Literature DB >> 28149961

Histone demethylases and their roles in cancer epigenetics.

Alexandra D'Oto1, Qing-Wu Tian2, Andrew M Davidoff1, Jun Yang1.   

Abstract

The genetic abnormalities that drive tumorigenesis are usually coupled with epigenetic alterations, such as DNA methylation and aberrant histone modifications, which may help oncogenic drivers accelerate cancer progression, metastasis, and therapy resistance. The discovery of histone demethylases has provided us new insight for understanding the epigenetic landscape of the chromatin environment of cancer cells. This review aims to summarize the current knowledge on the human histone lysine demethylases and their functions in cancers, and recent advances in development of small molecule inhibitors to target histone demethylases in cancer treatment.

Entities:  

Keywords:  Cancer; Epigenetics; Histone demethylase

Year:  2016        PMID： 28149961      PMCID： PMC5279889     

Source DB:  PubMed          Journal:  J Med Oncol Ther


  81 in total

1.  Targeting Histone Demethylases: A New Avenue for the Fight against Cancer.

Authors:  Dante Rotili; Antonello Mai
Journal:  Genes Cancer       Date:  2011-06

2.  The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth.

Authors:  Jun Yang; Adrian M Jubb; Luke Pike; Francesca M Buffa; Helen Turley; Dilair Baban; Russell Leek; Kevin C Gatter; Jiannis Ragoussis; Adrian L Harris
Journal:  Cancer Res       Date:  2010-08-03       Impact factor: 12.701

3.  A feed-forward circuit controlling inducible NF-κB target gene activation by promoter histone demethylation.

Authors:  Dominic van Essen; Yina Zhu; Simona Saccani
Journal:  Mol Cell       Date:  2010-09-10       Impact factor: 17.970

4.  The histone demethylase UTX enables RB-dependent cell fate control.

Authors:  Jordon K Wang; Miao-Chih Tsai; Gino Poulin; Adam S Adler; Shuzhen Chen; Helen Liu; Yang Shi; Howard Y Chang
Journal:  Genes Dev       Date:  2010-02-01       Impact factor: 11.361

5.  A novel mammalian flavin-dependent histone demethylase.

Authors:  Aristotele Karytinos; Federico Forneris; Antonella Profumo; Giuseppe Ciossani; Elena Battaglioli; Claudia Binda; Andrea Mattevi
Journal:  J Biol Chem       Date:  2009-04-30       Impact factor: 5.157

6.  PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer.

Authors:  Jennifer M Spangle; Koen M Dreijerink; Anna C Groner; Hailing Cheng; Carolynn E Ohlson; Jaime Reyes; Charles Y Lin; James Bradner; Jean J Zhao; Thomas M Roberts; Myles Brown
Journal:  Cell Rep       Date:  2016-06-09       Impact factor: 9.423

Review 7.  Protein arginine methylation in mammals: who, what, and why.

Authors:  Mark T Bedford; Steven G Clarke
Journal:  Mol Cell       Date:  2009-01-16       Impact factor: 17.970

Review 8.  The Polycomb complex PRC2 and its mark in life.

Authors:  Raphaël Margueron; Danny Reinberg
Journal:  Nature       Date:  2011-01-20       Impact factor: 49.962

9.  A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

Authors:  Laurens Kruidenier; Chun-wa Chung; Zhongjun Cheng; John Liddle; KaHing Che; Gerard Joberty; Marcus Bantscheff; Chas Bountra; Angela Bridges; Hawa Diallo; Dirk Eberhard; Sue Hutchinson; Emma Jones; Roy Katso; Melanie Leveridge; Palwinder K Mander; Julie Mosley; Cesar Ramirez-Molina; Paul Rowland; Christopher J Schofield; Robert J Sheppard; Julia E Smith; Catherine Swales; Robert Tanner; Pamela Thomas; Anthony Tumber; Gerard Drewes; Udo Oppermann; Dinshaw J Patel; Kevin Lee; David M Wilson
Journal:  Nature       Date:  2012-08-16       Impact factor: 49.962

10.  Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.

Authors:  Gang G Wang; Jikui Song; Zhanxin Wang; Holger L Dormann; Fabio Casadio; Haitao Li; Jun-Li Luo; Dinshaw J Patel; C David Allis
Journal:  Nature       Date:  2009-06-11       Impact factor: 49.962
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  49 in total

Review 1.  The critical role of histone lysine demethylase KDM2B in cancer.

Authors:  Meina Yan; Xinxin Yang; Hui Wang; Qixiang Shao
Journal:  Am J Transl Res       Date:  2018-08-15       Impact factor: 4.060

2.  JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells.

Authors:  Lei Duan; Ricardo E Perez; Paul D Chastain; Mathew T Mathew; Divya Rani Bijukumar; Carl G Maki
Journal:  Oncogene       Date:  2019-04-09       Impact factor: 9.867

3.  Impact of Epigenetic Regulation on Head and Neck Squamous Cell Carcinoma.

Authors:  M V Bais
Journal:  J Dent Res       Date:  2019-01-07       Impact factor: 6.116

4.  KDM5B Promotes Drug Resistance by Regulating Melanoma-Propagating Cell Subpopulations.

Authors:  Xiaoni Liu; Shang-Min Zhang; Marcus W Bosenberg; Qin Yan; Meaghan K McGeary; Irina Krykbaeva; Ling Lai; Daniel J Jansen; Stephen C Kales; Anton Simeonov; Matthew D Hall; Daniel P Kelly
Journal:  Mol Cancer Ther       Date:  2018-12-06       Impact factor: 6.261

5.  Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment.

Authors:  Aditi Qamra; Tsz Wai Chu; Mélanie Criqui; Monika Sharma; Julissa Tsao; Danielle A Henry; Dalia Barsyte-Lovejoy; Cheryl H Arrowsmith; Neil Winegarden; Mathieu Lupien; Lea Harrington
Journal:  Elife       Date:  2020-04-16       Impact factor: 8.140

6.  Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia.

Authors:  Zheng Ge; Yan Gu; Qi Han; Justin Sloane; Qinyu Ge; Goufeng Gao; Jinlong Ma; Huihui Song; Jiaojiao Hu; Baoan Chen; Sinisa Dovat; Chunhua Song
Journal:  Epigenomics       Date:  2017-10-10       Impact factor: 4.778

Review 7.  On top of biosynthetic gene clusters: How epigenetic machinery influences secondary metabolism in fungi.

Authors:  Brandon T Pfannenstiel; Nancy P Keller
Journal:  Biotechnol Adv       Date:  2019-02-07       Impact factor: 14.227

8.  Global epigenetic alterations of mesenchymal stem cells in obesity: the role of vitamin C reprogramming.

Authors:  Mohsen Afarideh; Roman Thaler; Farzaneh Khani; Hui Tang; Kyra L Jordan; Sabena M Conley; Ishran M Saadiq; Yasin Obeidat; Aditya S Pawar; Alfonso Eirin; Xiang-Yang Zhu; Amir Lerman; Andre J van Wijnen; Lilach O Lerman
Journal:  Epigenetics       Date:  2020-09-20       Impact factor: 4.528

9.  KDM6A Lysine Demethylase Directs Epigenetic Polarity of MDSCs during Murine Sepsis.

Authors:  Isatou Bah; Tuqa Alkhateeb; Dima Youssef; Zhi Q Yao; Charles E McCall; Mohamed El Gazzar
Journal:  J Innate Immun       Date:  2021-07-21       Impact factor: 7.111

Review 10.  JMJD3: a critical epigenetic regulator in stem cell fate.

Authors:  Yuanjie Ding; Yuanchun Yao; Xingmu Gong; Qi Zhuo; Jinhua Chen; Miao Tian; Maryam Farzaneh
Journal:  Cell Commun Signal       Date:  2021-07-03       Impact factor: 5.712
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