Ricardo Morais1,2, Benjamin Mine3, Pierre Julien Bruyère3,4, Gilles Naeije5, Boris Lubicz3. 1. Cliniques Universitaires de Bruxelles, Erasme University Hospital, Imagerie médicale - Clinique de Neuroradiologie, Route de Lennik 808 - B, Bruxelles, Belgium. ricardofelixmorais@gmail.com. 2. Medical Imaging Department, Coimbra University and Hospital Centre, Coimbra, Portugal. ricardofelixmorais@gmail.com. 3. Cliniques Universitaires de Bruxelles, Erasme University Hospital, Imagerie médicale - Clinique de Neuroradiologie, Route de Lennik 808 - B, Bruxelles, Belgium. 4. Department of Radiology, Centre Hospitalier Régional Citadelle, Radiology, Liège, Belgium. 5. Department of Neurology, Erasme University Hospital, Brussels, Belgium.
Abstract
INTRODUCTION: The p64 flow diverter (FD) device is a fully resheathable and detachable stent dedicated for endovascular treatment (EVT) of intracranial aneurysms (IAs). We report our mid-term experience with this device. METHODS: Between January 2015 and February 2016, we retrospectively identified, in our prospectively maintained database, all patients treated with p64 FDs in two institutions. Independent clinical follow-up was performed by a vascular neurologist. Imaging follow-up included a digitalized subtraction angiography (DSA) at 3, 6, and 12 months and a magnetic resonance angiography (MRA) at 12 months. RESULTS: Thirty-nine patients (22 women/17 men; median age 54 years) with 48 IAs (median aneurysm size 6.2 mm; mean neck size 3.4 mm) were identified. All IAs were saccular and unruptured. Failure of safe stent delivery occurred in 15% of cases (7/48 IAs) which were excluded. Transient neurological morbidity occurred in 2/35 patients (5.7%) including one delayed thromboembolic complication. No permanent morbidity or mortality was encountered. Complete aneurysmal occlusion at 3, 6, and 12 months was 20/30 (66.6%), 18/27 (66.6%), and 24/28 (85.7%), respectively. Intra-stent stenosis was observed in 9/29 patients (31%) and classified as moderate in 4/29 (13.7%) and mild in 5/29 patients (17.2%). These stenoses gradually improved over time, with only mild stenoses being identified at 6 months and at 12 months. CONCLUSION: In our small case series, the p64 FD stent appears safe and effective for EVT of IAs. A high occlusion rate and a low morbidity rate were observed.
INTRODUCTION: The p64 flow diverter (FD) device is a fully resheathable and detachable stent dedicated for endovascular treatment (EVT) of intracranial aneurysms (IAs). We report our mid-term experience with this device. METHODS: Between January 2015 and February 2016, we retrospectively identified, in our prospectively maintained database, all patients treated with p64 FDs in two institutions. Independent clinical follow-up was performed by a vascular neurologist. Imaging follow-up included a digitalized subtraction angiography (DSA) at 3, 6, and 12 months and a magnetic resonance angiography (MRA) at 12 months. RESULTS: Thirty-nine patients (22 women/17 men; median age 54 years) with 48 IAs (median aneurysm size 6.2 mm; mean neck size 3.4 mm) were identified. All IAs were saccular and unruptured. Failure of safe stent delivery occurred in 15% of cases (7/48 IAs) which were excluded. Transient neurological morbidity occurred in 2/35 patients (5.7%) including one delayed thromboembolic complication. No permanent morbidity or mortality was encountered. Complete aneurysmal occlusion at 3, 6, and 12 months was 20/30 (66.6%), 18/27 (66.6%), and 24/28 (85.7%), respectively. Intra-stent stenosis was observed in 9/29 patients (31%) and classified as moderate in 4/29 (13.7%) and mild in 5/29 patients (17.2%). These stenoses gradually improved over time, with only mild stenoses being identified at 6 months and at 12 months. CONCLUSION: In our small case series, the p64FD stent appears safe and effective for EVT of IAs. A high occlusion rate and a low morbidity rate were observed.
Authors: Francesco Briganti; Giuseppe Leone; Mariano Marseglia; Giuseppe Mariniello; Ferdinando Caranci; Arturo Brunetti; Francesco Maiuri Journal: Neuroradiol J Date: 2015-08-27
Authors: A K Wakhloo; P Lylyk; J de Vries; C Taschner; J Lundquist; A Biondi; M Hartmann; I Szikora; L Pierot; N Sakai; H Imamura; N Sourour; I Rennie; M Skalej; O Beuing; A Bonafé; F Mery; F Turjman; P Brouwer; E Boccardi; L Valvassori; S Derakhshani; M W Litzenberg; M J Gounis Journal: AJNR Am J Neuroradiol Date: 2014-08-14 Impact factor: 3.825
Authors: A Rouchaud; O Leclerc; Y Benayoun; S Saleme; Y Camilleri; F D'Argento; M-P Boncoeur; P-Y Robert; C Mounayer Journal: AJNR Am J Neuroradiol Date: 2014-10-22 Impact factor: 3.825
Authors: Zsolt Kulcsár; Ulrike Ernemann; Stephan G Wetzel; Alexander Bock; Sophia Goericke; Vasilis Panagiotopoulos; Michael Forsting; Daniel A Ruefenacht; Isabel Wanke Journal: Stroke Date: 2010-07-08 Impact factor: 7.914
Authors: Geoffrey P Colby; Li-Mei Lin; Justin M Caplan; Bowen Jiang; Barbara Michniewicz; Judy Huang; Rafael J Tamargo; Alexander L Coon Journal: J Neurointerv Surg Date: 2015-05-18 Impact factor: 5.836
Authors: F Cagnazzo; P Perrini; C Dargazanli; P-H Lefevre; G Gascou; R Morganti; D di Carlo; I Derraz; C Riquelme; A Bonafe; V Costalat Journal: AJNR Am J Neuroradiol Date: 2019-03-14 Impact factor: 3.825
Authors: Marta Aguilar Pérez; Elina Henkes; Victoria Hellstern; Carmen Serna Candel; Christina Wendl; Hansjörg Bäzner; Oliver Ganslandt; Hans Henkes Journal: Oper Neurosurg (Hagerstown) Date: 2021-03-15 Impact factor: 2.703
Authors: Alain Bonafe; Marta Aguilar Perez; Hans Henkes; Pedro Lylyk; Carlos Bleise; Gregory Gascou; Stanimir Sirakov; Alexander Sirakov; Luc Stockx; Francis Turjman; Andrey Petrov; Christian Roth; Ana-Paula Narata; Xavier Barreau; Christian Loehr; Ansgar Berlis; Laurent Pierot; Marcin Miś; Tony Goddard; Andy Clifton; Joachim Klisch; Cezary Wałęsa; Massimo Dall'Olio; Laurent Spelle; Frédéric Clarencon; Sergey Yakovlev; Peter Keston; Nunzio Paolo Nuzzi; Stefanita Dima; Christina Wendl; Tine Willems; Peter Schramm Journal: J Neurointerv Surg Date: 2021-11-15 Impact factor: 8.572
Authors: Jessica K Campos; Barry Cheaney Ii; Brian V Lien; David A Zarrin; Chau D Vo; Geoffrey P Colby; Li-Mei Lin; Alexander L Coon Journal: Stroke Vasc Neurol Date: 2020-03-25