Tanguy Blaire1,2,3, Alban Bailliez4,5,6, Fayçal Ben Bouallegue7, Dimitri Bellevre8, Denis Agostini5,8, Alain Manrique5,8. 1. Department of Nuclear Medicine, UF 5881, Groupement des Hôpitaux de l'Institut Catholique de Lille, Lomme, France. ta.blaire@gmail.com. 2. Normandie Univ, UNICAEN, Signalisation, électrophysiologie et imagerie des lésions d'ischémie-reperfusion myocardique, FHU REMOD-VHF, 14000, Caen, France. ta.blaire@gmail.com. 3. Department of Nuclear Medicine, IRIS, Hôpital Privé Le Bois, Lille, France. ta.blaire@gmail.com. 4. Department of Nuclear Medicine, UF 5881, Groupement des Hôpitaux de l'Institut Catholique de Lille, Lomme, France. 5. Normandie Univ, UNICAEN, Signalisation, électrophysiologie et imagerie des lésions d'ischémie-reperfusion myocardique, FHU REMOD-VHF, 14000, Caen, France. 6. Department of Nuclear Medicine, IRIS, Hôpital Privé Le Bois, Lille, France. 7. Department of Nuclear Medicine, CHU de Montpellier, Montpellier, France. 8. Department of Nuclear Medicine, CHU Cote de Nacre, Caen, France.
Abstract
BACKGROUND: We studied the impact of simultaneous dual-isotope acquisition on 123I/99mTc mismatch assessment using two CZT cameras (DNM 530c, GE Healthcare and DSPECT, Biosensors International). METHODS: We used an anthropomorphic torso phantom (respectively filled with a solution of 123I alone, 99mTc alone, and a mixture of 123I and 99mTc) and its cardiac insert with two defects mimicking two matched and mismatched defects. Mismatch extent and reconstructed image contrast were evaluated. RESULTS: The acquisition mode (single vs dual) significantly impacted (i) 99mTc (but not 123I) reconstructed segmental activities using both camera (P < .001), and (ii) image contrast (using 123I and DNM 530c, P < .0001; and using both 123I and 99mTc with DSPECT, P < .0001). However, the defect and mismatch size were not impacted by the type of acquisition. With both DNM 530c and DSPECT, Lin's concordance correlation coefficient and Bland-Altman analysis demonstrated an almost perfect concordance and agreement between single- and simultaneous dual-isotope segmental activity (123I and 99mTc). CONCLUSIONS: This study found no impact of the acquisition mode (single vs dual) or the type of camera (DSPECT vs DNM 530c) on 123I and 99mTc defect size and mismatch, providing a new step toward simultaneous dual-isotope acquisition for combined innervation and perfusion assessment.
BACKGROUND: We studied the impact of simultaneous dual-isotope acquisition on 123I/99mTc mismatch assessment using two CZT cameras (DNM 530c, GE Healthcare and DSPECT, Biosensors International). METHODS: We used an anthropomorphic torso phantom (respectively filled with a solution of 123I alone, 99mTc alone, and a mixture of 123I and 99mTc) and its cardiac insert with two defects mimicking two matched and mismatched defects. Mismatch extent and reconstructed image contrast were evaluated. RESULTS: The acquisition mode (single vs dual) significantly impacted (i) 99mTc (but not 123I) reconstructed segmental activities using both camera (P < .001), and (ii) image contrast (using 123I and DNM 530c, P < .0001; and using both 123I and 99mTc with DSPECT, P < .0001). However, the defect and mismatch size were not impacted by the type of acquisition. With both DNM 530c and DSPECT, Lin's concordance correlation coefficient and Bland-Altman analysis demonstrated an almost perfect concordance and agreement between single- and simultaneous dual-isotope segmental activity (123I and 99mTc). CONCLUSIONS: This study found no impact of the acquisition mode (single vs dual) or the type of camera (DSPECT vs DNM 530c) on 123I and 99mTc defect size and mismatch, providing a new step toward simultaneous dual-isotope acquisition for combined innervation and perfusion assessment.
Authors: P Merlet; C Benvenuti; D Moyse; F Pouillart; J L Dubois-Randé; A M Duval; D Loisance; A Castaigne; A Syrota Journal: J Nucl Med Date: 1999-06 Impact factor: 10.057
Authors: Mohammed Abdulghani; John Duell; Mark Smith; Wengen Chen; Søren M Bentzen; Ramazan Asoglu; Tomas Klein; Tamunoinemi Bob-Manuel; Anastasios Saliaris; Vincent See; Stephen Shorofsky; Vasken Dilsizian; Timm Dickfeld Journal: J Nucl Med Date: 2015-06 Impact factor: 10.057
Authors: Hein J Verberne; Wanda Acampa; Constantinos Anagnostopoulos; Jim Ballinger; Frank Bengel; Pieter De Bondt; Ronny R Buechel; Alberto Cuocolo; Berthe L F van Eck-Smit; Albert Flotats; Marcus Hacker; Cecilia Hindorf; Philip A Kaufmann; Oliver Lindner; Michael Ljungberg; Markus Lonsdale; Alain Manrique; David Minarik; Arthur J H A Scholte; Riemer H J A Slart; Elin Trägårdh; Tim C de Wit; Birger Hesse Journal: Eur J Nucl Med Mol Imaging Date: 2015-08-21 Impact factor: 9.236