Mouquet; Niklas Feldhahn; Michael S Seaman; Klara Velinzon; John Pietzsch; Rene G Ott; Robert M Anthony; Henry Zebroski; Arlene Hurley; Adhuna Phogat; Bimal Chakrabarti; Yuxing Li; Mark Connors; Florencia Pereyra; Bruce D Walker; Hedda Wardemann; David Ho; Richard T Wyatt; John R Mascola; Jeffrey V Ravetch; Michel C Nussenzweig
Journal:  Nature       Date:  2009-03-15       Impact factor: 49.962

5.  Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1.

Authors:  Marcella Sarzotti-Kelsoe; Robert T Bailer; Ellen Turk; Chen-li Lin; Miroslawa Bilska; Kelli M Greene; Hongmei Gao; Christopher A Todd; Daniel A Ozaki; Michael S Seaman; John R Mascola; David C Montefiori
Journal:  J Immunol Methods       Date:  2013-12-01       Impact factor: 2.303

6.  Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.

Authors:  Hua-Xin Liao; Mattia Bonsignori; S Munir Alam; Jason S McLellan; Georgia D Tomaras; M Anthony Moody; Daniel M Kozink; Kwan-Ki Hwang; Xi Chen; Chun-Yen Tsao; Pinghuang Liu; Xiaozhi Lu; Robert J Parks; David C Montefiori; Guido Ferrari; Justin Pollara; Mangala Rao; Kristina K Peachman; Sampa Santra; Norman L Letvin; Nicos Karasavvas; Zhi-Yong Yang; Kaifan Dai; Marie Pancera; Jason Gorman; Kevin Wiehe; Nathan I Nicely; Supachai Rerks-Ngarm; Sorachai Nitayaphan; Jaranit Kaewkungwal; Punnee Pitisuttithum; James Tartaglia; Faruk Sinangil; Jerome H Kim; Nelson L Michael; Thomas B Kepler; Peter D Kwong; John R Mascola; Gary J Nabel; Abraham Pinter; Susan Zolla-Pazner; Barton F Haynes
Journal:  Immunity       Date:  2013-01-11       Impact factor: 31.745

7.  The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.

Authors:  Christopher N Scanlan; Ralph Pantophlet; Mark R Wormald; Erica Ollmann Saphire; Robyn Stanfield; Ian A Wilson; Hermann Katinger; Raymond A Dwek; Pauline M Rudd; Dennis R Burton
Journal:  J Virol       Date:  2002-07       Impact factor: 5.103

Review 8.  Antiviral antibody responses: the two extremes of a wide spectrum.

Authors:  Lars Hangartner; Rolf M Zinkernagel; Hans Hengartner
Journal:  Nat Rev Immunol       Date:  2006-03       Impact factor: 53.106

9.  A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies.

Authors:  Rogier W Sanders; Ronald Derking; Albert Cupo; Jean-Philippe Julien; Anila Yasmeen; Natalia de Val; Helen J Kim; Claudia Blattner; Alba Torrents de la Peña; Jacob Korzun; Michael Golabek; Kevin de Los Reyes; Thomas J Ketas; Marit J van Gils; C Richter King; Ian A Wilson; Andrew B Ward; P J Klasse; John P Moore
Journal:  PLoS Pathog       Date:  2013-09-19       Impact factor: 6.823

10.  Reconstructing a B-cell clonal lineage. I. Statistical inference of unobserved ancestors.

Authors:  Thomas B Kepler
Journal:  F1000Res       Date:  2013-04-03
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  42 in total

Review 1.  How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design.

Authors:  Marie Pancera; Anita Changela; Peter D Kwong
Journal:  Curr Opin HIV AIDS       Date:  2017-05       Impact factor: 4.283

Review 2.  Multi-Envelope HIV-1 Vaccine Development: Two Targeted Immune Pathways, One Desired Protective Outcome.

Authors:  Julia L Hurwitz; Mattia Bonsignori
Journal:  Viral Immunol       Date:  2018-01-09       Impact factor: 2.257

Review 3.  Targeting the N332-supersite of the HIV-1 envelope for vaccine design.

Authors:  Thandeka Moyo; Dale Kitchin; Penny L Moore
Journal:  Expert Opin Ther Targets       Date:  2020-04-27       Impact factor: 6.902

4.  Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates.

Authors:  Kevin O Saunders; Nathan I Nicely; Kevin Wiehe; Mattia Bonsignori; R Ryan Meyerhoff; Robert Parks; William E Walkowicz; Baptiste Aussedat; Nelson R Wu; Fangping Cai; Yusuf Vohra; Peter K Park; Amanda Eaton; Eden P Go; Laura L Sutherland; Richard M Scearce; Dan H Barouch; Ruijun Zhang; Tarra Von Holle; R Glenn Overman; Kara Anasti; Rogier W Sanders; M Anthony Moody; Thomas B Kepler; Bette Korber; Heather Desaire; Sampa Santra; Norman L Letvin; Gary J Nabel; David C Montefiori; Georgia D Tomaras; Hua-Xin Liao; S Munir Alam; Samuel J Danishefsky; Barton F Haynes
Journal:  Cell Rep       Date:  2017-02-28       Impact factor: 9.423

5.  Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models.

Authors:  Kevin O Saunders; Laurent K Verkoczy; Chuancang Jiang; Jinsong Zhang; Robert Parks; Haiyan Chen; Max Housman; Hilary Bouton-Verville; Xiaoying Shen; Ashley M Trama; Richard Scearce; Laura Sutherland; Sampa Santra; Amanda Newman; Amanda Eaton; Kai Xu; Ivelin S Georgiev; M Gordon Joyce; Georgia D Tomaras; Mattia Bonsignori; Steven G Reed; Andres Salazar; John R Mascola; M Anthony Moody; Derek W Cain; Mireille Centlivre; Sandra Zurawski; Gerard Zurawski; Harold P Erickson; Peter D Kwong; S Munir Alam; Yves Levy; David C Montefiori; Barton F Haynes
Journal:  Cell Rep       Date:  2017-12-26       Impact factor: 9.423

6.  Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.

Authors:  Rui Kong; Hongying Duan; Zizhang Sheng; Kai Xu; Priyamvada Acharya; Xuejun Chen; Cheng Cheng; Adam S Dingens; Jason Gorman; Mallika Sastry; Chen-Hsiang Shen; Baoshan Zhang; Tongqing Zhou; Gwo-Yu Chuang; Cara W Chao; Ying Gu; Alexander J Jafari; Mark K Louder; Sijy O'Dell; Ariana P Rowshan; Elise G Viox; Yiran Wang; Chang W Choi; Martin M Corcoran; Angela R Corrigan; Venkata P Dandey; Edward T Eng; Hui Geng; Kathryn E Foulds; Yicheng Guo; Young D Kwon; Bob Lin; Kevin Liu; Rosemarie D Mason; Martha C Nason; Tiffany Y Ohr; Li Ou; Reda Rawi; Edward K Sarfo; Arne Schön; John P Todd; Shuishu Wang; Hui Wei; Winston Wu; James C Mullikin; Robert T Bailer; Nicole A Doria-Rose; Gunilla B Karlsson Hedestam; Diana G Scorpio; Julie Overbaugh; Jesse D Bloom; Bridget Carragher; Clinton S Potter; Lawrence Shapiro; Peter D Kwong; John R Mascola
Journal:  Cell       Date:  2019-07-25       Impact factor: 41.582

7.  Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

Authors:  Mattia Bonsignori; Edward F Kreider; Daniela Fera; R Ryan Meyerhoff; Todd Bradley; Kevin Wiehe; S Munir Alam; Baptiste Aussedat; William E Walkowicz; Kwan-Ki Hwang; Kevin O Saunders; Ruijun Zhang; Morgan A Gladden; Anthony Monroe; Amit Kumar; Shi-Mao Xia; Melissa Cooper; Mark K Louder; Krisha McKee; Robert T Bailer; Brendan W Pier; Claudia A Jette; Garnett Kelsoe; Wilton B Williams; Lynn Morris; John Kappes; Kshitij Wagh; Gift Kamanga; Myron S Cohen; Peter T Hraber; David C Montefiori; Ashley Trama; Hua-Xin Liao; Thomas B Kepler; M Anthony Moody; Feng Gao; Samuel J Danishefsky; John R Mascola; George M Shaw; Beatrice H Hahn; Stephen C Harrison; Bette T Korber; Barton F Haynes
Journal:  Sci Transl Med       Date:  2017-03-15       Impact factor: 17.956

Review 8.  Structural Insights from HIV-Antibody Coevolution and Related Immunization Studies.

Authors:  Jeffrey O Zhou; Therese Ton; Julia W Morriss; Diep Nguyen; Daniela Fera
Journal:  AIDS Res Hum Retroviruses       Date:  2018-08-15       Impact factor: 2.205

9.  Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies.

Authors:  Hui Cai; Jared Orwenyo; Javier Guenaga; John Giddens; Christian Toonstra; Richard T Wyatt; Lai-Xi Wang
Journal:  Chem Commun (Camb)       Date:  2017-05-03       Impact factor: 6.222

10.  Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses.

Authors:  Hui Cai; Jared Orwenyo; John P Giddens; Qiang Yang; Roushu Zhang; Celia C LaBranche; David C Montefiori; Lai-Xi Wang
Journal:  Cell Chem Biol       Date:  2017-10-26       Impact factor: 8.116
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