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Literature DB >> 28232895

Paradoxes and wonders of intrinsic disorder: Complexity of simplicity.

Abstract

At first glance it may seem that intrinsically disordered proteins (IDPs) and IDP regions (IDPRs) are simpler than ordered proteins and domains on multiple levels. However, such multilevel simplicity equips these proteins with the ability to have very complex behavior.

Entities: Disease

Keywords: amino acid alphabet; complexity; functional complexity; intrinsically disordered proteins; structural content; structural heterogeneity

Year: 2016 PMID： 28232895 PMCID： PMC5314917 DOI： 10.1080/21690707.2015.1135015

Source DB: PubMed Journal: Intrinsically Disord Proteins ISSN： 2169-0707

56 in total

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Review 6. Unusual biophysics of intrinsically disordered proteins.

Authors: Vladimir N Uversky
Journal: Biochim Biophys Acta Date: 2012-12-23

7. Dynamic cross-talk among remote binding sites: the molecular basis for unusual synergistic allostery.

Authors: Wanting Jiao; Richard D Hutton; Penelope J Cross; Geoffrey B Jameson; Emily J Parker
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Review 8. NMR insights into protein allostery.

Authors: Gregory Manley; J Patrick Loria
Journal: Arch Biochem Biophys Date: 2011-12-16 Impact factor: 4.013

9. Alternative splicing in concert with protein intrinsic disorder enables increased functional diversity in multicellular organisms.

Authors: Pedro R Romero; Saima Zaidi; Ya Yin Fang; Vladimir N Uversky; Predrag Radivojac; Christopher J Oldfield; Marc S Cortese; Megan Sickmeier; Tanguy LeGall; Zoran Obradovic; A Keith Dunker
Journal: Proc Natl Acad Sci U S A Date: 2006-05-22 Impact factor: 11.205

Review 10. Intrinsically disordered proteins in human diseases: introducing the D2 concept.

Authors: Vladimir N Uversky; Christopher J Oldfield; A Keith Dunker
Journal: Annu Rev Biophys Date: 2008 Impact factor: 12.981

18 in total

Review 1. Intrinsically disordered proteins in crowded milieu: when chaos prevails within the cellular gumbo.

Authors: Alexander V Fonin; April L Darling; Irina M Kuznetsova; Konstantin K Turoverov; Vladimir N Uversky
Journal: Cell Mol Life Sci Date: 2018-07-31 Impact factor: 9.261

Review 2. Proximity Dependent Biotinylation: Key Enzymes and Adaptation to Proteomics Approaches.

Authors: Payman Samavarchi-Tehrani; Reuben Samson; Anne-Claude Gingras
Journal: Mol Cell Proteomics Date: 2020-03-03 Impact factor: 5.911

3. Paradoxes and wonders of intrinsic disorder: Stability of instability.

Authors: Vladimir N Uversky
Journal: Intrinsically Disord Proteins Date: 2017-10-16

Review 4. Protein Aggregation Landscape in Neurodegenerative Diseases: Clinical Relevance and Future Applications.

Authors: Niccolò Candelise; Silvia Scaricamazza; Illari Salvatori; Alberto Ferri; Cristiana Valle; Valeria Manganelli; Tina Garofalo; Maurizio Sorice; Roberta Misasi
Journal: Int J Mol Sci Date: 2021-06-02 Impact factor: 5.923

Review 5. The protein disorder cycle.

Authors: Vladimir N Uversky
Journal: Biophys Rev Date: 2021-11-03

Review 6. Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role?

Authors: Caitlin Pley; José Lourenço; Anna L McNaughton; Philippa C Matthews
Journal: J Virol Date: 2022-04-12 Impact factor: 6.549

7. Osmolyte Induced Tumorigenesis and Metastasis: Interactions With Intrinsically Disordered Proteins.

Authors: Franklin D Rumjanek
Journal: Front Oncol Date: 2018-08-28 Impact factor: 6.244

8. Intrinsically Disordered Proteins in Chronic Diseases.

Authors: Prakash Kulkarni; Vladimir N Uversky
Journal: Biomolecules Date: 2019-04-11

9. Structural Basis of the Subcellular Topology Landscape of Escherichia coli.

Authors: Maria S Loos; Reshmi Ramakrishnan; Wim Vranken; Alexandra Tsirigotaki; Evrydiki-Pandora Tsare; Valentina Zorzini; Jozefien De Geyter; Biao Yuan; Ioannis Tsamardinos; Maria Klappa; Joost Schymkowitz; Frederic Rousseau; Spyridoula Karamanou; Anastassios Economou
Journal: Front Microbiol Date: 2019-07-24 Impact factor: 5.640

10. Proteins of generalist and specialist pathogens differ in their amino acid composition.

Authors: Luz P Blanco; Bryan L Payne; Felix Feyertag; David Alvarez-Ponce
Journal: Life Sci Alliance Date: 2018-07-17