Literature DB >> 28197536

Proteomics reveals a new DNA repair factor involved in DNA damage signaling.

Markus Räschle1.   

Abstract

Stalling of the DNA replication machinery activates the ATR checkpoint kinase, which coordinates the cellular responses to replication stress. New studies identify a novel ATR activator, ETAA1, which is indispensable for the maintenance of genome integrity. Dysregulation of ETAA1 may contribute to the development of pancreatic cancer.

Entities:  

Keywords:  ATR signaling; DNA Replication checkpoint; DNA repair; Proteomics

Year:  2016        PMID： 28197536      PMCID： PMC5287004          DOI： 10.1080/23723556.2016.1263713

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Mechanism of replication-coupled DNA interstrand crosslink repair.

Authors:  Markus Räschle; Puck Knipscheer; Puck Knipsheer; Milica Enoiu; Todor Angelov; Jingchuan Sun; Jack D Griffith; Tom E Ellenberger; Orlando D Schärer; Johannes C Walter
Journal:  Cell       Date:  2008-09-19       Impact factor: 41.582

Review 2.  ATR signalling: more than meeting at the fork.

Authors:  Edward A Nam; David Cortez
Journal:  Biochem J       Date:  2011-06-15       Impact factor: 3.857

3.  ETAA1 acts at stalled replication forks to maintain genome integrity.

Authors:  Thomas E Bass; Jessica W Luzwick; Gina Kavanaugh; Clinton Carroll; Huzefa Dungrawala; Gloria G Glick; Michael D Feldkamp; Reid Putney; Walter J Chazin; David Cortez
Journal:  Nat Cell Biol       Date:  2016-10-10       Impact factor: 28.824

4.  Activation of the ATR kinase by the RPA-binding protein ETAA1.

Authors:  Peter Haahr; Saskia Hoffmann; Maxim A X Tollenaere; Teresa Ho; Luis Ignacio Toledo; Matthias Mann; Simon Bekker-Jensen; Markus Räschle; Niels Mailand
Journal:  Nat Cell Biol       Date:  2016-10-10       Impact factor: 28.824

5.  A role for the MRN complex in ATR activation via TOPBP1 recruitment.

Authors:  Anja M Duursma; Robert Driscoll; Josh E Elias; Karlene A Cimprich
Journal:  Mol Cell       Date:  2013-04-11       Impact factor: 17.970

Review 6.  Causes and consequences of replication stress.

Authors:  Michelle K Zeman; Karlene A Cimprich
Journal:  Nat Cell Biol       Date:  2014-01       Impact factor: 28.824

7.  The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.

Authors:  Xin Xu; Sivaraja Vaithiyalingam; Gloria G Glick; Daniel A Mordes; Walter J Chazin; David Cortez
Journal:  Mol Cell Biol       Date:  2008-10-20       Impact factor: 4.272

8.  RPA inhibition increases replication stress and suppresses tumor growth.

Authors:  Jason G Glanzer; Shengqin Liu; Ling Wang; Adam Mosel; Aimin Peng; Greg G Oakley
Journal:  Cancer Res       Date:  2014-07-28       Impact factor: 12.701

9.  DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links.

Authors:  Markus Räschle; Godelieve Smeenk; Rebecca K Hansen; Tikira Temu; Yasuyoshi Oka; Marco Y Hein; Nagarjuna Nagaraj; David T Long; Johannes C Walter; Kay Hofmann; Zuzana Storchova; Jürgen Cox; Simon Bekker-Jensen; Niels Mailand; Matthias Mann
Journal:  Science       Date:  2015-04-30       Impact factor: 47.728

10.  Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.

Authors:  Erica J Childs; Evelina Mocci; Daniele Campa; Paige M Bracci; Steven Gallinger; Michael Goggins; Donghui Li; Rachel E Neale; Sara H Olson; Ghislaine Scelo; Laufey T Amundadottir; William R Bamlet; Maarten F Bijlsma; Amanda Blackford; Michael Borges; Paul Brennan; Hermann Brenner; H Bas Bueno-de-Mesquita; Federico Canzian; Gabriele Capurso; Giulia M Cavestro; Kari G Chaffee; Stephen J Chanock; Sean P Cleary; Michelle Cotterchio; Lenka Foretova; Charles Fuchs; Niccola Funel; Maria Gazouli; Manal Hassan; Joseph M Herman; Ivana Holcatova; Elizabeth A Holly; Robert N Hoover; Rayjean J Hung; Vladimir Janout; Timothy J Key; Juozas Kupcinskas; Robert C Kurtz; Stefano Landi; Lingeng Lu; Ewa Malecka-Panas; Andrea Mambrini; Beatrice Mohelnikova-Duchonova; John P Neoptolemos; Ann L Oberg; Irene Orlow; Claudio Pasquali; Raffaele Pezzilli; Cosmeri Rizzato; Amethyst Saldia; Aldo Scarpa; Rachael Z Stolzenberg-Solomon; Oliver Strobel; Francesca Tavano; Yogesh K Vashist; Pavel Vodicka; Brian M Wolpin; Herbert Yu; Gloria M Petersen; Harvey A Risch; Alison P Klein
Journal:  Nat Genet       Date:  2015-06-22       Impact factor: 38.330
  10 in total

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