Literature DB >> 1334954

Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89.

W E Meijs1, J D Herscheid, H J Haisma, H M Pinedo.   

Abstract

Zirconium-desferal was prepared and analysed by TLC, NMR and u.v.-spectroscopy. The stoichiometry of the complex was found to be 1:1. Chelation of desferal, coupled to resin, with 88Zr appeared to be fast and almost quantitative in various buffer systems in a broad pH-range (4-7). A high in vitro stability of the zirconium-desferal complex was observed; less than 0.2% zirconium was lost within 24 h in plasma-solutions.

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Year:  1992        PMID: 1334954     DOI: 10.1016/0883-2889(92)90170-j

Source DB:  PubMed          Journal:  Int J Rad Appl Instrum A        ISSN: 0883-2889


  48 in total

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5.  The pharmacokinetics of Zr-89 labeled liposomes over extended periods in a murine tumor model.

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7.  Multifunctional Desferrichrome Analogues as Versatile 89Zr(IV) Chelators for ImmunoPET Probe Development.

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Review 8.  A physiological perspective on the use of imaging to assess the in vivo delivery of therapeutics.

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9.  Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab.

Authors:  Jason P Holland; Eloisi Caldas-Lopes; Vadim Divilov; Valerie A Longo; Tony Taldone; Danuta Zatorska; Gabriela Chiosis; Jason S Lewis
Journal:  PLoS One       Date:  2010-01-25       Impact factor: 3.240

10.  A simple thick target for production of 89Zr using an 11MeV cyclotron.

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Journal:  Appl Radiat Isot       Date:  2017-01-30       Impact factor: 1.513

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