| Literature DB >> 28120220 |
Geng Li1,2, Pan Pan2, Qiuyan He1, Xiujuan Kong1, Kailang Wu2, Wei Zhang1,2, Yuntao Liu3, Huiting Huang4, Jianbo Liu4, Zhongde Zhang3, Xiaoping Lai1, Xiaohong Liu1,4, Jianguo Wu5,6.
Abstract
The dengue virus (DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics of the 2014 dengue strains, the envelope (E) gene sequences from 17 viral strains isolated from 168 dengue patient serum samples were sequenced and a phylogenetic tree was reconstructed. All 17 strains were serotype I strains, including 8 genotype I and 9 genotype V strains. Additionally, 6 genotype I strains that were probably introduced to China from Thailand before 2009 were widely transmitted in the 2013 and 2014 epidemics, and they continued to circulate until 2015, with one affinis strain being found in Singapore. The other 2 genotype I strains were introduced from the Malaya Peninsula in 2014. The transmission source of the 9 genotype V strains was from Malaysia in 2014. DENVs of different serotypes and genotypes co-circulated in the 2014 dengue outbreak in Guangzhou. Moreover, not only had DENV been imported to Guangzhou, but it had also been gradually exported, as the viruses exhibited an enzootic transmission cycle in Guangzhou.Entities:
Keywords: dengue virus (DENV); envelope (E) gene; enzootic transmission cycle; phylogenetic analysis
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Year: 2017 PMID： 28120220 PMCID： PMC6702253 DOI： 10.1007/s12250-016-3872-8
Source DB: PubMed Journal: Virol Sin ISSN： 1995-820X Impact factor: 4.327