Literature DB >> 23702979

Immunology of age-related macular degeneration.

Jayakrishna Ambati1, John P Atkinson, Bradley D Gelfand.   

Abstract

Age-related macular degeneration (AMD) is a leading cause of blindness in aged individuals. Recent advances have highlighted the essential role of immune processes in the development, progression and treatment of AMD. In this Review we discuss recent discoveries related to the immunological aspects of AMD pathogenesis. We outline the diverse immune cell types, inflammatory activators and pathways that are involved. Finally, we discuss the future of inflammation-directed therapeutics to treat AMD in the growing aged population.

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Year:  2013        PMID： 23702979      PMCID： PMC3941009          DOI： 10.1038/nri3459

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  159 in total

1.  Products of lipid peroxidation induce missorting of the principal lysosomal protease in retinal pigment epithelium.

Authors:  George Hoppe; June O'Neil; Henry F Hoff; Jonathan Sears
Journal:  Biochim Biophys Acta       Date:  2004-05-24

2.  CCR2/CCL2-mediated inflammation protects photoreceptor cells from amyloid-β-induced apoptosis.

Authors:  Julien Bruban; Agathe Maoui; Naïma Chalour; Na An; Laurent Jonet; Charles Feumi; Jacques Tréton; Florian Sennlaub; Francine Behar-Cohen; Frédéric Mascarelli; Virginie Dinet
Journal:  Neurobiol Dis       Date:  2011-01-08       Impact factor: 5.996

3.  Prevalence of age-related macular degeneration in the United States.

Authors:  David S Friedman; Benita J O'Colmain; Beatriz Muñoz; Sandra C Tomany; Cathy McCarty; Paulus T V M de Jong; Barbara Nemesure; Paul Mitchell; John Kempen
Journal:  Arch Ophthalmol       Date:  2004-04

4.  The relative contributions of each subset of ocular infiltrated cells in experimental choroidal neovascularisation.

Authors:  C Tsutsumi-Miyahara; K-H Sonoda; K Egashira; M Ishibashi; H Qiao; T Oshima; T Murata; M Miyazaki; I F Charo; S Hamano; T Ishibashi
Journal:  Br J Ophthalmol       Date:  2004-09       Impact factor: 4.638

5.  An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice.

Authors:  Jayakrishna Ambati; Akshay Anand; Stefan Fernandez; Eiji Sakurai; Bert C Lynn; William A Kuziel; Barrett J Rollins; Balamurali K Ambati
Journal:  Nat Med       Date:  2003-10-19       Impact factor: 53.440

6.  Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization.

Authors:  Diego G Espinosa-Heidmann; Ivan J Suner; Eleut P Hernandez; Dagoberto Monroy; Karl G Csaky; Scott W Cousins
Journal:  Invest Ophthalmol Vis Sci       Date:  2003-08       Impact factor: 4.799

7.  Macrophage depletion inhibits experimental choroidal neovascularization.

Authors:  Eiji Sakurai; Akshay Anand; Balamurali K Ambati; Nico van Rooijen; Jayakrishna Ambati
Journal:  Invest Ophthalmol Vis Sci       Date:  2003-08       Impact factor: 4.799

8.  The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration.

Authors:  Jingsheng Tuo; Brena C Smith; Christine M Bojanowski; Annal D Meleth; Igal Gery; Karl G Csaky; Emily Y Chew; Chi-Chao Chan
Journal:  FASEB J       Date:  2004-06-18       Impact factor: 5.191

Review 9.  Proteomic approaches to understanding age-related macular degeneration.

Authors:  Joe G Hollyfield; Robert G Salomon; John W Crabb
Journal:  Adv Exp Med Biol       Date:  2003       Impact factor: 2.622

10.  Innate immunity in the retina: Toll-like receptor (TLR) signaling in human retinal pigment epithelial cells.

Authors:  Matam Vijay Kumar; Chandrasekharam N Nagineni; Marian S Chin; John J Hooks; Barbara Detrick
Journal:  J Neuroimmunol       Date:  2004-08       Impact factor: 3.478
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  249 in total

Review 1.  The stereotypical molecular cascade in neovascular age-related macular degeneration: the role of dynamic reciprocity.

Authors:  D Kent
Journal:  Eye (Lond)       Date:  2015-07-31       Impact factor: 3.775

2.  Spectrum and management of complement immunodeficiencies (excluding hereditary angioedema) across Europe.

Authors:  A J Turley; B Gathmann; C Bangs; M Bradbury; S Seneviratne; L I Gonzalez-Granado; S Hackett; N Kutukculer; H Alachkar; S Hambleton; H Ritterbusch; P Kralickova; L Marodi; M G Seidel; G Dueckers; J Roesler; A Huissoon; H Baxendale; J Litzman; P D Arkwright
Journal:  J Clin Immunol       Date:  2015-02-08       Impact factor: 8.317

Review 3.  Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging.

Authors:  Catherine Bowes Rickman; Sina Farsiu; Cynthia A Toth; Mikael Klingeborn
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-12-13       Impact factor: 4.799

4.  A role for IL-17 in age-related macular degeneration.

Authors:  Jae Il Shin; Jagadeesh Bayry
Journal:  Nat Rev Immunol       Date:  2013-09       Impact factor: 53.106

5.  The safety, pharmacokinetics, and efficacy of intraocular celecoxib.

Authors:  Stephen J Kim; Hassanain Toma; Rohan Shah; Uday B Kompella; Sunil K Vooturi; Jinsong Sheng
Journal:  Invest Ophthalmol Vis Sci       Date:  2014-03-10       Impact factor: 4.799

6.  Vascular associations and dynamic process motility in perivascular myeloid cells of the mouse choroid: implications for function and senescent change.

Authors:  Anil Kumar; Lian Zhao; Robert N Fariss; Paul G McMenamin; Wai T Wong
Journal:  Invest Ophthalmol Vis Sci       Date:  2014-03-25       Impact factor: 4.799

7.  Choroidal γδ T cells in protection against retinal pigment epithelium and retinal injury.

Authors:  Zhenyang Zhao; Yuejin Liang; Yin Liu; Pei Xu; Miles J Flamme-Wiese; Deming Sun; Jiaren Sun; Robert F Mullins; Yan Chen; Jiyang Cai
Journal:  FASEB J       Date:  2017-07-20       Impact factor: 5.191

Review 8.  ω-3 and ω-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases.

Authors:  Yan Gong; Zhongjie Fu; Raffael Liegl; Jing Chen; Ann Hellström; Lois Eh Smith
Journal:  Am J Clin Nutr       Date:  2017-05-17       Impact factor: 7.045

9.  Cholesterol crystals induce inflammatory cytokines expression in a human retinal pigment epithelium cell line by activating the NF-κB pathway.

Authors:  Yijun Hu; Haijiang Lin; Bernard Dib; Alp Atik; Peggy Bouzika; Christopher Lin; Yueran Yan; Shibo Tang; Joan W Miller; Demetrios G Vavvas
Journal:  Discov Med       Date:  2014 Jul-Aug       Impact factor: 2.970

10.  Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid.

Authors:  Sudha Ananth; Jaya P Gnana-Prakasam; Yangzom D Bhutia; Rajalakshmi Veeranan-Karmegam; Pamela M Martin; Sylvia B Smith; Vadivel Ganapathy
Journal:  Biochim Biophys Acta       Date:  2014-01-23
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