Literature DB >> 28233490

Identification and Characterization of Enzymes Catalyzing Pyrazolopyrimidine Formation in the Biosynthesis of Formycin A.

Yeonjin Ko1, Shao-An Wang1, Yasushi Ogasawara2, Mark W Ruszczycky2, Hung-Wen Liu1,2.   

Abstract

Genome scanning of Streptomyces kaniharaensis, the producer of formycin A, reveals two sets of purA, purB, purC, and purH genes. The Pur enzymes catalyze pyrimidine assembly of purine nucleobases. To test whether enzymes encoded by the second set of pur genes catalyze analogous transformations in formycin biosynthesis, formycin B 5'-phosphate was synthesized and shown to be converted by ForA and ForB to formycin A 5'-phosphate. These results support that For enzymes are responsible for formycin formation.

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Year:  2017        PMID： 28233490      PMCID： PMC5467530          DOI： 10.1021/acs.orglett.7b00355

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  25 in total

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Authors:  Mary C Long; William B Parker
Journal:  Biochem Pharmacol       Date:  2006-03-10       Impact factor: 5.858

2.  Formycins A and B and some analogues: selective inhibitors of bacterial (Escherichia coli) purine nucleoside phosphorylase.

Authors:  A Bzowska; E Kulikowska; D Shugar
Journal:  Biochim Biophys Acta       Date:  1992-04-17

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Journal:  Biochemistry       Date:  1972-07-04       Impact factor: 3.162

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Authors:  T Kunimoto; T Sawa; T Wakashiro; M Hori; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1971-04       Impact factor: 2.649

5.  Antiviral effect of formycin and formycin B.

Authors:  T Takeuchi; J Iwanaga; T Aoyagi; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1966-11       Impact factor: 2.649

6.  Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1.

Authors:  Michael J Dapp; Laurent Bonnac; Steven E Patterson; Louis M Mansky
Journal:  J Virol       Date:  2013-10-23       Impact factor: 5.103

7.  Predicted class-I aminoacyl tRNA synthetase-like proteins in non-ribosomal peptide synthesis.

Authors:  L Aravind; Robson F de Souza; Lakshminarayan M Iyer
Journal:  Biol Direct       Date:  2010-08-02       Impact factor: 4.540

8.  Mechanism of 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase, a key enzyme in the methanopterin biosynthetic pathway.

Authors:  Razvan V Dumitru; Stephen W Ragsdale
Journal:  J Biol Chem       Date:  2004-07-15       Impact factor: 5.157

9.  Lysine catabolism in Streptomyces spp. is primarily through cadaverine: beta-lactam producers also make alpha-aminoadipate.

Authors:  K Madduri; C Stuttard; L C Vining
Journal:  J Bacteriol       Date:  1989-01       Impact factor: 3.490

10.  Biosynthesis of formycin. Incorporation and distribution of 13C-, 14C-, and 15N-labeled compounds into formycin.

Authors:  K Ochi; S Yashima; Y Eguchi; K Matsushita
Journal:  J Biol Chem       Date:  1979-09-25       Impact factor: 5.157
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  8 in total

1.  Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay between Biological Pyrazolopyrimidine Formation and de Novo Purine Biosynthesis.

Authors:  Shao-An Wang; Yeonjin Ko; Jia Zeng; Yujie Geng; Daan Ren; Yasushi Ogasawara; Seema Irani; Yan Zhang; Hung-Wen Liu
Journal:  J Am Chem Soc       Date:  2019-04-08       Impact factor: 15.419

2.  Identification of the C-Glycoside Synthases during Biosynthesis of the Pyrazole-C-Nucleosides Formycin and Pyrazofurin.

Authors:  Daan Ren; Shao-An Wang; Yeonjin Ko; Yujie Geng; Yasushi Ogasawara; Hung-Wen Liu
Journal:  Angew Chem Int Ed Engl       Date:  2019-10-07       Impact factor: 15.336

Review 3.  Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments.

Authors:  Meng Zhang; Liyuan Kong; Rong Gong; Marianna Iorio; Stefano Donadio; Zixin Deng; Margherita Sosio; Wenqing Chen
Journal:  Microb Cell Fact       Date:  2022-01-04       Impact factor: 5.328

4.  Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds.

Authors:  Meng Zhang; Peichao Zhang; Gudan Xu; Wenting Zhou; Yaojie Gao; Rong Gong; You-Sheng Cai; Hengjiang Cong; Zixin Deng; Neil P J Price; Xiangzhao Mao; Wenqing Chen
Journal:  Appl Environ Microbiol       Date:  2020-01-07       Impact factor: 4.792

Review 5.  Recent advances in the biosynthesis of nucleoside antibiotics.

Authors:  Taro Shiraishi; Tomohisa Kuzuyama
Journal:  J Antibiot (Tokyo)       Date:  2019-09-25       Impact factor: 2.649

6.  PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis.

Authors:  Sisi Gao; Huanting Liu; Valérie de Crécy-Lagard; Wen Zhu; Nigel G J Richards; James H Naismith
Journal:  Chem Commun (Camb)       Date:  2019-11-28       Impact factor: 6.222

Review 7.  Recent advances in synthetic approaches for medicinal chemistry of C-nucleosides.

Authors:  Kartik Temburnikar; Katherine L Seley-Radtke
Journal:  Beilstein J Org Chem       Date:  2018-04-05       Impact factor: 2.883

8.  Whole-Genome Sequence of Streptomyces kaniharaensis Shomura and Niida SF-557.

Authors:  Wen Zhu; Xuan Liu; Margaret Hughes; Valérie de Crécy-Lagard; Nigel G J Richards
Journal:  Microbiol Resour Announc       Date:  2020-04-02
  8 in total

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