| Literature DB >> 11745332 |
A Pfeiffer1, A Böttcher, E Orsó, M Kapinsky, P Nagy, A Bodnár, I Spreitzer, G Liebisch, W Drobnik, K Gempel, M Horn, S Holmer, T Hartung, G Multhoff, G Schütz, H Schindler, A J Ulmer, H Heine, F Stelter, C Schütt, G Rothe, J Szöllôsi, S Damjanovich, G Schmitz.
Abstract
The glycosylphosphatidylinositol-anchored receptor CD14 plays a major role in the inflammatory response of monocytes to lipopolysaccharide. Here, we describe that ceramide, a constituent of atherogenic lipoproteins, binds to CD14 and induces clustering of CD14 to co-receptors in rafts. In resting cells, CD14 was associated with CD55, the Fcgamma-receptors CD32 and CD64 and the pentaspan CD47. Ceramide further recruited the complement receptor 3 (CD11b/CD18) and CD36 into proximity of CD14. Lipopolysaccharide, in addition, induced co-clustering with Toll-like receptor 4, Fcgamma-RIIIa (CD16a) and the tetraspanin CD81 while CD47 was dissociated. The different receptor complexes may be linked to ligand-specific cellular responses initiated by CD14.Entities:
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Year: 2001 PMID： 11745332 DOI： 10.1002/1521-4141(200111)31:11<3153::aid-immu3153>3.0.co;2-0
Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532