Literature DB >> 2826820

Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors.

C Pasquinelli1, F Garreau, L Bougueleret, E Cariani, K H Grzeschik, V Thiers, O Croissant, M Hadchouel, P Tiollais, C Bréchot.   

Abstract

Hepatitis B virus (HBV) DNA integration has been shown to occur frequently in human hepatocellular carcinomas. We have investigated whether common cellular DNA domains might be rearranged, possibly by HBV integration, in human primary liver tumors. Unique cellular DNA sequences adjacent to an HBV integration site were isolated from a patient with hepatitis B surface antigen-positive hepatocellular carcinoma. These probes detected rearrangement of this cellular region of chromosomal DNA in 3 of 50 additional primary liver tumors studied. Of these three tumor samples, two contained HBV DNA, without an apparent link between the viral DNA and the rearranged allele; HBV DNA sequences were not detected in the third tumor sample. By use of a panel of somatic cell hybrids, these unique cellular DNA sequences were shown to be located on chromosome 4. Therefore, this region of chromosomal DNA might be implicated in the formation of different tumors at one step of liver cell transformation, possibly related to HBV integration.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 2826820      PMCID： PMC250581          DOI： 10.1128/JVI.62.2.629-632.1988

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  19 in total

1.  Genomic localization of hepatitis B virus in a human hepatoma cell line.

Authors:  M Zerial; J Salinas; J Filipski; G Bernardi
Journal:  Nucleic Acids Res       Date:  1986-11-11       Impact factor: 16.971

2.  A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene.

Authors:  S D Gillies; S L Morrison; V T Oi; S Tonegawa
Journal:  Cell       Date:  1983-07       Impact factor: 41.582

3.  A common philosophy and FORTRAN 77 software package for implementing and searching sequence databases.

Authors:  J M Claverie
Journal:  Nucleic Acids Res       Date:  1984-01-11       Impact factor: 16.971

4.  Hepatitis B virus integration in hepatocellular carcinoma DNA: duplication of cellular flanking sequences at the integration site.

Authors:  K Yaginuma; M Kobayashi; E Yoshida; K Koike
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

5.  Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat.

Authors:  A Dejean; P Sonigo; S Wain-Hobson; P Tiollais
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

6.  Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma.

Authors:  C Brechot; C Pourcel; A Louise; B Rain; P Tiollais
Journal:  Nature       Date:  1980-07-31       Impact factor: 49.962

7.  State of hepatitis B viral DNA in a human hepatoma cell line.

Authors:  P L Marion; F H Salazar; J J Alexander; W S Robinson
Journal:  J Virol       Date:  1980-02       Impact factor: 5.103

8.  Deletion in chromosome 11p associated with a hepatitis B integration site in hepatocellular carcinoma.

Authors:  C E Rogler; M Sherman; C Y Su; D A Shafritz; J Summers; T B Shows; A Henderson; M Kew
Journal:  Science       Date:  1985-10-18       Impact factor: 47.728

9.  Characterization of integrated hepatitis B viral DNA cloned from a human hepatoma and the hepatoma-derived cell line PLC/PRF/5.

Authors:  A Dejean; C Brechot; P Tiollais; S Wain-Hobson
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205

10.  Integration of hepatitis B virus DNA: evidence for integration in the single-stranded gap.

Authors:  R Koshy; S Koch; A F von Loringhoven; R Kahmann; K Murray; P H Hofschneider
Journal:  Cell       Date:  1983-08       Impact factor: 41.582
View more
  12 in total

1.  Regional mapping to 4q32.1 by in situ hybridization of a DNA domain rearranged in human liver cancer.

Authors:  V Blanquet; F Garreau; X Chenivesse; C Brechot; C Turleau
Journal:  Hum Genet       Date:  1988-11       Impact factor: 4.132

2.  Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma.

Authors:  K H Buetow; J C Murray; J L Israel; W T London; M Smith; M Kew; V Blanquet; C Brechot; A Redeker; S Govindarajah
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

3.  Chromosomal sites for hepatitis B virus integration in human hepatocellular carcinoma.

Authors:  T Tokino; K Matsubara
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103

4.  A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates.

Authors:  K H Buetow; R Shiang; P Yang; Y Nakamura; G M Lathrop; R White; J J Wasmuth; S Wood; L D Berdahl; N J Leysens
Journal:  Am J Hum Genet       Date:  1991-05       Impact factor: 11.025

5.  Structural analysis of a hepatitis B virus genome integrated into chromosome 17p of a human hepatocellular carcinoma.

Authors:  Y Z Zhou; B L Slagle; L A Donehower; P vanTuinen; D H Ledbetter; J S Butel
Journal:  J Virol       Date:  1988-11       Impact factor: 5.103

6.  Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.

Authors:  H Tsuda; W D Zhang; Y Shimosato; J Yokota; M Terada; T Sugimura; T Miyamura; S Hirohashi
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

Review 7.  Hepatitis B virus infection and primary hepatocellular carcinoma.

Authors:  M Feitelson
Journal:  Clin Microbiol Rev       Date:  1992-07       Impact factor: 26.132

8.  New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis.

Authors:  J Tian; Z Y Tang; S L Ye; Y K Liu; Z Y Lin; J Chen; Q Xue
Journal:  Br J Cancer       Date:  1999-11       Impact factor: 7.640

9.  Frequent genomic imbalances suggest commonly altered tumour genes in human hepatocarcinogenesis.

Authors:  F Niketeghad; H J Decker; W H Caselmann; P Lund; F Geissler; H P Dienes; P Schirmacher
Journal:  Br J Cancer       Date:  2001-09-01       Impact factor: 7.640

10.  Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade--results of an explorative CGH meta-analysis.

Authors:  P Moinzadeh; K Breuhahn; H Stützer; P Schirmacher
Journal:  Br J Cancer       Date:  2005-03-14       Impact factor: 7.640
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.