Literature DB >> 28213116

Pushing the limits of ultra-high resolution human brain imaging with SMS-EPI demonstrated for columnar level fMRI.

David A Feinberg1, An T Vu2, Alexander Beckett3.   

Abstract

Encoding higher spatial resolution in simultaneous multi-slice (SMS) EPI is highly dependent on gradient performance, high density receiver coil arrays and pulse sequence optimization. We simulate gradient amplitude and slew rate determination of EPI imaging performance in terms of minimum TE, echo spacing (ES) and spatial resolution. We discuss the effects of image zooming in pulse sequences that have been used for sub-millimeter resolutions and the trade-offs in using partial Fourier and parallel imaging to reduce TE, PSF and ES. Using optimizations for SMS EPI pulse sequences with available gradient and receiver hardware, experimental results in ultra-high resolution (UHR) (0.45-0.5mm isotropic) SMS-EPI fMRI and mapping ocular dominance columns (ODC) in human brain at 0.5 mm isotropic resolution are demonstrated. We discuss promising future directions of UHR fMRI.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28213116      PMCID： PMC5961953          DOI： 10.1016/j.neuroimage.2017.02.020

Source DB:  PubMed          Journal:  Neuroimage        ISSN： 1053-8119            Impact factor:   6.556


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