| Literature DB >> 28198119 |
Kazuki Tsubokura1,2, Kenward K H Vong1, Ambara R Pradipta1, Akihiro Ogura1, Sayaka Urano1, Tsuyoshi Tahara3, Satoshi Nozaki3, Hirotaka Onoe3, Yoichi Nakao2, Regina Sibgatullina4, Almira Kurbangalieva4, Yasuyoshi Watanabe3, Katsunori Tanaka1,4,5.
Abstract
Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin-AuIII complex was designed and developed that enables organ-specific, localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5- and TAMRA-linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.Entities:
Keywords: amide bond formation; fluorescent labeling; glycoalbumin; gold catalysis
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Year: 2017 PMID： 28198119 DOI： 10.1002/anie.201610273
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336