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Literature DB >> 2828660

Specific amino acid substitutions are not required for transformation by v-myb of avian myeloblastosis virus.

Abstract

The protein product of the v-myb oncogene of avian myeloblastosis virus, p48v-myb, differs structurally in several ways from its normal cellular homolog, p75c-myb. We demonstrated that the 11 specific amino acid substitutions found in two independent molecular clones of this virus were not required for the transformation of myeloblasts by v-myb.

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Year: 1988 PMID： 2828660 PMCID： PMC253675 DOI： 10.1128/JVI.62.3.1093-1096.1988

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

25 in total

Review 1. The myb oncogene.

Authors: J S Lipsick; M A Baluda
Journal: Gene Amplif Anal Date: 1986

2. c-myb protein expression is a late event during T-lymphocyte activation.

Authors: J S Lipsick; W J Boyle
Journal: Mol Cell Biol Date: 1987-09 Impact factor: 4.272

3. Mechanism of activation of a human oncogene.

Authors: C J Tabin; S M Bradley; C I Bargmann; R A Weinberg; A G Papageorge; E M Scolnick; R Dhar; D R Lowy; E H Chang
Journal: Nature Date: 1982-11-11 Impact factor: 49.962

4. Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene.

Authors: K H Klempnauer; T J Gonda; J M Bishop
Journal: Cell Date: 1982-12 Impact factor: 41.582

5. Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue.

Authors: D J Capon; E Y Chen; A D Levinson; P H Seeburg; D V Goeddel
Journal: Nature Date: 1983-03-03 Impact factor: 49.962

6. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene.

Authors: E P Reddy; R K Reynolds; E Santos; M Barbacid
Journal: Nature Date: 1982-11-11 Impact factor: 49.962

7. Overexpression of an alternatively spliced form of c-Myb results in increases in transactivation and transforms avian myelomonoblasts.

Authors: C H Woo; L Sopchak; J S Lipsick
Journal: J Virol Date: 1998-08 Impact factor: 5.103

8. Oncogenic truncation of the first repeat of c-Myb decreases DNA binding in vitro and in vivo.

Authors: P W Dini; J S Lipsick
Journal: Mol Cell Biol Date: 1993-12 Impact factor: 4.272

9. Activation of c-myb by carboxy-terminal truncation: relationship to transformation of murine haemopoietic cells in vitro.

Authors: T J Gonda; C Buckmaster; R G Ramsay
Journal: EMBO J Date: 1989-06 Impact factor: 11.598

9 in total

Specific amino acid substitutions are not required for transformation by v-myb of avian myeloblastosis virus.

Review 1. The myb oncogene.

2. c-myb protein expression is a late event during T-lymphocyte activation.

3. Mechanism of activation of a human oncogene.

4. Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene.

5. Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue.

6. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene.

7. Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change.

8. Endogenous avian retroviruses contain deficient promoter and leader sequences.

9. Differential expression of the amv gene in human hematopoietic cells.

10. Transforming activity of polyoma virus middle-T antigen probed by site-directed mutagenesis.

1. Protein truncation is required for the activation of the c-myb proto-oncogene.

2. Reduction of a conserved Cys is essential for Myb DNA-binding.

3. Structural organization of upstream exons and distribution of transcription start sites in the chicken c-myb gene.

4. Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation.

5. Individual repeats of Drosophila Myb can function in transformation by v-Myb.

6. The carboxyterminus of human c-myb protein stimulates activated transcription in trans.

7. Overexpression of an alternatively spliced form of c-Myb results in increases in transactivation and transforms avian myelomonoblasts.

8. Oncogenic truncation of the first repeat of c-Myb decreases DNA binding in vitro and in vivo.

9. Activation of c-myb by carboxy-terminal truncation: relationship to transformation of murine haemopoietic cells in vitro.