Literature DB >> 28193669

Overexpression of SmeDEF Efflux Pump Decreases Aminoglycoside Resistance in Stenotrophomonas maltophilia.

Yi-Wei Huang1, Cheng-Wen Lin2, Hsiao-Chen Ning3,4, Yi-Tsung Lin5,6, Yi-Chih Chang7, Tsuey-Ching Yang8.   

Abstract

The SmeDEF pump of Stenotrophomonas maltophilia is negatively regulated by SmeT. In this study, strains KJΔT (smeT deletion mutant) and KJT-Dm (mutant with a defective SmeT-binding site) showed increased resistance to chloramphenicol/nalidixic acid/macrolides and susceptibility to aminoglycoside. Overexpression of the SmeDEF pump, in either KJΔT or KJT-Dm, downregulated smeYZ expression, which is responsible for the reduced aminoglycoside resistance. Furthermore, the SmeRySy two-component regulatory system was downregulated in response to SmeDEF overexpression, which supports its involvement in the regulatory circuit.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  antibiotic resistance; bacteria; efflux pump; two-component regulatory system

Mesh：

Substances：

Year:  2017        PMID： 28193669      PMCID： PMC5404512          DOI： 10.1128/AAC.02685-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Contribution of resistance-nodulation-division efflux pump operon smeU1-V-W-U2-X to multidrug resistance of Stenotrophomonas maltophilia.

Authors:  Chao-Hsien Chen; Chiang-Ching Huang; Tsao-Chuen Chung; Rouh-Mei Hu; Yi-Wei Huang; Tsuey-Ching Yang
Journal:  Antimicrob Agents Chemother       Date:  2011-09-19       Impact factor: 5.191

Review 2.  Membrane protein structure: prediction versus reality.

Authors:  Arne Elofsson; Gunnar von Heijne
Journal:  Annu Rev Biochem       Date:  2007       Impact factor: 23.643

3.  SmeC, an outer membrane multidrug efflux protein of Stenotrophomonas maltophilia.

Authors:  Xian-Zhi Li; Li Zhang; Keith Poole
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

4.  SmeOP-TolCSm efflux pump contributes to the multidrug resistance of Stenotrophomonas maltophilia.

Authors:  Cheng-Wen Lin; Yi-Wei Huang; Rouh-Mei Hu; Tsuey-Ching Yang
Journal:  Antimicrob Agents Chemother       Date:  2014-01-06       Impact factor: 5.191

Review 5.  Stenotrophomonas maltophilia: an emerging global opportunistic pathogen.

Authors:  Joanna S Brooke
Journal:  Clin Microbiol Rev       Date:  2012-01       Impact factor: 26.132

6.  Inactivation of Lytic Transglycosylases Increases Susceptibility to Aminoglycosides and Macrolides by Altering the Outer Membrane Permeability of Stenotrophomonas maltophilia.

Authors:  Chao-Jung Wu; Yi-Wei Huang; Yi-Tsung Lin; Tsuey-Ching Yang
Journal:  Antimicrob Agents Chemother       Date:  2016-04-22       Impact factor: 5.191

7.  Characterization of the MexC-MexD-OprJ multidrug efflux system in DeltamexA-mexB-oprM mutants of Pseudomonas aeruginosa.

Authors:  N Gotoh; H Tsujimoto; M Tsuda; K Okamoto; A Nomura; T Wada; M Nakahashi; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  1998-08       Impact factor: 5.191

8.  A linkage between SmeIJK efflux pump, cell envelope integrity, and σE-mediated envelope stress response in Stenotrophomonas maltophilia.

Authors:  Yi-Wei Huang; Rung-Shiuan Liou; Yi-Tsung Lin; Hsin-Hui Huang; Tsuey-Ching Yang
Journal:  PLoS One       Date:  2014-11-12       Impact factor: 3.240

9.  Fine-Tuning of the Cpx Envelope Stress Response Is Required for Cell Wall Homeostasis in Escherichia coli.

Authors:  Antoine Delhaye; Jean-François Collet; Géraldine Laloux
Journal:  mBio       Date:  2016-02-23       Impact factor: 7.867

10.  Inactivation of SmeSyRy Two-Component Regulatory System Inversely Regulates the Expression of SmeYZ and SmeDEF Efflux Pumps in Stenotrophomonas maltophilia.

Authors:  Chao-Jung Wu; Yi-Wei Huang; Yi-Tsung Lin; Hsiao-Chen Ning; Tsuey-Ching Yang
Journal:  PLoS One       Date:  2016-08-11       Impact factor: 3.240
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  4 in total

1.  Novel Mechanisms of Efflux-Mediated Levofloxacin Resistance and Reduced Amikacin Susceptibility in Stenotrophomonas maltophilia.

Authors:  Punyawee Dulyayangkul; Karina Calvopiña; Kate J Heesom; Matthew B Avison
Journal:  Antimicrob Agents Chemother       Date:  2020-12-16       Impact factor: 5.191

2.  Roles of SmeYZ, SbiAB, and SmeDEF Efflux Systems in Iron Homeostasis of Stenotrophomonas maltophilia.

Authors:  Chao-Jung Wu; Yu Chen; Li-Hua Li; Cheng-Mu Wu; Yi-Tsung Lin; Cheng-Hua Ma; Tsuey-Ching Yang
Journal:  Microbiol Spectr       Date:  2022-06-01

3.  Mutations in Ribosomal Protein RplA or Treatment with Ribosomal Acting Antibiotics Activates Production of Aminoglycoside Efflux Pump SmeYZ in Stenotrophomonas maltophilia.

Authors:  Karina Calvopiña; Punyawee Dulyayangkul; Matthew B Avison
Journal:  Antimicrob Agents Chemother       Date:  2020-01-27       Impact factor: 5.191

4.  Advances in the Microbiology of Stenotrophomonas maltophilia.

Authors:  Joanna S Brooke
Journal:  Clin Microbiol Rev       Date:  2021-05-26       Impact factor: 50.129
  4 in total

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