| Literature DB >> 28228273 |
Mary J Mattapallil1, Rachel R Caspi2.
Abstract
Genetic variations in complement factor H (CFH) confer greater risk for age-related macular degeneration (AMD). In this issue of Immunity, Calippe et al. (2017) uncover a non-canonical role for CFH in the inhibition of mononuclear phagocyte elimination from sub-retinal lesions, providing insight into the pathophysiology of AMD associated with CFH variants. Published by Elsevier Inc.Entities:
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Year: 2017 PMID: 28228273 PMCID: PMC6123247 DOI: 10.1016/j.immuni.2017.02.008
Source DB: PubMed Journal: Immunity ISSN: 1074-7613 Impact factor: 31.745