R J Waken1, Lisa de Las Fuentes2,3, D C Rao2. 1. Division of Biostatistics, Washington University in St. Louis, School of Medicine, 660 S. Euclid Ave, Campus Box 8067, St. Louis, MO, 63110, USA. rjwaken@wustl.edu. 2. Division of Biostatistics, Washington University in St. Louis, School of Medicine, 660 S. Euclid Ave, Campus Box 8067, St. Louis, MO, 63110, USA. 3. Division of Cardiology, Department of Medicine, 660 S. Euclid Ave, Campus Box 8086, St. Louis, MO, 63110, USA.
Abstract
PURPOSE OF REVIEW: Here, we discuss the interpretation and modeling of gene-environment interactions in hypertension-related phenotypes, with a focus on the necessary assumptions and possible challenges. RECENT FINDINGS: Recently, small cohort studies have discovered several novel genetic variants associated with hypertension-related phenotypes through modeling gene-environment interactions. Several consortia-based meta-analytic efforts have uncovered many novel genetic variants in hypertension without modeling interaction terms, giving promise to future meta-analytic efforts that incorporate gene-environment interactions. Heritability studies and genome-wide association studies have established that hypertension, a prevalent cardiovascular disease, has a genetic component that may be modulated by the environment (such as lifestyle factors). This review includes a discussion of known genetic associations for hypertension/blood pressure, including those resulting from the incorporation of gene-environmental interaction modeling.
PURPOSE OF REVIEW: Here, we discuss the interpretation and modeling of gene-environment interactions in hypertension-related phenotypes, with a focus on the necessary assumptions and possible challenges. RECENT FINDINGS: Recently, small cohort studies have discovered several novel genetic variants associated with hypertension-related phenotypes through modeling gene-environment interactions. Several consortia-based meta-analytic efforts have uncovered many novel genetic variants in hypertension without modeling interaction terms, giving promise to future meta-analytic efforts that incorporate gene-environment interactions. Heritability studies and genome-wide association studies have established that hypertension, a prevalent cardiovascular disease, has a genetic component that may be modulated by the environment (such as lifestyle factors). This review includes a discussion of known genetic associations for hypertension/blood pressure, including those resulting from the incorporation of gene-environmental interaction modeling.
Entities:
Keywords:
Cardiovascular disease; Gene-environment; Genetics of hypertension; Phenotypes
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