Germaine M Buck Louis1, Melissa M Smarr2, Chirag J Patel3. 1. Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Room 3148, Rockville, MD, 20852, USA. louisg@mail.nih.gov. 2. Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Room 3148, Rockville, MD, 20852, USA. 3. Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck St., Boston, MA, 02115, USA.
Abstract
PURPOSE OF REVIEW: This paper presents an overview of the exposome research paradigm with particular application to understanding human reproduction and development and its implications for health across a lifespan. RECENT FINDINGS: The exposome research paradigm has generated considerable discussion about its feasibility and utility for delineating the impact of environmental exposures on human health. Early initiatives are underway, including smaller proof-of-principle studies and larger concerted efforts. Despite the notable challenges underlying the exposome paradigm, analytic techniques are being developed to handle its untargeted approach and correlated and multi-level or hierarchical data structures such initiatives generate, while considering multiple comparisons. The relatively short intervals for critical and sensitive windows of human reproduction and development seem well suited for exposome research and may revolutionize our understanding of later onset diseases. Early initiatives suggest that the exposome paradigm is feasible, but its utility remains to be established with applications to population human health research.
PURPOSE OF REVIEW: This paper presents an overview of the exposome research paradigm with particular application to understanding human reproduction and development and its implications for health across a lifespan. RECENT FINDINGS: The exposome research paradigm has generated considerable discussion about its feasibility and utility for delineating the impact of environmental exposures on human health. Early initiatives are underway, including smaller proof-of-principle studies and larger concerted efforts. Despite the notable challenges underlying the exposome paradigm, analytic techniques are being developed to handle its untargeted approach and correlated and multi-level or hierarchical data structures such initiatives generate, while considering multiple comparisons. The relatively short intervals for critical and sensitive windows of human reproduction and development seem well suited for exposome research and may revolutionize our understanding of later onset diseases. Early initiatives suggest that the exposome paradigm is feasible, but its utility remains to be established with applications to population human health research.
Authors: Arjun K Manrai; Yuxia Cui; Pierre R Bushel; Molly Hall; Spyros Karakitsios; Carolyn J Mattingly; Marylyn Ritchie; Charles Schmitt; Denis A Sarigiannis; Duncan C Thomas; David Wishart; David M Balshaw; Chirag J Patel Journal: Annu Rev Public Health Date: 2016-12-23 Impact factor: 21.981
Authors: Alexandra J Buck; John E Vena; Bridget M McGuinness; Maureen A Cooney; Germaine M Louis Journal: Environ Health Date: 2010-05-04 Impact factor: 5.984
Authors: Chirag J Patel; David H Rehkopf; John T Leppert; Walter M Bortz; Mark R Cullen; Glenn M Chertow; John Pa Ioannidis Journal: Int J Epidemiol Date: 2013-12-16 Impact factor: 7.196
Authors: Anne D Kershenbaum; Michael A Langston; Robert S Levine; Arnold M Saxton; Tonny J Oyana; Barbara J Kilbourne; Gary L Rogers; Lisaann S Gittner; Suzanne H Baktash; Patricia Matthews-Juarez; Paul D Juarez Journal: Int J Environ Res Public Health Date: 2014-11-28 Impact factor: 3.390
Authors: Shelley H Liu; Jennifer F Bobb; Birgit Claus Henn; Lourdes Schnaas; Martha M Tellez-Rojo; Chris Gennings; Manish Arora; Robert O Wright; Brent A Coull; Matt P Wand Journal: Environmetrics Date: 2018-05-18 Impact factor: 1.900
Authors: Susan Marie Viet; Jill C Falman; Lori S Merrill; Elaine M Faustman; David A Savitz; Nancy Mervish; Dana B Barr; Lisa A Peterson; Robert Wright; David Balshaw; Barbara O'Brien Journal: Int J Hyg Environ Health Date: 2021-05-23 Impact factor: 7.401