Literature DB >> 28196973

Two new polyketides from the ascomycete fungus Leptosphaeria sp.

Jie Lin1, Renlei Wang1, Guohua Xu1, Zhengfeng Ding1, Xueshen Zhu1, Erwei Li2, Ling Liu2.   

Abstract

Leptosphaerins H and I (1 and 2), two new xanthone derivatives, and six known compounds, leptosphaerin F (3), monodictysin B (4), norlichexanthone (5), leptosphaerin D (6), moniliphenone (7) and emodinbianthrone (8) have been isolated from a scale-up fermentation of the ascomycete fungus Leptosphaeria sp. Their structures were primarily elucidated by interpretation of NMR spectroscopic data. The absolute configuration of 1 was assigned using the modified Mosher method, whereas that of C-8a in 2 was determined via the CD data. Compound 6 showed modest cytotoxicity against a panel of three human tumor cell lines.

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Year:  2017        PMID： 28196973     DOI： 10.1038/ja.2017.5

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  14 in total

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2.  Polyketides from the ascomycete fungus Leptosphaeria sp.

Authors:  Jie Lin; Shuchun Liu; Bingda Sun; Shubin Niu; Erwei Li; Xingzhong Liu; Yongsheng Che
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Authors:  K K Chexal; J S Holker; T J Simpson; K Young
Journal:  J Chem Soc Perkin 1       Date:  1975

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2.  Isolation and Bioactivity of Secondary Metabolites from Solid Culture of the Fungus, Alternaria sonchi.

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