| Literature DB >> 28154240 |
Yiwen Deng1, Keran Zhai1,2, Zhen Xie3, Dongyong Yang1,2, Xudong Zhu4, Junzhong Liu1, Xin Wang1, Peng Qin5, Yuanzhu Yang5, Guomin Zhang6, Qun Li1, Jianfu Zhang7, Shuangqing Wu8, Joëlle Milazzo9, Bizeng Mao3, Ertao Wang1, Huaan Xie7, Didier Tharreau9, Zuhua He10,3,11.
Abstract
Crop breeding aims to balance disease resistance with yield; however, single resistance (R) genes can lead to resistance breakdown, and R gene pyramiding may affect growth fitness. Here we report that the rice Pigm locus contains a cluster of genes encoding nucleotide-binding leucine-rich repeat (NLR) receptors that confer durable resistance to the fungus Magnaporthe oryzae without yield penalty. Among these NLR receptors, PigmR confers broad-spectrum resistance, whereas PigmS competitively attenuates PigmR homodimerization to suppress resistance. PigmS expression, and thus PigmR-mediated resistance, are subjected to tight epigenetic regulation. PigmS increases seed production to counteract the yield cost induced by PigmR Therefore, our study reveals a mechanism balancing high disease resistance and yield through epigenetic regulation of paired antagonistic NLR receptors, providing a tool to develop elite crop varieties.Entities:
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Year: 2017 PMID： 28154240 DOI： 10.1126/science.aai8898
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728