Nitin Shivappa1,2,3, Cindy K Blair4,5, Anna E Prizment6,7, David R Jacobs6, James R Hébert8,9,10. 1. Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, 29208, USA. shivappa@mailbox.sc.edu. 2. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208, USA. shivappa@mailbox.sc.edu. 3. Connecting Health Innovation, 1417 Gregg St, Columbia, SC, 29250, USA. shivappa@mailbox.sc.edu. 4. Department of Internal Medicine, University of New Mexico, Albuquerque, NM, 87131, USA. 5. University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, 87131, USA. 6. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA. 7. Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA. 8. Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, 29208, USA. 9. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208, USA. 10. Connecting Health Innovation, 1417 Gregg St, Columbia, SC, 29250, USA.
Abstract
BACKGROUND: The association between inflammatory potential of diet and renal cancer risk has not been investigated. METHODS: In this study, we explored the association between the dietary inflammatory index (DII) and risk of renal cancer in the Iowa Women's Health Study. From 1986 to 2011, 33,817 women initially recruited at 55-69 years of age were followed for incident renal cancers (n = 263). The DII was computed based on dietary intake assessed using a reproducible and valid 121-item food frequency questionnaire. Cox proportional hazards regression was used to estimate hazard ratios (HR) adjusting for age, body mass index, energy intake, smoking status, education, pack years of smoking, hypertension, and hormone replacement therapy. RESULTS: Multivariable analyses revealed positive association between higher DII scores and renal cancer risk (HR for DIIcontinuous: 1.07 per unit increase in DII (corresponding to 10% change in the DII range in the current study); 95% CI 1.00, 1.15; HR for DIItertile3vs1 = 1.52; 95% CI 1.09, 2.13). Stratified analyses produced slightly stronger associations between DII and renal cancer risk among women with BMI <30 kg/m2 (HRTertile3vs1 = 1.57; 95% CI = 1.04, 2.36) and ever smokers (HRtertile3vs1 = 2.35; 95% CI = 1.22, 4.55), although the corresponding interaction p values were not significant. CONCLUSION: Pro-inflammatory diet, as indicated by higher DII scores, was associated with increased renal cancer risk.
BACKGROUND: The association between inflammatory potential of diet and renal cancer risk has not been investigated. METHODS: In this study, we explored the association between the dietary inflammatory index (DII) and risk of renal cancer in the Iowa Women's Health Study. From 1986 to 2011, 33,817 women initially recruited at 55-69 years of age were followed for incident renal cancers (n = 263). The DII was computed based on dietary intake assessed using a reproducible and valid 121-item food frequency questionnaire. Cox proportional hazards regression was used to estimate hazard ratios (HR) adjusting for age, body mass index, energy intake, smoking status, education, pack years of smoking, hypertension, and hormone replacement therapy. RESULTS: Multivariable analyses revealed positive association between higher DII scores and renal cancer risk (HR for DIIcontinuous: 1.07 per unit increase in DII (corresponding to 10% change in the DII range in the current study); 95% CI 1.00, 1.15; HR for DIItertile3vs1 = 1.52; 95% CI 1.09, 2.13). Stratified analyses produced slightly stronger associations between DII and renal cancer risk among women with BMI <30 kg/m2 (HRTertile3vs1 = 1.57; 95% CI = 1.04, 2.36) and ever smokers (HRtertile3vs1 = 2.35; 95% CI = 1.22, 4.55), although the corresponding interaction p values were not significant. CONCLUSION: Pro-inflammatory diet, as indicated by higher DII scores, was associated with increased renal cancer risk.
Entities:
Keywords:
Cohort; Diet; Dietary inflammatory index (DII); Inflammation; Renal cancer risk
Authors: Nitin Shivappa; Anna E Prizment; Cindy K Blair; David R Jacobs; Susan E Steck; James R Hébert Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-08-25 Impact factor: 4.254
Authors: Fred K Tabung; Susan E Steck; Jiajia Zhang; Yunsheng Ma; Angela D Liese; Ilir Agalliu; Melanie Hingle; Lifang Hou; Thomas G Hurley; Li Jiao; Lisa W Martin; Amy E Millen; Hannah L Park; Milagros C Rosal; James M Shikany; Nitin Shivappa; Judith K Ockene; James R Hebert Journal: Ann Epidemiol Date: 2015-03-19 Impact factor: 3.797
Authors: Ramon Estruch; Miguel Angel Martínez-González; Dolores Corella; Jordi Salas-Salvadó; Valentina Ruiz-Gutiérrez; María Isabel Covas; Miguel Fiol; Enrique Gómez-Gracia; Mari Carmen López-Sabater; Ernest Vinyoles; Fernando Arós; Manuel Conde; Carlos Lahoz; José Lapetra; Guillermo Sáez; Emilio Ros Journal: Ann Intern Med Date: 2006-07-04 Impact factor: 25.391
Authors: Nitin Shivappa; James R Hébert; Ernst R Rietzschel; Marc L De Buyzere; Michel Langlois; Evi Debruyne; Ascensión Marcos; Inge Huybrechts Journal: Br J Nutr Date: 2015-02-02 Impact factor: 3.718
Authors: Michael D Wirth; James Burch; Nitin Shivappa; John M Violanti; Cecil M Burchfiel; Desta Fekedulegn; Michael E Andrew; Tara A Hartley; Diane B Miller; Anna Mnatsakanova; Luenda E Charles; Susan E Steck; Thomas G Hurley; John E Vena; James R Hébert Journal: J Occup Environ Med Date: 2014-09 Impact factor: 2.162
Authors: Nitin Shivappa; James R Hébert; Valentina Rosato; Marta Rossi; Massimo Libra; Maurizio Montella; Diego Serraino; Carlo La Vecchia Journal: Urology Date: 2016-09-29 Impact factor: 2.649
Authors: Nitin Shivappa; Antonella Zucchetto; Maurizio Montella; Diego Serraino; Susan E Steck; Carlo La Vecchia; James R Hébert Journal: Br J Nutr Date: 2015-06-08 Impact factor: 3.718
Authors: Nitin Shivappa; James R Hébert; Valentina Rosato; Marta Rossi; Maurizio Montella; Diego Serraino; Carlo La Vecchia Journal: Nutr Cancer Date: 2017-07-18 Impact factor: 2.900
Authors: Avelina C Padin; James R Hébert; Alex Woody; Stephanie J Wilson; Nitin Shivappa; Martha A Belury; William B Malarkey; John F Sheridan; Janice K Kiecolt-Glaser Journal: Brain Behav Immun Date: 2019-07-26 Impact factor: 7.217
Authors: Melissa Lopez-Pentecost; Tracy E Crane; David O Garcia; Lindsay N Kohler; Betsy C Wertheim; James R Hebert; Susan E Steck; Nitin Shivappa; Margarita Santiago-Torres; Marian L Neuhouser; Irene E Hatsu; Linda Snetselaar; Mridul Datta; Candyce H Kroenke; Gloria E Sarto; Cynthia A Thomson Journal: Z Gesundh Wiss Date: 2020-07-14
Authors: M Kyla Shea; Andres V Ardisson Korat; Paul F Jacques; Paola Sebastiani; Rebecca Cohen; Amy E LaVertu; Sarah L Booth Journal: Adv Nutr Date: 2022-10-02 Impact factor: 11.567
Authors: Michael D Wirth; Maria Sevoyan; Lorne Hofseth; Nitin Shivappa; Thomas G Hurley; James R Hébert Journal: Brain Behav Immun Date: 2017-12-05 Impact factor: 7.217
Authors: Catherine M Phillips; Ling-Wei Chen; Barbara Heude; Jonathan Y Bernard; Nicholas C Harvey; Liesbeth Duijts; Sara M Mensink-Bout; Kinga Polanska; Giulia Mancano; Matthew Suderman; Nitin Shivappa; James R Hébert Journal: Nutrients Date: 2019-08-12 Impact factor: 5.717