PURPOSE: To suggest a novel classification of neovascular age-related macular degeneration (AMD) based on optical coherence tomography angiography (OCTA) and to correlate morphological characteristics based on optical coherence tomography (OCT)/OCTA with clinical criteria of disease activity. METHODS: A total of 88 eyes with neovascular AMD (14 treatment-naïve, 74 eyes following anti-vascular endothelial growth factor treatment (VEGF)) were examined using the AngioVue OCTA system (Optovue, Inc., Fremont, CA, USA) and evaluated based on vascular morphology. Choroidal neovascularization (CNV)-vessel morphology based on OCTA and associations with retinal layers were described and correlated with clinical markers of disease activity. RESULTS: In treatment-naïve CNV, CNV-vessel morphology based on OCTA showed a dense-net configuration (DN) in 12 of 14 eyes, a loose-net configuration (LN) in one of 14 eyes and an unidentifiable CNV pattern in one of 14 eyes, whereas in treated CNV, DN was registered in 43.2% (32/74), LN in 27% (20/74), DN with additional LN (mixed type) in 14.9% (11/74) and an unidentifiable CNV pattern in 14.9% (11/74). Clinical correlations revealed a significantly longer disease duration for LN with a median value of 4.3 years compared to DN with 2.0 years (p = 0.009) and for CNV involving the outer retina with 3.1 years compared to CNV not involving the outer retina with 1.9 years (p = 0.051). CONCLUSION: Optical coherence tomography angiography (OCTA) allows identification of distinct CNV-specific vascular patterns at the level of the outer retinal layer and choriocapillaris. Correlation with clinical and functional parameters may be useful to better understand pathophysiological mechanisms and guide efficient therapeutic strategies.
PURPOSE: To suggest a novel classification of neovascular age-related macular degeneration (AMD) based on optical coherence tomography angiography (OCTA) and to correlate morphological characteristics based on optical coherence tomography (OCT)/OCTA with clinical criteria of disease activity. METHODS: A total of 88 eyes with neovascular AMD (14 treatment-naïve, 74 eyes following anti-vascular endothelial growth factor treatment (VEGF)) were examined using the AngioVue OCTA system (Optovue, Inc., Fremont, CA, USA) and evaluated based on vascular morphology. Choroidal neovascularization (CNV)-vessel morphology based on OCTA and associations with retinal layers were described and correlated with clinical markers of disease activity. RESULTS: In treatment-naïve CNV, CNV-vessel morphology based on OCTA showed a dense-net configuration (DN) in 12 of 14 eyes, a loose-net configuration (LN) in one of 14 eyes and an unidentifiable CNV pattern in one of 14 eyes, whereas in treated CNV, DN was registered in 43.2% (32/74), LN in 27% (20/74), DN with additional LN (mixed type) in 14.9% (11/74) and an unidentifiable CNV pattern in 14.9% (11/74). Clinical correlations revealed a significantly longer disease duration for LN with a median value of 4.3 years compared to DN with 2.0 years (p = 0.009) and for CNV involving the outer retina with 3.1 years compared to CNV not involving the outer retina with 1.9 years (p = 0.051). CONCLUSION: Optical coherence tomography angiography (OCTA) allows identification of distinct CNV-specific vascular patterns at the level of the outer retinal layer and choriocapillaris. Correlation with clinical and functional parameters may be useful to better understand pathophysiological mechanisms and guide efficient therapeutic strategies.
Authors: Elham Ghahari; Christopher Bowd; Linda M Zangwill; Min Hee Suh; Takuhei Shoji; Kyle A Hasenstab; Luke J Saunders; Sasan Moghimi; Huiyuan Hou; Patricia I C Manalastas; Rafaella C Penteado; Robert N Weinreb Journal: J Glaucoma Date: 2018-04 Impact factor: 2.503
Authors: Elham Ghahari; Christopher Bowd; Linda M Zangwill; James Proudfoot; Kyle A Hasenstab; Huiyuan Hou; Rafaella C Penteado; Patricia Isabel C Manalastas; Sasan Moghimi; Takuhei Shoji; Mark Christopher; Adeleh Yarmohammadi; Robert N Weinreb Journal: Am J Ophthalmol Date: 2019-03-14 Impact factor: 5.258
Authors: Marcus Ang; Anna C S Tan; Chui Ming Gemmy Cheung; Pearse A Keane; Rosa Dolz-Marco; Chelvin C A Sng; Leopold Schmetterer Journal: Graefes Arch Clin Exp Ophthalmol Date: 2018-01-09 Impact factor: 3.117
Authors: Henrik Faatz; Marie-Louise Gunnemann; Kai Rothaus; Marius Book; Matthias Gutfleisch; Albrecht Lommatzsch; Daniel Pauleikhoff Journal: Ophthalmologe Date: 2021-02 Impact factor: 1.059
Authors: Henrik Faatz; Kai Rothaus; Martin Ziegler; Marius Book; Georg Spital; Britta Heimes-Bussmann; Daniel Pauleikhoff; Albrecht Lommatzsch Journal: Int Ophthalmol Date: 2022-01-13 Impact factor: 2.029
Authors: Ye Sun; Raffael Liegl; Yan Gong; Anima Bühler; Bertan Cakir; Steven S Meng; Samuel B Burnim; Chi-Hsiu Liu; Tristan Reuer; Peipei Zhang; Johanna M Walz; Franziska Ludwig; Clemens Lange; Hansjürgen Agostini; Daniel Böhringer; Günther Schlunck; Lois E H Smith; Andreas Stahl Journal: EBioMedicine Date: 2017-03-21 Impact factor: 8.143