| Literature DB >> 6311332 |
P L Carlen, N Gurevich, P Polc.
Abstract
The water-soluble inhibitory benzodiazepine, midazolam, was applied in low nanomolar concentrations to CA1 hippocampal neurons in vitro, recorded intracellularly. The drug caused a long-lasting hyperpolarization and moderate conductance increase, which persisted with TTX-induced synaptic blockade or with intracellular injection of Cl- ions, but not in zero Ca2+ perfusate. Calcium spikes elicited in the presence of TTX were enhanced by midazolam. It was concluded that these low nanomolar concentrations, which did not enhance GABA actions, inhibited by augmenting Ca2+ mediated K+-conductance.Entities:
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Year: 1983 PMID： 6311332 DOI： 10.1016/0006-8993(83)90302-5
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252