Stephanie Lovinsky-Desir1, Stephanie J Lussier2, Agustin Calatroni2, Peter J Gergen3, Katherine Rivera-Spoljaric4, Leonard B Bacharier4, Aliva De5, George T O'Connor6, Megan T Sandel6, Robert A Wood7, Emilio Arteaga-Solis5, James E Gern8, Meyer Kattan5. 1. Division of Pediatric Pulmonology, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY. Electronic address: sl3230@cumc.columbia.edu. 2. Rho Inc, Federal Research Operations, Durham, NC. 3. National Institute of Allergy and Infectious Diseases, Rockville, Md. 4. Department of Pediatrics, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Mo. 5. Division of Pediatric Pulmonology, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY. 6. Department of Medicine, Boston University School of Medicine, Boston, Mass. 7. Department of Pediatrics, Johns Hopkins University Medical Center, Baltimore, Md. 8. Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis.
Abstract
BACKGROUND: A relationship between adiposity and asthma has been described in some cohort studies, but little is known about trajectories of adiposity throughout early childhood among children at high risk for developing asthma in urban United States cities. Moreover, early life trajectories of adipokines that have metabolic and immunologic properties have not been comprehensively investigated. OBJECTIVE: Our objective was to characterize trajectories of adiposity in a longitudinal birth cohort of predominately Black and Latinx children (n = 418) using several different repeated measures including body mass index (BMI) z score, bioimpedance analysis, leptin, and adiponectin in the first 10 years of life. METHODS: In a longitudinal birth cohort of predominately Black and Latinx children, we used repeated annual measures of BMI, bioimpedance analysis (ie, percentage of body fat), leptin, and adiponectin to create trajectories across the first 10 years of life. Across those trajectories, we compared asthma diagnosis and multiple lung function outcomes, including spirometry, impulse oscillometry, and methacholine response. RESULTS: Three trajectories were observed for BMI z score, bioimpedance analysis, and leptin and 2 for adiponectin. There was no association between trajectories of BMI, percentage of body fat, leptin, or adipokine and asthma diagnosis or lung function (P > .05). CONCLUSIONS: Trajectories of adiposity were not associated with asthma or lung function in children at high risk for developing asthma. Risk factors related to geography as well as social and demographic factors unique to specific populations could explain the lack of association and should be considered in obesity and asthma studies.
BACKGROUND: A relationship between adiposity and asthma has been described in some cohort studies, but little is known about trajectories of adiposity throughout early childhood among children at high risk for developing asthma in urban United States cities. Moreover, early life trajectories of adipokines that have metabolic and immunologic properties have not been comprehensively investigated. OBJECTIVE: Our objective was to characterize trajectories of adiposity in a longitudinal birth cohort of predominately Black and Latinx children (n = 418) using several different repeated measures including body mass index (BMI) z score, bioimpedance analysis, leptin, and adiponectin in the first 10 years of life. METHODS: In a longitudinal birth cohort of predominately Black and Latinx children, we used repeated annual measures of BMI, bioimpedance analysis (ie, percentage of body fat), leptin, and adiponectin to create trajectories across the first 10 years of life. Across those trajectories, we compared asthma diagnosis and multiple lung function outcomes, including spirometry, impulse oscillometry, and methacholine response. RESULTS: Three trajectories were observed for BMI z score, bioimpedance analysis, and leptin and 2 for adiponectin. There was no association between trajectories of BMI, percentage of body fat, leptin, or adipokine and asthma diagnosis or lung function (P > .05). CONCLUSIONS: Trajectories of adiposity were not associated with asthma or lung function in children at high risk for developing asthma. Risk factors related to geography as well as social and demographic factors unique to specific populations could explain the lack of association and should be considered in obesity and asthma studies.
Authors: Herman T den Dekker; Karen P I Ros; Johan C de Jongste; Irwin K Reiss; Vincent W Jaddoe; Liesbeth Duijts Journal: J Allergy Clin Immunol Date: 2016-07-16 Impact factor: 10.793
Authors: Meyer Kattan; Rajesh Kumar; Gordon R Bloomberg; Herman E Mitchell; Agustin Calatroni; Peter J Gergen; Carolyn M Kercsmar; Cynthia M Visness; Elizabeth C Matsui; Suzanne F Steinbach; Stanley J Szefler; Christine A Sorkness; Wayne J Morgan; Stephen J Teach; Vanthaya N Gan Journal: J Allergy Clin Immunol Date: 2010-03 Impact factor: 10.793
Authors: T Jartti; L Saarikoski; L Jartti; I Lisinen; A Jula; R Huupponen; J Viikari; O T Raitakari Journal: Allergy Date: 2009-02-11 Impact factor: 13.146
Authors: Hannah Lennon; Scott Kelly; Matthew Sperrin; Iain Buchan; Amanda J Cross; Michael Leitzmann; Michael B Cook; Andrew G Renehan Journal: BMJ Open Date: 2018-07-07 Impact factor: 2.692
Authors: Leonard B Bacharier; Avraham Beigelman; Agustin Calatroni; Daniel J Jackson; Peter J Gergen; George T O'Connor; Meyer Kattan; Robert A Wood; Megan T Sandel; Susan V Lynch; Kei E Fujimura; Douglas W Fadrosh; Clark A Santee; Homer Boushey; Cynthia M Visness; James E Gern Journal: Am J Respir Crit Care Med Date: 2019-01-01 Impact factor: 30.528
Authors: Ali H Ziyab; Wilfried Karmaus; Ramesh J Kurukulaaratchy; Hongmei Zhang; Syed Hasan Arshad Journal: J Epidemiol Community Health Date: 2014-06-03 Impact factor: 3.710
Authors: Erick Forno; Diego D Brandenburg; Jose A Castro-Rodriguez; Carlos A Celis-Preciado; Fernando Holguin; Christopher Licskai; Stephanie Lovinsky-Desir; Marcia Pizzichini; Alejandro Teper; Connie Yang; Juan C Celedón Journal: Ann Am Thorac Soc Date: 2022-04