Literature DB >> 28223690

Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32.

Xiangcheng Zhu1, Yanwen Duan1, Zhaomeng Cui2, Zhen Wang2, Zengxia Li2, Yun Zhang3, Jianhua Ju3, Hongbo Huang3.   

Abstract

Two new rearranged linear angucycline glycosides, designated grincamycins G and H (1 and 2), together with three known congers P-1894B (vineomycin A1, 3), saquayamycin B (4) and vineomycin B2 (5), were obtained from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. The structures of 1 and 2 were elucidated by MS, 1D and 2D NMR techniques. Compounds 2-5 showed significant inhibitory effect on Jurkat T-cell proliferation with IC50 values of 3.0, 0.011, 0.037 and 0.3 μM, respectively.

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Year:  2017        PMID： 28223690     DOI： 10.1038/ja.2017.17

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  12 in total

Review 1.  Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis.

Authors:  Madan K Kharel; Pallab Pahari; Micah D Shepherd; Nidhi Tibrewal; S Eric Nybo; Khaled A Shaaban; Jürgen Rohr
Journal:  Nat Prod Rep       Date:  2011-12-21       Impact factor: 13.423

2.  Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32.

Authors:  Hongbo Huang; Tingting Yang; Xiangmei Ren; Jing Liu; Yongxiang Song; Aijun Sun; Junying Ma; Bo Wang; Yun Zhang; Caiguo Huang; Changsheng Zhang; Jianhua Ju
Journal:  J Nat Prod       Date:  2012-02-03       Impact factor: 4.050

Review 3.  Angucycline group antibiotics.

Authors:  J Rohr; R Thiericke
Journal:  Nat Prod Rep       Date:  1992-04       Impact factor: 13.423

4.  Quanolirones I and II, two new human cytomegalovirus protease inhibitors produced by Streptomyces sp. WC76535.

Authors:  J Qian-Cutrone; J M Kolb; K McBrien; S Huang; D Gustavson; S E Lowe; S P Manly
Journal:  J Nat Prod       Date:  1998-11       Impact factor: 4.050

5.  Identification of inhibitors of inducible nitric oxide synthase from microbial extracts.

Authors:  K A Alvi; D D Baker; V Stienecker; M Hosken; B G Nair
Journal:  J Antibiot (Tokyo)       Date:  2000-05       Impact factor: 2.649

6.  Retymicin, galtamycin B, saquayamycin Z and ribofuranosyllumichrome, novel secondary metabolites from Micromonospora sp. Tü 6368. II. Structure elucidation.

Authors:  Karsten Ströch; Axel Zeeck; Noémi Antal; Hans-Peter Fiedler
Journal:  J Antibiot (Tokyo)       Date:  2005-02       Impact factor: 2.649

7.  A potent prolyl hydroxylase inhibitor, P-1894B, produced by a strain of Streptomyces.

Authors:  H Okazaki; K Ohta; T Kanamaru; T Ishimaru; T Kishi
Journal:  J Antibiot (Tokyo)       Date:  1981-10       Impact factor: 2.649

8.  Total synthesis of vineomycin B2.

Authors:  Shunichi Kusumi; Satoshi Tomono; Shunsuke Okuzawa; Erika Kaneko; Takashi Ueda; Kaname Sasaki; Daisuke Takahashi; Kazunobu Toshima
Journal:  J Am Chem Soc       Date:  2013-10-11       Impact factor: 15.419

9.  Saquayamycins, new aquayamycin-group antibiotics.

Authors:  T Uchida; M Imoto; Y Watanabe; K Miura; T Dobashi; N Matsuda; T Sawa; H Naganawa; M Hamada; T Takeuchi
Journal:  J Antibiot (Tokyo)       Date:  1985-09       Impact factor: 2.649

10.  Identification of the grincamycin gene cluster unveils divergent roles for GcnQ in different hosts, tailoring the L-rhodinose moiety.

Authors:  Yun Zhang; Hongbo Huang; Qi Chen; Minghe Luo; Aijun Sun; Yongxiang Song; Junying Ma; Jianhua Ju
Journal:  Org Lett       Date:  2013-06-19       Impact factor: 6.005
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  5 in total

1.  Grincamycins P-T: Rearranged Angucyclines from the Marine Sediment-Derived Streptomyces sp. CNZ-748 Inhibit Cell Lines of the Rare Cancer Pseudomyxoma Peritonei.

Authors:  Zhuo Shang; Zachary E Ferris; Douglas Sweeney; Alexander B Chase; Chunhua Yuan; Yvonne Hui; Lukuan Hou; Ethan A Older; Dan Xue; Xiaoyu Tang; Weipeng Zhang; Prakash Nagarkatti; Mitzi Nagarkatti; Traci L Testerman; Paul R Jensen; Jie Li
Journal:  J Nat Prod       Date:  2021-04-26       Impact factor: 4.050

2.  Angucycline Glycosides from Mangrove-Derived Streptomycesdiastaticus subsp. SCSIO GJ056.

Authors:  Chun Gui; Yena Liu; Zhenbin Zhou; Shanwen Zhang; Yunfeng Hu; Yu-Cheng Gu; Hongbo Huang; Jianhua Ju
Journal:  Mar Drugs       Date:  2018-05-28       Impact factor: 5.118

3.  Cytotoxic, Anti-Migration, and Anti-Invasion Activities on Breast Cancer Cells of Angucycline Glycosides Isolated from a Marine-Derived Streptomyces sp.

Authors:  Xin-Ying Qu; Jin-Wei Ren; Ai-Hong Peng; Shi-Qi Lin; Dan-Dan Lu; Qian-Qian Du; Ling Liu; Xia Li; Er-Wei Li; Wei-Dong Xie
Journal:  Mar Drugs       Date:  2019-05-09       Impact factor: 5.118

4.  Integrated Metabolomic, Molecular Networking, and Genome Mining Analyses Uncover Novel Angucyclines From Streptomyces sp. RO-S4 Strain Isolated From Bejaia Bay, Algeria.

Authors:  Rima Ouchene; Didier Stien; Juliette Segret; Mouloud Kecha; Alice M S Rodrigues; Carole Veckerlé; Marcelino T Suzuki
Journal:  Front Microbiol       Date:  2022-06-23       Impact factor: 6.064

Review 5.  Marine Anthraquinones: Pharmacological and Toxicological Issues.

Authors:  Giulia Greco; Eleonora Turrini; Elena Catanzaro; Carmela Fimognari
Journal:  Mar Drugs       Date:  2021-05-13       Impact factor: 5.118
  5 in total

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