Literature DB >> 2824272

Monoclonal antibodies against human scirrhous carcinoma of the stomach.

T Yokota1, T Takahashi, T Yamaguchi, K Kitamura, T Masuko, Y Hashimoto.   

Abstract

We established three monoclonal antibodies (MoAbs) S43, S74 and S202 which reacted strongly with scirrhous carcinomas of the stomach. MoAb S43 reacted with culture supernatants of the scirrhous gastric cancer cell line MK-01, and thus may be useful for in vivo detection of markers for this tumor. MoAb S74 reacted with the majority of gastric cancer tissues, but showed no reaction with normal tissues. It may be useful as a drug carrier in targeting chemotherapy against scirrhous gastric cancer, because of its tumor specificity. MoAb S202 reacted strongly with 100% of scirrhous gastric cancer samples and with the culture supernatants of colonic and pancreatic cancers.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2824272     DOI： 10.1007/BF02776715

Source DB:  PubMed          Journal:  Gastroenterol Jpn        ISSN： 0435-1339


  5 in total

1.  Carbohydrate antigen defined by a monoclonal antibody raised against a gastric cancer xenograft.

Authors:  M Watanabe; S Hirohashi; Y Shimosato; Y Ino; T Yamada; S Teshima; T Sekine; O Abe
Journal:  Jpn J Cancer Res       Date:  1985-01

2.  Release of monoclonal antibody-defined antigens by human colorectal carcinoma and melanoma cells.

Authors:  Z Steplewski; T H Chang; M Herlyn; H Koprowski
Journal:  Cancer Res       Date:  1981-07       Impact factor: 12.701

3.  A monoclonal antibody reactive with gastric carcinoma.

Authors:  T Sekine; S Hirohashi; H Kitaoka; T Hirota; T Sugimura
Journal:  Gan       Date:  1984-02

4.  Monoclonal antibody detection of a circulating tumor-associated antigen. I. Presence of antigen in sera of patients with colorectal, gastric, and pancreatic carcinoma.

Authors:  M Herlyn; H F Sears; Z Steplewski; H Koprowski
Journal:  J Clin Immunol       Date:  1982-04       Impact factor: 8.317

5.  A monoclonal antibody, CSTO-1, against a stomach adenocarcinoma-associated antigen.

Authors:  H Togashi; P I Terasaki; D Chia; G Kukes; H Mugishima; K Kasai; N Suyama; K Fukushima; M Hirota
Journal:  Cancer Res       Date:  1984-09       Impact factor: 12.701
  5 in total
  5 in total

1.  Localization of antigen defined by anti-scirrhous gastric carcinoma monoclonal antibody S202 in fixed human cancer tissues.

Authors:  T Yokota; T Takahashi; T Yamaguchi; K Sawai; M Shimotsuma; M Doi; T Masuko; Y Hashimoto
Journal:  Gastroenterol Jpn       Date:  1988-12

2.  Characterization of a newly established cell line (JR-St) derived from human gastric signet ring cell cancer, producing tumor markers.

Authors:  A Terano; R Nakada; H Mutoh; H Hiraishi; S Ota; S Shiina; T Shimada; Y Itoh; K Kimura; J Shiga
Journal:  Gastroenterol Jpn       Date:  1991-02

3.  A rapid immunostaining method for scirrhous gastric cancer during surgery using a monoclonal antibody.

Authors:  T Yokota; T Takahashi; T Yamaguchi; K Sawai; E Otsuji; K Kitamura; H Suzuyama; T Yamane; Y Fujita
Journal:  Jpn J Surg       Date:  1988-03

4.  Histological diagnosis of scirrhous carcinoma of the stomach using monoclonal antibody S202.

Authors:  T Yokota; T Takahashi; T Yamaguchi; K Sawai; E Otsuji; K Kitamura; T Yamane; Y Fujita
Journal:  Gastroenterol Jpn       Date:  1988-02

5.  Localization of radiolabeled monoclonal antibody S74 in human scirrhous type gastric cancer xenografts in nude mice.

Authors:  T Yokota; T Takahashi; T Yamaguchi; E Otsuji; K Sawai; S Kitai; K Kitamura; A Noguchi; T Ahn
Journal:  Gastroenterol Jpn       Date:  1987-12
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.