Literature DB >> 28218897

Mapping DNA methylation with high-throughput nanopore sequencing.

Arthur C Rand1, Miten Jain1, Jordan M Eizenga1, Audrey Musselman-Brown1, Hugh E Olsen1, Mark Akeson1, Benedict Paten1.   

Abstract

DNA chemical modifications regulate genomic function. We present a framework for mapping cytosine and adenosine methylation with the Oxford Nanopore Technologies MinION using this nanopore sequencer's ionic current signal. We map three cytosine variants and two adenine variants. The results show that our model is sensitive enough to detect changes in genomic DNA methylation levels as a function of growth phase in Escherichia coli.

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Year:  2017        PMID： 28218897      PMCID： PMC5704956          DOI： 10.1038/nmeth.4189

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  22 in total

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  122 in total

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