Literature DB >> 28138923

"It was an Emotional Baby": Previvors' Family Planning Decision-Making Styles about Hereditary Breast and Ovarian Cancer Risk.

Marleah Dean1, Emily A Rauscher2.   

Abstract

Women who test positive for a BRCA genetic mutation are at an increased risk for developing hereditary breast and ovarian cancer and have a 50% chance of passing on their genetic mutation to their children. The purpose of this study was to investigate how women who test positive for a BRCA mutation but have not been diagnosed with cancer make decisions regarding family planning. Analysis of interviews with 20 women revealed they engage in logical and emotional decision-making styles. Although women want to be logical to reduce their hereditary cancer risk, emotions often complicate their decision-making. Women experience fear and worry about a future cancer diagnosis, yet also desire to create a family, particularly having children through natural conception. That is, women negotiate having preventative surgeries in a logical doctor-recommended timeframe but also organize those decisions around emotional desires of motherhood. Overall, this study demonstrates the complex decisions women who test positive for a BRCA mutation must make in regards to genetic testing timing, family planning, and overall quality of life.

Entities:  

Keywords:  BRCA1, BRCA2; Decision-making; Disease risk; Family communication; Genetic risk; Genetic testing; Hereditary breast and ovarian cancer; Qualitative research

Mesh:

Year:  2017        PMID: 28138923     DOI: 10.1007/s10897-017-0069-8

Source DB:  PubMed          Journal:  J Genet Couns        ISSN: 1059-7700            Impact factor:   2.537


  54 in total

1.  Attitudes to reproductive genetic testing in women who had a positive BRCA test before having children: a qualitative analysis.

Authors:  Elizabeth Ormondroyd; Louise Donnelly; Clare Moynihan; Cornelie Savona; Elizabeth Bancroft; D Gareth Evans; Rosalind Eeles; Stuart Lavery; Maggie Watson
Journal:  Eur J Hum Genet       Date:  2011-08-03       Impact factor: 4.246

2.  BRCA carriers' thoughts on risk management in relation to preimplantation genetic diagnosis and childbearing: when too many choices are just as difficult as none.

Authors:  Gwendolyn P Quinn; Susan T Vadaparampil; Sharon Tollin; Cheryl A Miree; Devin Murphy; Bethanne Bower; Celso Silva
Journal:  Fertil Steril       Date:  2010-05-05       Impact factor: 7.329

3.  Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE.

Authors:  Nasim Mavaddat; Susan Peock; Debra Frost; Steve Ellis; Radka Platte; Elena Fineberg; D Gareth Evans; Louise Izatt; Rosalind A Eeles; Julian Adlard; Rosemarie Davidson; Diana Eccles; Trevor Cole; Jackie Cook; Carole Brewer; Marc Tischkowitz; Fiona Douglas; Shirley Hodgson; Lisa Walker; Mary E Porteous; Patrick J Morrison; Lucy E Side; M John Kennedy; Catherine Houghton; Alan Donaldson; Mark T Rogers; Huw Dorkins; Zosia Miedzybrodzka; Helen Gregory; Jacqueline Eason; Julian Barwell; Emma McCann; Alex Murray; Antonis C Antoniou; Douglas F Easton
Journal:  J Natl Cancer Inst       Date:  2013-04-29       Impact factor: 13.506

4.  Frozen hope: fertility preservation for women with cancer.

Authors:  Gwendolyn P Quinn; Susan T Vadaparampil; Paul B Jacobsen; Caprice Knapp; David L Keefe; Geri E Bell
Journal:  J Midwifery Womens Health       Date:  2010 Mar-Apr       Impact factor: 2.388

5.  Preserving the self: the process of decision making about hereditary breast cancer and ovarian cancer risk reduction.

Authors:  A Fuchsia Howard; Lynda G Balneaves; Joan L Bottorff; Patricia Rodney
Journal:  Qual Health Res       Date:  2010-10-27

6.  Experiences and decisions that motivate women at increased risk of breast cancer to participate in an experimental screening program.

Authors:  Michelle Proulx; Marie-Dominique Beaulieu; Christine Loignon; Marie-Hélène Mayrand; Christine Maugard; Nathalie Bellavance; Diane Provencher
Journal:  J Genet Couns       Date:  2009-02-14       Impact factor: 2.537

Review 7.  Clinical management of women at increased risk for breast cancer.

Authors:  V G Vogel; A Yeomans; E Higginbotham
Journal:  Breast Cancer Res Treat       Date:  1993-11       Impact factor: 4.872

8.  Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers.

Authors:  Kelly Metcalfe; Henry T Lynch; Parviz Ghadirian; Nadine Tung; Ivo Olivotto; Ellen Warner; Olufunmilayo I Olopade; Andrea Eisen; Barbara Weber; Jane McLennan; Ping Sun; William D Foulkes; Steven A Narod
Journal:  J Clin Oncol       Date:  2004-06-15       Impact factor: 44.544

9.  Danger zones: risk perceptions of young women from families with hereditary breast and ovarian cancer.

Authors:  Allison V Werner-Lin
Journal:  Fam Process       Date:  2007-09

10.  Anticipatory loss and early mastectomy for young female BRCA1/2 mutation carriers.

Authors:  Lindsey M Hoskins; Mark H Greene
Journal:  Qual Health Res       Date:  2012-08-27
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  5 in total

1.  Uptake of Preimplantation Genetic Diagnosis in Female BRCA1 and BRCA2 Mutation Carriers.

Authors:  Pnina Mor; Sarah Brennenstuhl; Kelly A Metcalfe
Journal:  J Genet Couns       Date:  2018-06-01       Impact factor: 2.537

2.  Perceptions and care Recommendations from Previvors: Qualitative analysis of female BRCA1/2 mutation Carriers' experience with genetic testing and counseling.

Authors:  Kate E Dibble; Laura K M Donorfio; Preston A Britner; Keith M Bellizzi
Journal:  Gynecol Oncol Rep       Date:  2022-05-02

3.  Attitudes and interest in incorporating BRCA1/2 cancer susceptibility testing into reproductive carrier screening for Ashkenazi Jewish men and women.

Authors:  Melanie W Hardy; Beth N Peshkin; Esther Rose; Mary Kathleen Ladd; Savannah Binion; Mara Tynan; Colleen M McBride; Karen A Grinzaid; Marc D Schwartz
Journal:  J Community Genet       Date:  2022-04-29

4.  Precision prophylaxis: Identifying the optimal timing for risk-reducing salpingo-oophorectomy based on type of BRCA1 and BRCA2 cluster region mutations.

Authors:  Ian Solsky; Jinbo Chen; Timothy R Rebbeck
Journal:  Gynecol Oncol       Date:  2020-01-07       Impact factor: 5.304

5.  Multi-Gene Mutation Profiling by Targeted Next-Generation Sequencing in Premenopausal Breast Cancer.

Authors:  Eleni Zografos; Angeliki Andrikopoulou; Alkistis Maria Papatheodoridi; Maria Kaparelou; Garyfalia Bletsa; Michalis Liontos; Meletios-Athanasios Dimopoulos; Flora Zagouri
Journal:  Genes (Basel)       Date:  2022-07-29       Impact factor: 4.141

  5 in total

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