Atsushi Ishibe1, Mitsuyoshi Ota2, Shoichi Fujii2, Yusuke Suwa3,2,4, Shinsuke Suzuki3,2,4, Hirokazu Suwa3,2,4, Masashi Momiyama3, Jun Watanabe3, Kazuteru Watanabe3, Masataka Taguri4, Chikara Kunisaki2, Itaru Endo3. 1. Department of Gastroenterological Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan. a.ishibe1225@gmail.com. 2. Department of Surgery, Gastroenterological Center, Graduate School of Medicine, Yokohama City University, Yokohama, Japan. 3. Department of Gastroenterological Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan. 4. Department of Biostatistics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Abstract
BACKGROUND:Laparoscopic surgery has been widely accepted for the treatment of colorectal cancer; however, long-term outcomes in elderly patients remain controversial. The midterm results of a randomized trial comparing open surgery with laparoscopic surgery in elderly patients with colorectal cancer are presented. METHODS: This was a randomized trial comparing open surgery with laparoscopic surgery in elderly patients with colorectal cancer. The primary outcome was complication rate, and secondary outcomes included 3-year recurrence-free survival and overall survival. A total of 200 patients were randomly assigned to open surgery or laparoscopic surgery between 2008 and 2012. The main study objective was to compare the midterm outcomes of open surgery with those of laparoscopic surgery in elderly patients with colorectal cancer. This trial is registered with Clinical Trials.gov (NCT01862562). RESULTS: There were no differences between the laparoscopic surgery group and open surgery group in the 3-year overall survival rate (91.5% for laparoscopic surgery vs. 90.6% for open surgery, p = 0.638) or the 3-year recurrence-free survival rate (84.8% for laparoscopic surgery vs. 88.2% for open surgery, p = 0.324). The local recurrence rate was significantly higher in the laparoscopic surgery group than in the open surgery group in rectal cancer (13.8% for laparoscopic surgery vs. 0% for open surgery, p = 0.038). In subgroup analysis according to tumor location, there were no significant differences in the 3-year overall survival rate or 3-year recurrence-free survival rate between the two treatment groups. CONCLUSION: The midterm outcomes of laparoscopic surgery are similar to those of open surgery in elderly patients with colorectal cancer.
RCT Entities:
BACKGROUND: Laparoscopic surgery has been widely accepted for the treatment of colorectal cancer; however, long-term outcomes in elderly patients remain controversial. The midterm results of a randomized trial comparing open surgery with laparoscopic surgery in elderly patients with colorectal cancer are presented. METHODS: This was a randomized trial comparing open surgery with laparoscopic surgery in elderly patients with colorectal cancer. The primary outcome was complication rate, and secondary outcomes included 3-year recurrence-free survival and overall survival. A total of 200 patients were randomly assigned to open surgery or laparoscopic surgery between 2008 and 2012. The main study objective was to compare the midterm outcomes of open surgery with those of laparoscopic surgery in elderly patients with colorectal cancer. This trial is registered with Clinical Trials.gov (NCT01862562). RESULTS: There were no differences between the laparoscopic surgery group and open surgery group in the 3-year overall survival rate (91.5% for laparoscopic surgery vs. 90.6% for open surgery, p = 0.638) or the 3-year recurrence-free survival rate (84.8% for laparoscopic surgery vs. 88.2% for open surgery, p = 0.324). The local recurrence rate was significantly higher in the laparoscopic surgery group than in the open surgery group in rectal cancer (13.8% for laparoscopic surgery vs. 0% for open surgery, p = 0.038). In subgroup analysis according to tumor location, there were no significant differences in the 3-year overall survival rate or 3-year recurrence-free survival rate between the two treatment groups. CONCLUSION: The midterm outcomes of laparoscopic surgery are similar to those of open surgery in elderly patients with colorectal cancer.
Entities:
Keywords:
Colorectal cancer; Elderly patient; Laparoscopic surgery; Randomized study
Authors: Nicholas P West; Hirotoshi Kobayashi; Keiichi Takahashi; Aristoteles Perrakis; Klaus Weber; Werner Hohenberger; Kenichi Sugihara; Philip Quirke Journal: J Clin Oncol Date: 2012-04-02 Impact factor: 44.544
Authors: Francesc Vallribera Valls; Filippo Landi; Eloy Espín Basany; José Luis Sánchez García; Luis Miguel Jiménez Gómez; Marc Martí Gallostra; Luis Salgado Cruz; Manuel Armengol Carrasco Journal: Surg Endosc Date: 2014-06-14 Impact factor: 4.584
Authors: Pierre J Guillou; Philip Quirke; Helen Thorpe; Joanne Walker; David G Jayne; Adrian M H Smith; Richard M Heath; Julia M Brown Journal: Lancet Date: 2005 May 14-20 Impact factor: 79.321
Authors: Mark Buunen; Ruben Veldkamp; Wim C J Hop; Esther Kuhry; Johannes Jeekel; Eva Haglind; Lars Påhlman; Miguel A Cuesta; Simon Msika; Mario Morino; Antonio Lacy; Hendrik J Bonjer Journal: Lancet Oncol Date: 2008-12-13 Impact factor: 41.316
Authors: Heidi Nelson; Daniel J Sargent; H Sam Wieand; James Fleshman; Mehran Anvari; Steven J Stryker; Robert W Beart; Michael Hellinger; Richard Flanagan; Walter Peters; David Ota Journal: N Engl J Med Date: 2004-05-13 Impact factor: 91.245
Authors: David G Jayne; Pierre J Guillou; Helen Thorpe; Philip Quirke; Joanne Copeland; Adrian M H Smith; Richard M Heath; Julia M Brown Journal: J Clin Oncol Date: 2007-07-20 Impact factor: 44.544
Authors: Mariusz G Fleszar; Paulina Fortuna; Marek Zawadzki; Paweł Hodurek; Iwona Bednarz-Misa; Wojciech Witkiewicz; Małgorzata Krzystek-Korpacka Journal: J Clin Med Date: 2021-02-04 Impact factor: 4.241
Authors: Giuseppe Palomba; Vincenza Paola Dinuzzi; Marianna Capuano; Pietro Anoldo; Marco Milone; Giovanni Domenico De Palma; Giovanni Aprea Journal: J Robot Surg Date: 2021-11-07