| Literature DB >> 21158423 |
Cheng Ma1, Yan Li, Shubin Niu, Hua Zhang, Xingzhong Liu, Yongsheng Che.
Abstract
New N-hydroxypyridones, militarinones E (1) and F (2), phenylhydrazones, farylhydrazones A (3) and B (4), a quinazolinone, 2-(4-hydroxybenzyl)quinazolin-4(3H)-one (5), and the known militarinones A (6) and B (7) were isolated from cultures of the Cordyceps-colonizing fungus Isaria farinosa. The structures of 1-5 were elucidated by spectroscopic methods, and 3 was confirmed by X-ray crystallography. The absolute configuration of the C-4' secondary alcohol in 1 was deduced via the circular dichroism data of the in situ formed [Rh(2)(OCOCF(3))(4)] complex. Compounds 1 and 6 showed significant cytotoxicity against A549 cells, whereas 7 was active against Staphylococcus aureus, Streptococcus pneumoniae, and Candida albicans.Entities:
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Year: 2010 PMID： 21158423 DOI： 10.1021/np100568w
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050