Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Continuous multi-modality brain imaging reveals modified neurovascular seizure response after intervention.

Literature DB >> 28270990

Continuous multi-modality brain imaging reveals modified neurovascular seizure response after intervention.

Dene Ringuette¹, Melanie A Jeffrey², Suzie Dufour³, Peter L Carlen³, Ofer Levi⁴.

Abstract

We developed a multi-modal brain imaging system to investigate the relationship between blood flow, blood oxygenation/volume, intracellular calcium and electrographic activity during acute seizure-like events (SLEs), both before and after pharmacological intervention. Rising blood volume was highly specific to SLE-onset whereas blood flow was more correlated with all eletrographic activity. Intracellular calcium spiked between SLEs and at SLE-onset with oscillation during SLEs. Modified neurovascular and ionic SLE responses were observed after intervention and the interval between SLEs became shorter and more inconsistent. Comparison of artery and vein pulsatile flow suggest proximal interference and greater vascular leakage prior to intervention.

Entities: Chemical Disease

Keywords: (110.4234) Multispectral and hyperspectral imaging; (110.6150) Speckle imaging; (170.2520) Fluorescence microscopy

Year: 2017 PMID： 28270990 PMCID： PMC5330586 DOI： 10.1364/BOE.8.000873

Source DB: PubMed Journal: Biomed Opt Express ISSN： 2156-7085 Impact factor: 3.732

19 in total

1. Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal.

Authors: Peifang Tian; Ivan C Teng; Larry D May; Ronald Kurz; Kun Lu; Miriam Scadeng; Elizabeth M C Hillman; Alex J De Crespigny; Helen E D'Arceuil; Joseph B Mandeville; John J A Marota; Bruce R Rosen; Thomas T Liu; David A Boas; Richard B Buxton; Anders M Dale; Anna Devor
Journal: Proc Natl Acad Sci U S A Date: 2010-08-09 Impact factor: 11.205

2. Intraoperative laser speckle contrast imaging with retrospective motion correction for quantitative assessment of cerebral blood flow.

Authors: Lisa M Richards; Erica L Towle; Douglas J Fox; Andrew K Dunn
Journal: Neurophotonics Date: 2014-08-18 Impact factor: 3.593

Continuous multi-modality brain imaging reveals modified neurovascular seizure response after intervention.

1. Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal.

2. Intraoperative laser speckle contrast imaging with retrospective motion correction for quantitative assessment of cerebral blood flow.

3. Multi-modality optical neural imaging using coherence control of VCSELs.

4. Diverse voltage-sensitive dyes modulate GABAA receptor function.

5. Wide field fluorescent imaging of extracellular spatiotemporal potassium dynamics in vivo.

6. Low-dose benzodiazepine neuronal inhibition: enhanced Ca2+-mediated K+-conductance.

7. Preictal and ictal neurovascular and metabolic coupling surrounding a seizure focus.

8. Epilepsy and cognition.

9. Intrinsic optical signal imaging of neocortical seizures: the 'epileptic dip'.

10. Rapid monitoring of cerebral ischemia dynamics using laser-based optical imaging of blood oxygenation and flow.

1. Data compression and improved registration for laser speckle contrast imaging of rodent brains.

2. Decoding cortical brain states from widefield calcium imaging data using visibility graph.

3. Visualization of blood-brain barrier disruption with dual-wavelength high-resolution photoacoustic microscopy.