Y-C Chen1,2, A-H Chih3,4, J-R Chen2, T-H Liou5, W-H Pan6, Y L Lee3,6. 1. Taipei City Hospital, ZhongXing Branch, Taipei, Taiwan. 2. School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan. 3. Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. 4. Health Center, Office of Student Affairs, National Taiwan University, Taipei, Taiwan. 5. Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei, Taiwan. 6. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Abstract
BACKGROUND/ OBJECTIVES: We aim to (1) examine the influence of long-term adiposity status/short-term adiposity changes on asthma with high or low fractional exhaled nitric oxide (FeNO), and (2) to determine the differences in long-term adiposity status/short-term adiposity changes on atopy, airway inflammation and pulmonary function. SUBJECTS/ METHODS: We recruited 2450 fourth- to sixth-grade children from the nationwide Taiwan Children Health Study. Data regarding various adiposity indicators, atopic status, pulmonary function tests and asthma outcomes were collected annually. New-onset asthma was stratified by airway inflammation status using FeNO. The generalized estimating equation was used for analyzing longitudinal relationships between long-term adiposity status/short-term adiposity changes and new-onset asthma. Individual adiposity growth slopes were obtained using a hierarchical linear model to establish the relationships between short-term adiposity changes and asthma among children with high airway inflammation. RESULTS: We found long-term adiposity status predicted childhood asthma with low FeNO, whereas short-term adiposity changes may increase risks of childhood asthma with high FeNO. Long-term adiposity status reduced pulmonary function, whereas short-term adiposity increase were associated with atopic diseases and airway inflammation. CONCLUSIONS: Obesity-induced asthma could be mediated by high or low airway inflammation, depending on the velocity of increase in adiposity. Rapid adiposity growth may increase risks of childhood asthma and airway inflammation.
BACKGROUND/ OBJECTIVES: We aim to (1) examine the influence of long-term adiposity status/short-term adiposity changes on asthma with high or low fractional exhaled nitric oxide (FeNO), and (2) to determine the differences in long-term adiposity status/short-term adiposity changes on atopy, airway inflammation and pulmonary function. SUBJECTS/ METHODS: We recruited 2450 fourth- to sixth-grade children from the nationwide Taiwan Children Health Study. Data regarding various adiposity indicators, atopic status, pulmonary function tests and asthma outcomes were collected annually. New-onset asthma was stratified by airway inflammation status using FeNO. The generalized estimating equation was used for analyzing longitudinal relationships between long-term adiposity status/short-term adiposity changes and new-onset asthma. Individual adiposity growth slopes were obtained using a hierarchical linear model to establish the relationships between short-term adiposity changes and asthma among children with high airway inflammation. RESULTS: We found long-term adiposity status predicted childhood asthma with low FeNO, whereas short-term adiposity changes may increase risks of childhood asthma with high FeNO. Long-term adiposity status reduced pulmonary function, whereas short-term adiposity increase were associated with atopic diseases and airway inflammation. CONCLUSIONS: Obesity-induced asthma could be mediated by high or low airway inflammation, depending on the velocity of increase in adiposity. Rapid adiposity growth may increase risks of childhood asthma and airway inflammation.
Authors: Frank D Gilliland; Kiros Berhane; Talat Islam; Rob McConnell; W James Gauderman; Susan S Gilliland; Edward Avol; John M Peters Journal: Am J Epidemiol Date: 2003-09-01 Impact factor: 4.897
Authors: Katharine C Pike; Sarah R Crozier; Jane S A Lucas; Hazel M Inskip; Sian Robinson; Graham Roberts; Keith M Godfrey Journal: Thorax Date: 2010-10-18 Impact factor: 9.139
Authors: Stephanie Lovinsky-Desir; Stephanie J Lussier; Agustin Calatroni; Peter J Gergen; Katherine Rivera-Spoljaric; Leonard B Bacharier; Aliva De; George T O'Connor; Megan T Sandel; Robert A Wood; Emilio Arteaga-Solis; James E Gern; Meyer Kattan Journal: J Allergy Clin Immunol Date: 2021-06-22 Impact factor: 10.793