Literature DB >> 28187357

A simple thick target for production of 89Zr using an 11MeV cyclotron.

Jeanne M Link1, Kenneth A Krohn2, Matthew J O'Hara3.   

Abstract

The growing interest but limited availability of 89Zr for PET led us to test targets for the 89Y(p,n) reaction. The goal was an easily constructed target for an 11MeV Siemens cyclotron. Yttrium foils were tested at different thicknesses, angles and currents. A 90° foil tolerated 41µA without damage and produced ~800 MBq/h, >20mCi, an amount adequate for radiochemistry research and human doses in a widely available accelerator. This method should translate to higher energy cyclotrons.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  (89)Zr production; 11MeV production; Experimental yields; RDS Eclipse; Target

Year:  2017        PMID： 28187357      PMCID： PMC5575845          DOI： 10.1016/j.apradiso.2017.01.037

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  8 in total

Review 1.  PET tracers based on Zirconium-89.

Authors:  Yin Zhang; Hao Hong; Weibo Cai
Journal:  Curr Radiopharm       Date:  2011-04

2.  Experimental studies on excitation functions of the proton-induced activation reactions on yttrium.

Authors:  M S Uddin; M Hagiwara; M Baba; F Tarkanyi; F Ditroi
Journal:  Appl Radiat Isot       Date:  2005-09       Impact factor: 1.513

3.  Zirconium-89 labeled panitumumab: a potential immuno-PET probe for HER1-expressing carcinomas.

Authors:  Sibaprasad Bhattacharyya; Karen Kurdziel; Ling Wei; Lisa Riffle; Gurmeet Kaur; G Craig Hill; Paula M Jacobs; James L Tatum; James H Doroshow; Joseph D Kalen
Journal:  Nucl Med Biol       Date:  2013-02-27       Impact factor: 2.408

4.  Performance of immuno-positron emission tomography with zirconium-89-labeled chimeric monoclonal antibody U36 in the detection of lymph node metastases in head and neck cancer patients.

Authors:  Pontus K E Börjesson; Yvonne W S Jauw; Ronald Boellaard; Remco de Bree; Emile F I Comans; Jan C Roos; Jonas A Castelijns; Maria J W D Vosjan; J Alain Kummer; C René Leemans; Adriaan A Lammertsma; Guus A M S van Dongen
Journal:  Clin Cancer Res       Date:  2006-04-01       Impact factor: 12.531

5.  Zirconium-labeled monoclonal antibodies and their distribution in tumor-bearing nude mice.

Authors:  W E Meijs; H J Haisma; R P Klok; F B van Gog; E Kievit; H M Pinedo; J D Herscheid
Journal:  J Nucl Med       Date:  1997-01       Impact factor: 10.057

6.  Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89.

Authors:  W E Meijs; J D Herscheid; H J Haisma; H M Pinedo
Journal:  Int J Rad Appl Instrum A       Date:  1992-12

7.  Standardized methods for the production of high specific-activity zirconium-89.

Authors:  Jason P Holland; Yiauchung Sheh; Jason S Lewis
Journal:  Nucl Med Biol       Date:  2009-07-29       Impact factor: 2.408

Review 8.  (89)Zr, a radiometal nuclide with high potential for molecular imaging with PET: chemistry, applications and remaining challenges.

Authors:  Gabriel Fischer; Uwe Seibold; Ralf Schirrmacher; Björn Wängler; Carmen Wängler
Journal:  Molecules       Date:  2013-06-03       Impact factor: 4.411
  8 in total

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