Literature DB >> 30210666

The critical role of histone lysine demethylase KDM2B in cancer.

Meina Yan1, Xinxin Yang1, Hui Wang1, Qixiang Shao1.   

Abstract

The discovery of histone demethylases has revealed the dynamic nature of the regulation of histone methylation. KDM2B is an important histone lysine demethylase that removes methyl from H3K36me2 and H3K4me3. It participates in many aspects of normal cellular processes such as cell senescence, cell differentiation and stem cell self-renewal. Recent studies also showed that KDM2B was overexpressed in various types of cancers. This review focuses primarily on the current knowledge of KDM2B and its function in cancer development.

Entities:  

Keywords:  KDM2B; cancer; epigenetic regulation; histone demethylase

Year:  2018        PMID： 30210666      PMCID： PMC6129528     

Source DB:  PubMed          Journal:  Am J Transl Res            Impact factor:   4.060


  91 in total

1.  Synthetic Posttranslational Modifications: Chemical Catalyst-Driven Regioselective Histone Acylation of Native Chromatin.

Authors:  Yoshifumi Amamoto; Yuki Aoi; Nozomu Nagashima; Hiroki Suto; Daisuke Yoshidome; Yasuhiro Arimura; Akihisa Osakabe; Daiki Kato; Hitoshi Kurumizaka; Shigehiro A Kawashima; Kenzo Yamatsugu; Motomu Kanai
Journal:  J Am Chem Soc       Date:  2017-05-23       Impact factor: 15.419

2.  [Clinicopathologic features and expression of OCT4 protein in testicular diffuse large B cell lymphoma].

Authors:  Y P Chen; W F Zhu; L F Chen; J P Lu; T M He; W D Fu; C W Xu; G Chen
Journal:  Zhonghua Bing Li Xue Za Zhi       Date:  2017-06-08

3.  Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination.

Authors:  Wei Zhao; Qingtian Li; Stephen Ayers; Yifeng Gu; Zhong Shi; Qingyuan Zhu; Yidong Chen; Helen Y Wang; Rong-Fu Wang
Journal:  Cell       Date:  2013-02-28       Impact factor: 41.582

4.  Selective recruitment of breast cancer anti-estrogen resistance genes and relevance for breast cancer progression and tamoxifen therapy response.

Authors:  Ton van Agthoven; Anieta M Sieuwerts; Danielle Meijer; Marion E Meijer-van Gelder; Thecla L A van Agthoven; Roya Sarwari; Stefan Sleijfer; John A Foekens; Lambert C J Dorssers
Journal:  Endocr Relat Cancer       Date:  2010-02-18       Impact factor: 5.678

5.  Global levels of histone modifications predict prognosis in different cancers.

Authors:  David B Seligson; Steve Horvath; Matthew A McBrian; Vei Mah; Hong Yu; Sheila Tze; Qun Wang; David Chia; Lee Goodglick; Siavash K Kurdistani
Journal:  Am J Pathol       Date:  2009-04-06       Impact factor: 4.307

6.  Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis.

Authors:  Jaclyn Andricovich; Yan Kai; Weiqun Peng; Adlen Foudi; Alexandros Tzatsos
Journal:  J Clin Invest       Date:  2016-01-25       Impact factor: 14.808

7.  MiR-448 promotes glycolytic metabolism of gastric cancer by downregulating KDM2B.

Authors:  Xuehui Hong; Yang Xu; Xingfeng Qiu; Yuekun Zhu; Xing Feng; Zhijie Ding; Shifeng Zhang; Lifeng Zhong; Yifan Zhuang; Chen Su; Xinya Hong; Jianchun Cai
Journal:  Oncotarget       Date:  2016-04-19

8.  PD-L1 promotes OCT4 and Nanog expression in breast cancer stem cells by sustaining PI3K/AKT pathway activation.

Authors:  Sheema Almozyan; Dilek Colak; Fatmah Mansour; Ayodele Alaiya; Olfat Al-Harazi; Amal Qattan; Falah Al-Mohanna; Monther Al-Alwan; Hazem Ghebeh
Journal:  Int J Cancer       Date:  2017-06-30       Impact factor: 7.396

9.  A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

Authors:  Laurens Kruidenier; Chun-wa Chung; Zhongjun Cheng; John Liddle; KaHing Che; Gerard Joberty; Marcus Bantscheff; Chas Bountra; Angela Bridges; Hawa Diallo; Dirk Eberhard; Sue Hutchinson; Emma Jones; Roy Katso; Melanie Leveridge; Palwinder K Mander; Julie Mosley; Cesar Ramirez-Molina; Paul Rowland; Christopher J Schofield; Robert J Sheppard; Julia E Smith; Catherine Swales; Robert Tanner; Pamela Thomas; Anthony Tumber; Gerard Drewes; Udo Oppermann; Dinshaw J Patel; Kevin Lee; David M Wilson
Journal:  Nature       Date:  2012-08-16       Impact factor: 49.962

10.  Analyses of publicly available genomics resources define FGF-2-expressing bladder carcinomas as EMT-prone, proliferative tumors with low mutation rates and high expression of CTLA-4, PD-1 and PD-L1.

Authors:  Elizabeth A McNiel; Philip N Tsichlis
Journal:  Signal Transduct Target Ther       Date:  2017-03-17
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  22 in total

1.  Positional cloning and comprehensive mutation analysis identified a novel KDM2B mutation in a Japanese family with minor malformations, intellectual disability, and schizophrenia.

Authors:  Saeko Yokotsuka-Ishida; Masayuki Nakamura; Yoko Tomiyasu; Mio Nagai; Yuko Kato; Akiyuki Tomiyasu; Hiromi Umehara; Takehiro Hayashi; Natsuki Sasaki; Shu-Ichi Ueno; Akira Sano
Journal:  J Hum Genet       Date:  2021-01-06       Impact factor: 3.172

2.  Transcription factors linked to the molecular signatures in the development of hepatocellular carcinoma on a cirrhotic background.

Authors:  Jamshid Motalebzadeh; Elaheh Eskandari
Journal:  Med Oncol       Date:  2021-09-01       Impact factor: 3.064

Review 3.  Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications.

Authors:  Daniel Desaulniers; Paule Vasseur; Abigail Jacobs; M Cecilia Aguila; Norman Ertych; Miriam N Jacobs
Journal:  Int J Mol Sci       Date:  2021-10-11       Impact factor: 5.923

4.  Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate.

Authors:  Ryan J Weiss; Philipp N Spahn; Austin W T Chiang; Qing Liu; Jing Li; Kristina M Hamill; Sandra Rother; Thomas M Clausen; Marten A Hoeksema; Bryce M Timm; Kamil Godula; Christopher K Glass; Yitzhak Tor; Philip L S M Gordts; Nathan E Lewis; Jeffrey D Esko
Journal:  Nat Chem Biol       Date:  2021-04-12       Impact factor: 15.040

Review 5.  Jumonji C Demethylases in Cellular Senescence.

Authors:  Kelly E Leon; Katherine M Aird
Journal:  Genes (Basel)       Date:  2019-01-09       Impact factor: 4.096

6.  Tip60-dependent acetylation of KDM2B promotes osteosarcoma carcinogenesis.

Authors:  Xin Shi; Mingfu Fan
Journal:  J Cell Mol Med       Date:  2019-06-20       Impact factor: 5.310

7.  Transcriptional alterations in glioma result primarily from DNA methylation-independent mechanisms.

Authors:  Franck Court; Elisa Le Boiteux; Anne Fogli; Mélanie Müller-Barthélémy; Catherine Vaurs-Barrière; Emmanuel Chautard; Bruno Pereira; Julian Biau; Jean-Louis Kemeny; Toufic Khalil; Lucie Karayan-Tapon; Pierre Verrelle; Philippe Arnaud
Journal:  Genome Res       Date:  2019-09-18       Impact factor: 9.043

8.  Zinc and Its Transporters in Epigenetics.

Authors:  Sofia Brito; Mi-Gi Lee; Bum-Ho Bin; Jong-Soo Lee
Journal:  Mol Cells       Date:  2020-04-30       Impact factor: 5.034

9.  Oncogenic role of ALX3 in cervical cancer cells through KDM2B-mediated histone demethylation of CDC25A.

Authors:  Jinhong Qi; Li Zhou; Dongqing Li; Jingyuan Yang; He Wang; Huifang Cao; Yunlan Huang; Zhiming Zhang; Linlin Chang; Chenhao Zhu; Juntong Zhan; Yong Yuan
Journal:  BMC Cancer       Date:  2021-07-16       Impact factor: 4.430

10.  ELKS1 controls mast cell degranulation by regulating the transcription of Stxbp2 and Syntaxin 4 via Kdm2b stabilization.

Authors:  Hiu Yan Lam; Surendar Arumugam; Han Gyu Bae; Cheng Chun Wang; Sangyong Jung; Ashley Lauren St John; Wanjin Hong; Weiping Han; Vinay Tergaonkar
Journal:  Sci Adv       Date:  2020-07-31       Impact factor: 14.136
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