Literature DB >> 31035833

Failure of postexposure prophylaxis in a girl child attacked by rabid dog severing her facial nerve causing possible direct entry of rabies virus into the facial nerve.

Omesh Kumar Bharti1, Daleep Tekta2, Ambuj Shandil3, Kalpana Sharma4, Piyush Kapila5.   

Abstract

On January 4, 2019 an eight-year-old girl child was bitten by a suspected rabid dog over the left parotid region. After a 17-h delay, the child was brought for rabies postexposure prophylaxis (PEP) at Civil Hospital Theog and was administered complete PEP. On January 29, 2019, the child was again brought to Theog Hospital with complaints of having fever, difficulty in walking, neck drop, and ptosis. On examination, pediatrician found photophobia, phonophobia, and hydrophobia and subsequently the patient died of cardiac arrest. On postmortem examination, the facial nerve was found dissected and injured at the inner end of the parotid gland. A severed end toward the brain was swollen and edematous. The entire brain was extracted and sent to Central Research Institute Kasauli for confirmation of rabies, where it tested positive for rabies by Fluorescent Antibodies Test and Biological Test. In situations where sensitive parts such as the face are involved, a thorough wound wash with soap and water and application of antiseptics along with immediate PEP may save some lives by not allowing the virus enough time to attach to and infect the nerve cells.

Entities:  

Keywords:  PEP failure; Rabies; facial nerve; rabies virus

Mesh:

Year:  2019        PMID: 31035833      PMCID: PMC6930059          DOI: 10.1080/21645515.2019.1608131

Source DB:  PubMed          Journal:  Hum Vaccin Immunother        ISSN: 2164-5515            Impact factor:   3.452


  11 in total

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Journal:  Hum Vaccin Immunother       Date:  2016-03-03       Impact factor: 3.452

2.  Failures of post-exposure rabies prophylaxis.

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Review 3.  Rabies.

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4.  Rabies encephalitis in a child: a failure of rabies post exposure prophylaxis?

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Journal:  BMJ Case Rep       Date:  2015-01-14

5.  Injecting rabies immunoglobulin (RIG) into wounds only: A significant saving of lives and costly RIG.

Authors:  Omesh Kumar Bharti; Shampur Narayan Madhusudana; Henry Wilde
Journal:  Hum Vaccin Immunother       Date:  2017-02-22       Impact factor: 3.452

6.  Direct entry of rabies virus into the central nervous system without prior local replication.

Authors:  V Shankar; B Dietzschold; H Koprowski
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Journal:  PLoS Negl Trop Dis       Date:  2015-05-11

Review 8.  Pre-exposure rabies prophylaxis: a systematic review.

Authors:  Jocelyn A Kessels; Sergio Recuenco; Ana Maria Navarro-Vela; Raffy Deray; Marco Vigilato; Hildegund Ertl; David Durrheim; Helen Rees; Louis H Nel; Bernadette Abela-Ridder; Deborah Briggs
Journal:  Bull World Health Organ       Date:  2016-11-25       Impact factor: 9.408

9.  "Scratches/Abrasions without Bleeding" Cause Rabies: A 7 Years Rabies Death Review from Medical College Shimla, Himachal Pradesh, India.

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10.  Modelling to inform prophylaxis regimens to prevent human rabies.

Authors:  Katie Hampson; Bernadette Abela-Ridder; Omesh Bharti; Lea Knopf; Monique Léchenne; Rolande Mindekem; Arnaud Tarantola; Jakob Zinsstag; Caroline Trotter
Journal:  Vaccine       Date:  2018-12-07       Impact factor: 4.169

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  2 in total

Review 1.  Time to Revise the WHO Categories for Severe Rabies Virus Exposures-Category IV?

Authors:  Stephen J Scholand; Beatriz P Quiambao; Charles E Rupprecht
Journal:  Viruses       Date:  2022-05-22       Impact factor: 5.818

2.  Clinical, epidemiological, and spatial features of human rabies cases in Metro Manila, the Philippines from 2006 to 2015.

Authors:  Ferdinand D Guzman; Yuta Iwamoto; Nobuo Saito; Eumelia P Salva; Efren M Dimaano; Akira Nishizono; Motoi Suzuki; Oladeji Oloko; Koya Ariyoshi; Chris Smith; Christopher M Parry; Rontgene M Solante
Journal:  PLoS Negl Trop Dis       Date:  2022-07-19
  2 in total

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