Literature DB >> 28277089

Injecting rabies immunoglobulin (RIG) into wounds only: A significant saving of lives and costly RIG.

Omesh Kumar Bharti1, Shampur Narayan Madhusudana2, Henry Wilde3.   

Abstract

An increasing number of dog bite victims were being presented to public hospitals in Himachal Pradesh in 2014 amidst virtual non availability of any rabies immunoglobulin (RIG). Only a small quantity of equine rabies immunoglobulin (eRIG) was available from the government owned Central Research Institute (CRI) Kasauli. This available eRIG was used in 269 patients as an emergency response and only for local infiltration of severe bite wounds by suspected rabid dogs. This was followed by rabies vaccination, using the WHO approved intra-dermal Thai Red Cross Society vaccination schedule. A subgroup of 26 patients were later identified who had been severely bitten by laboratory confirmed rabid dogs. They were followed for more than one year and all were found to be alive.

Entities:  

Keywords:  Rabies; Rabies immunoglobulin; animal bites; post-exposure prophylaxis; wound injection

Mesh：

Substances：

Year:  2017        PMID： 28277089      PMCID： PMC5404375          DOI： 10.1080/21645515.2016.1255834

Source DB:  PubMed          Journal:  Hum Vaccin Immunother        ISSN： 2164-5515            Impact factor:   3.452


  13 in total

1.  Studies on the local treatment of rabies-infected wounds.

Authors:  D J DEAN; G M BAER; W R THOMPSON
Journal:  Bull World Health Organ       Date:  1963       Impact factor: 9.408

2.  Local infiltration of rabies immunoglobulins without systemic intramuscular administration: An alternative cost effective approach for passive immunization against rabies.

Authors:  Omesh Kumar Bharti; Shampur Narayan Madhusudana; Pyare Lal Gaunta; Ashwin Yajaman Belludi
Journal:  Hum Vaccin Immunother       Date:  2016-03-03       Impact factor: 3.452

3.  Failures of post-exposure rabies prophylaxis.

Authors:  Henry Wilde
Journal:  Vaccine       Date:  2007-09-14       Impact factor: 3.641

4.  Evaluation of the safety, immunogenicity, and pharmacokinetic profile of a new, highly purified, heat-treated equine rabies immunoglobulin, administered either alone or in association with a purified, Vero-cell rabies vaccine.

Authors:  J Lang; P Attanath; B Quiambao; V Singhasivanon; P Chanthavanich; C Montalban; C Lutsch; S Pepin-Covatta; V Le Mener; M Miranda; A Sabchareon
Journal:  Acta Trop       Date:  1998-07-30       Impact factor: 3.112

5.  Worldwide rabies deaths prevention--A focus on the current inadequacies in postexposure prophylaxis of animal bite victims.

Authors:  Henry Wilde; Boonlert Lumlertdacha; François X Meslin; Siriporn Ghai; Thiravat Hemachudha
Journal:  Vaccine       Date:  2015-11-25       Impact factor: 3.641

6.  Feasibility of reducing rabies immunoglobulin dosage for passive immunization against rabies: results of In vitro and In vivo studies.

Authors:  Shampur Narayan Madhusudana; Belludi Yajaman Ashwin; Sampada Sudarshan
Journal:  Hum Vaccin Immunother       Date:  2013-06-21       Impact factor: 3.452

7.  A 4‐site, single‐visit intradermal postexposure prophylaxis regimen for previously vaccinated patients: experiences with >5000 patients.

Authors:  Prapimporn Shantavasinkul; Terapong Tantawichien; Wipaporn Jaijaroensup; Samran Lertjarutorn; Ampai Banjongkasaena; Henry Wilde; Visith Sitprija
Journal:  Clin Infect Dis       Date:  2010-11-01       Impact factor: 9.079

8.  Assessing the burden of human rabies in India: results of a national multi-center epidemiological survey.

Authors:  M K Sudarshan; S N Madhusudana; B J Mahendra; N S N Rao; D H Ashwath Narayana; S Abdul Rahman; F -X Meslin; D Lobo; K Ravikumar
Journal:  Int J Infect Dis       Date:  2006-05-04       Impact factor: 3.623

9.  Failure of postexposure treatment of rabies in children.

Authors:  H Wilde; S Sirikawin; A Sabcharoen; D Kingnate; T Tantawichien; P A Harischandra; N Chaiyabutr; D G de Silva; L Fernando; J B Liyanage; V Sitprija
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Authors:  Thiravat Hemachudha; Gabriella Ugolini; Supaporn Wacharapluesadee; Witaya Sungkarat; Shanop Shuangshoti; Jiraporn Laothamatas
Journal:  Lancet Neurol       Date:  2013-05       Impact factor: 44.182
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  11 in total

1.  Failure of postexposure prophylaxis in a girl child attacked by rabid dog severing her facial nerve causing possible direct entry of rabies virus into the facial nerve.

Authors:  Omesh Kumar Bharti; Daleep Tekta; Ambuj Shandil; Kalpana Sharma; Piyush Kapila
Journal:  Hum Vaccin Immunother       Date:  2019-05-22       Impact factor: 3.452

2.  Implementation of Clinical Decision Support on Emergency Department Delivery of Human Rabies Immune Globulin.

Authors:  Fangzheng Yuan; Tomona Iso; Elsie Rizk; R Benjamin Saldana; Anh Thu Tran; Ngoc-Anh A Nguyen; Prasanth R Boyareddigari; Daniela Espino; Joshua T Swan
Journal:  JAMA Netw Open       Date:  2022-06-01

3.  Defining the volume of rabies immunoglobulins/ rabies monoclonal antibodies requirement for wound infiltration of category III animal exposures - an exploratory study.

Authors:  Ravish S Haradanhalli; Nitu Kumari; Mysore K Sudarshan; D H Ashwath Narayana; Ramya M Prashanth; Jithin Surendran
Journal:  Hum Vaccin Immunother       Date:  2022-01-21       Impact factor: 3.452

Review 4.  Plasma therapy: a passive resistance against the deadliest.

Authors:  Anita Hansda; Debarati Biswas; Aishwarya Bhatta; Nishant Chakravorty; Gayatri Mukherjee
Journal:  Hum Vaccin Immunother       Date:  2021-12-09       Impact factor: 4.526

5.  Adherence to guideline recommendations for human rabies immune globulin patient selection, dosing, timing, and anatomical site of administration in rabies postexposure prophylaxis.

Authors:  Grace S Hwang; Elsie Rizk; Lan N Bui; Tomona Iso; Emily I Sartain; Anh Thu Tran; Joshua T Swan
Journal:  Hum Vaccin Immunother       Date:  2019-08-01       Impact factor: 3.452

6.  Modelling to inform prophylaxis regimens to prevent human rabies.

Authors:  Katie Hampson; Bernadette Abela-Ridder; Omesh Bharti; Lea Knopf; Monique Léchenne; Rolande Mindekem; Arnaud Tarantola; Jakob Zinsstag; Caroline Trotter
Journal:  Vaccine       Date:  2018-12-07       Impact factor: 4.169

7.  Rabies encephalitis in a preschool child following postexposure prophylaxis.

Authors:  K M Chaitra; Sandeep Ballal; N R Ramesh Masthi; D H Ashwath Narayana; H T Yashodha; Mansi Kumar; Afroza Asiya; Divya Bharathi G; Sanjay S C
Journal:  PLoS Negl Trop Dis       Date:  2021-02-18

8.  Determining the post-elimination level of vaccination needed to prevent re-establishment of dog rabies.

Authors:  Seonghye Jeon; Julie Cleaton; Martin I Meltzer; Emily B Kahn; Emily G Pieracci; Jesse D Blanton; Ryan Wallace
Journal:  PLoS Negl Trop Dis       Date:  2019-12-02

9.  Rabies vaccination strategies in the Netherlands in 2018: a cost evaluation.

Authors:  Anita Wm Suijkerbuijk; Marie-Josee J Mangen; Manon R Haverkate; Floriana S Luppino; Sabine E Bantjes; Leo G Visser; Corien M Swaan; Wilhelmina Lm Ruijs; Eelco Ab Over
Journal:  Euro Surveill       Date:  2020-09

10.  Abandon of intramuscular administration of rabies immunoglobulin for post-exposure prophylaxis in the revised guidelines in the Netherlands in 2018: cost and volume savings.

Authors:  Imke Schreuder; Cornelis De Pijper; Rob van Kessel; Leo Visser; Hans van den Kerkhof
Journal:  Euro Surveill       Date:  2020-09
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